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OAS2 2'-5'-oligoadenylate synthetase 2 [ Homo sapiens (human) ]

Gene ID: 4939, updated on 5-Mar-2024

Summary

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Official Symbol
OAS2provided by HGNC
Official Full Name
2'-5'-oligoadenylate synthetase 2provided by HGNC
Primary source
HGNC:HGNC:8087
See related
Ensembl:ENSG00000111335 MIM:603350; AllianceGenome:HGNC:8087
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Expression
Broad expression in spleen (RPKM 18.2), lymph node (RPKM 14.1) and 22 other tissues See more
Orthologs
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Genomic context

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Location:
12q24.13
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (112978519..113011723)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (112955143..112988347)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (113416324..113449528)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7052 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_24142 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_24146 and experimental_24152 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_24159 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_24163 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_24171 and experimental_24176 Neighboring gene 2'-5'-oligoadenylate synthetase 1 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_24215 and experimental_24231 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_24264 and experimental_24270 Neighboring gene Sharpr-MPRA regulatory region 3381 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_24293 and experimental_24295 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_24298, experimental_24301 and experimental_24306 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_24317/24320 and experimental_24338 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_24357 and experimental_24368 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_24404 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_24448 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_24456 and experimental_24461 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_24463 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_24487 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7053 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_24505 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_24515 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4887 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_24520 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_24535 Neighboring gene MPRA-validated peak1965 silencer Neighboring gene 2'-5'-oligoadenylate synthetase 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:113400746-113401246 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:113401247-113401747 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_24547 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_24553 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7054 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7056 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7055 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7057 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_24560 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_24566 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_24567 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:113444541-113445740 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_24568 Neighboring gene inner mitochondrial membrane peptidase subunit 1 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4888 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7058 Neighboring gene ribosomal protein S15a pseudogene 32

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Quantitative Proteomic Profile of Psoriatic Epidermis Identifies OAS2 as a Novel Biomarker for Disease Activity. Zhou Y, et al. Front Immunol, 2020. PMID 32849499, Free PMC Article
  2. Structural and Hydrodynamic Characterization of Dimeric Human Oligoadenylate Synthetase 2. Koul A, et al. Biophys J, 2020 Jun 2. PMID 32413313, Free PMC Article
  3. Impact of double-stranded RNA characteristics on the activation of human 2'-5'-oligoadenylate synthetase 2 (OAS2). Koul A, et al. Biochem Cell Biol, 2020 Feb. PMID 30965010
  4. Polymorphism of OAS2 rs739901 C/A Involves the Susceptibility to EV71 Infection in Chinese Children. Tan YX, et al. Curr Med Sci, 2018 Aug. PMID 30128873
  5. Epigenetic regulation of OAS2 shows disease-specific DNA methylation profiles at individual CpG sites. Gu X, et al. Sci Rep, 2016 Aug 30. PMID 27572959, Free PMC Article

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. OAS1, OAS2, and OAS3 Contribute to Epidermal Keratinocyte Proliferation by Regulating Cell Cycle and Augmenting IFN-1Induced Jak1Signal Transducer and Activator of Transcription 1 Phosphorylation in Psoriasis.
    Title: OAS1, OAS2, and OAS3 Contribute to Epidermal Keratinocyte Proliferation by Regulating Cell Cycle and Augmenting IFN-1‒Induced Jak1‒Signal Transducer and Activator of Transcription 1 Phosphorylation in Psoriasis.
  2. Long noncoding RNA SATB1-AS1 contributes to the chemotherapy resistance through the microRNA-580/ 2'-5'-oligoadenylate synthetase 2 axis in acute myeloid leukemia.
    Title: Long noncoding RNA SATB1-AS1 contributes to the chemotherapy resistance through the microRNA-580/ 2'-5'-oligoadenylate synthetase 2 axis in acute myeloid leukemia.
  3. Structural and Hydrodynamic Characterization of Dimeric Human Oligoadenylate Synthetase 2.
    Title: Structural and Hydrodynamic Characterization of Dimeric Human Oligoadenylate Synthetase 2.
  4. Quantitative Proteomic Profile of Psoriatic Epidermis Identifies OAS2 as a Novel Biomarker for Disease Activity.
    Title: Quantitative Proteomic Profile of Psoriatic Epidermis Identifies OAS2 as a Novel Biomarker for Disease Activity.
  5. The OAS2 showed a marked increase in activity with increasing dsRNA length with a minimum requirement of 35 bp.
    Title: Impact of double-stranded RNA characteristics on the activation of human 2'-5'-oligoadenylate synthetase 2 (OAS2).
  6. Low OAS2 expression is associated with colorectal cancer metastasis, mediating perineural and lymphovascular invasion.
    Title: Opposite functions of GSN and OAS2 on colorectal cancer metastasis, mediating perineural and lymphovascular invasion, respectively.
  7. OAS2 rs739901 5'-flanking C/A genetic polymorphisms involve the susceptibility to EV71 infection, and A allele might be a risk factor of the susceptibility to EV-71 infection.
    Title: Polymorphism of OAS2 rs739901 C/A Involves the Susceptibility to EV71 Infection in Chinese Children.
  8. Mx1 and OAS1-2 polymorphisms were associated with the severity of liver disease in HIV/HCV-coinfected patients, suggesting a significant role in the progression of hepatic fibrosis.
    Title: Mx1, OAS1 and OAS2 polymorphisms are associated with the severity of liver disease in HIV/HCV-coinfected patients: A cross-sectional study.
  9. Epigenetic regulation of OAS2 shows disease-specific DNA methylation profiles at individual CpG sites.
    Title: Epigenetic regulation of OAS2 shows disease-specific DNA methylation profiles at individual CpG sites.
  10. we characterized the functional consequences of the Neandertal haplotype in the transcriptional regulation of OAS genes at baseline and infected conditions. We found that cells from people with the Neandertal-like haplotype express lower levels of OAS3 upon infection, as well as distinct isoforms of OAS1 and OAS2
    Title: Adaptively introgressed Neandertal haplotype at the OAS locus functionally impacts innate immune responses in humans.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
EBI GWAS Catalog
Preliminary evidence of genetic determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 and the viral protein Tat modulate the expression of 2',5'-oligoadenylate synthetase 2, 69/71kDa (OAS2) in immature dendritic cells and monocyte-derived macrophages PubMed
tat HIV-1 Tat interacts with interferon-inducible enzymes 2-5A synthetase and dsRNA-dependent protein kinase to influence the rate of translation and protein synthesis in vitro PubMed
Vpr vpr HIV-1 Vpr upregulates the gene expression of OAS2 in human monocyte-derived dendritic cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC78578

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 2'-5'-oligoadenylate synthetase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 2'-5'-oligoadenylate synthetase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 2'-5'-oligoadenylate synthetase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ATP binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables double-stranded RNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to virus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in interleukin-27-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of viral genome replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleobase-containing compound metabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of interferon-beta production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of lactation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of ribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to virus TAS
Traceable Author Statement
more info
 PubMed 
involved_in type I interferon-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in intracellular membrane-bounded organelle TAS
Traceable Author Statement
more info
 PubMed 
located_in membrane HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
2'-5'-oligoadenylate synthase 2
Names
(2'-5')oligo(A) synthetase 2
2'-5'-oligoadenylate synthetase 2, 69/71kDa
2-5A synthase 2
p69 OAS / p71 OAS
NP_001027903.1
NP_002526.2
NP_058197.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029692.1 RefSeqGene

    Range
    5051..38255
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001032731.2 → NP_001027903.1  2'-5'-oligoadenylate synthase 2 isoform 3

    See identical proteins and their annotated locations for NP_001027903.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an additional segment in the 5' coding region, compared to variant 1, which leads to a premature stop codon. It encodes isoform 3, which has a shorter, distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC004551, BC069052, BE885222
    Consensus CDS
    CCDS44982.1
    UniProtKB/TrEMBL
    Q7Z6D0
    Related
    ENSP00000411763.2, ENST00000449768.2
    Conserved Domains (1) summary
    cd05400
    Location:31 → 150
    NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme

  2. NM_002535.3 → NP_002526.2  2'-5'-oligoadenylate synthase 2 isoform 2

    See identical proteins and their annotated locations for NP_002526.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an additional segment in the 3' coding region, compared to variant 1, which leads to a premature stop codon. It encodes isoform 2, also known as p69, which has a shorter, distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC004551, BC049215, BE885222, BQ213828
    Consensus CDS
    CCDS41839.1
    UniProtKB/TrEMBL
    A8KA41
    Related
    ENSP00000376362.3, ENST00000392583.7
    Conserved Domains (2) summary
    cd05400
    Location:362 → 545
    NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
    pfam10421
    Location:498 → 685
    OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

  3. NM_016817.3 → NP_058197.2  2'-5'-oligoadenylate synthase 2 isoform 1

    See identical proteins and their annotated locations for NP_058197.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1), which is also known as the p71 isoform.
    Source sequence(s)
    AC004551, BC049215, BE885222, BQ213828
    Consensus CDS
    CCDS31906.1
    UniProtKB/Swiss-Prot
    A8K9T1, P29728, Q6PJ33, Q86XX8
    UniProtKB/TrEMBL
    A8KA41
    Related
    ENSP00000342278.4, ENST00000342315.8
    Conserved Domains (2) summary
    cd05400
    Location:362 → 545
    NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
    pfam10421
    Location:496 → 683
    OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    112978519..113011723
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    112955143..112988347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P29728.3 GenPept UniProtKB/Swiss-Prot:P29728

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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