STAT2 signal transducer and activator of transcription 2 [Bos taurus (cattle)] - Gene

Summary

Official Symbol: STAT2provided by VGNC
Official Full Name: signal transducer and activator of transcription 2provided by VGNC
Primary source: VGNC:VGNC:35370
See related: BGD:BT11961; Ensembl:ENSBTAG00000004380
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	5	NC_037332.1 (56994869..57010632)

Chromosome 5 - NC_037332.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Prolonged treatment with IFN-alpha (12-48 h) resulted in increased expression of STAT1 and, to a lesser extent, STAT2.
Title: Interferon-alpha signalling in bovine adrenal chromaffin cells: involvement of signal-transducer and activator of transcription 1 and 2, extracellular signal-regulated protein kinases 1/2 and serine 31 phosphorylation of tyrosine hydroxylase.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info	PubMed
involved_in defense response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to peptide hormone	IEA Inferred from Electronic Annotation more info	PubMed
involved_in type I interferon-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: signal transducer and activator of transcription 2

Names: signal transducer and activator of transcription 2, 113kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001205689.1 → NP_001192618.1 signal transducer and activator of transcription 2

See identical proteins and their annotated locations for NP_001192618.1

Status: PROVISIONAL

Source sequence(s)

NKLS02000005

UniProtKB/TrEMBL

E1B8Z4

Conserved Domains (5) summary

cd10373
Location:556 → 706

SH2_STAT2; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 2 proteins

smart00964
Location:2 → 124

STAT_int; STAT protein, protein interaction domain

pfam01017
Location:142 → 314

STAT_alpha; STAT protein, all-alpha domain

pfam02864
Location:316 → 565

STAT_bind; STAT protein, DNA binding domain

pfam12188
Location:789 → 844

STAT2_C; Signal transducer and activator of transcription 2 C terminal

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

Range

56994869..57010632

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_059886296.1 → XP_059742279.1 signal transducer and activator of transcription 2 isoform X1

UniProtKB/TrEMBL

E1B8Z4

Related

ENSBTAP00000005749.5, ENSBTAT00000005749.6
XM_059886298.1 → XP_059742281.1 signal transducer and activator of transcription 2 isoform X2