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cdc7 cell division cycle 7 homolog (S. cerevisiae) [ Danio rerio (zebrafish) ]

Gene ID: 492768, updated on 27-Mar-2024

Summary

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Official Symbol
cdc7provided by ZNC
Official Full Name
cell division cycle 7 homolog (S. cerevisiae)provided by ZNC
Primary source
ZFIN:ZDB-GENE-041114-113
See related
Ensembl:ENSDARG00000023584 AllianceGenome:ZFIN:ZDB-GENE-041114-113
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
im:7138214; zgc:101602
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in double-strand break repair via break-induced replication and peptidyl-serine phosphorylation. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm and nucleus. Orthologous to human CDC7 (cell division cycle 7). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (10863941..10877769, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (11080352..11094171, complement)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene growth factor independent 1A transcription repressor a Neighboring gene RNA polymerase II associated protein 2 Neighboring gene glomulin, FKBP associated protein a Neighboring gene transcription elongation factor A (SII) N-terminal and central domain containing 2 Neighboring gene CUB domain containing protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Iroquois Homeobox 1 Acts as a True Tumor Suppressor in Multiple Organs by Regulating Cell Cycle Progression. Jung IH, et al. Neoplasia, 2019 Oct. PMID 31450023, Free PMC Article
  2. Distinct requirements for Wntless in habenular development. Kuan YS, et al. Dev Biol, 2015 Oct 15. PMID 26116173, Free PMC Article
  3. Prpf31 is essential for the survival and differentiation of retinal progenitor cells by modulating alternative splicing. Li J, et al. Nucleic Acids Res, 2021 Feb 26. PMID 33476374, Free PMC Article
  4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cell division cycle 7-related protein kinase
NP_001007410.1
XP_005171217.1
XP_005171218.1
XP_005171219.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007409.1 → NP_001007410.1  cell division cycle 7-related protein kinase

    See identical proteins and their annotated locations for NP_001007410.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085380
    UniProtKB/TrEMBL
    Q5U3V5
    Related
    ENSDARP00000091380.3, ENSDART00000100607.6
    Conserved Domains (2) summary
    smart00220
    Location:46 → 332
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14019
    Location:45 → 341
    STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    10863941..10877769 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005171162.4 → XP_005171219.1  cell division cycle 7-related protein kinase isoform X3

    UniProtKB/TrEMBL
    A0A8M2BID8, B0UYH9
    Related
    ENSDARP00000118103.1, ENSDART00000138718.3
    Conserved Domains (2) summary
    smart00220
    Location:46 → 364
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14019
    Location:45 → 373
    STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase

  2. XM_005171161.4 → XP_005171218.1  cell division cycle 7-related protein kinase isoform X2

    UniProtKB/TrEMBL
    A0A8M2BIV6
    Conserved Domains (3) summary
    smart00220
    Location:46 → 390
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14019
    Location:45 → 399
    STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase
    cl21453
    Location:300 → 481
    PKc_like; Protein Kinases, catalytic domain

  3. XM_005171160.4 → XP_005171217.1  cell division cycle 7-related protein kinase isoform X1

    UniProtKB/TrEMBL
    A0A8M2BIF5, B0UYI0
    Related
    ENSDARP00000032739.5, ENSDART00000034246.6
    Conserved Domains (2) summary
    cd14019
    Location:45 → 431
    STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase
    cl21453
    Location:332 → 513
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version

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