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UROS uroporphyrinogen III synthase [ Canis lupus familiaris (dog) ]

Gene ID: 492116, updated on 5-Mar-2024

Summary

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Official Symbol
UROSprovided by VGNC
Official Full Name
uroporphyrinogen III synthaseprovided by VGNC
Primary source
VGNC:VGNC:48170
See related
Ensembl:ENSCAFG00845026709
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 28
Exon count:
14
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 28 NC_051832.1 (35509930..35540636, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 28 NC_006610.4 (35010678..35042131, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 28 NC_049249.1 (35315163..35346614, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 28 NC_049288.1 (35063739..35095183, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 28 NC_049769.1 (35055275..35086722, complement)

Chromosome 28 - NC_051832.1Genomic Context describing neighboring genes Neighboring gene erythroid differentiation regulatory factor 1 Neighboring gene uncharacterized LOC111092965 Neighboring gene matrix metallopeptidase 21 Neighboring gene BRCA2 and CDKN1A interacting protein Neighboring gene DEAH-box helicase 32 (putative) Neighboring gene uncharacterized LOC119866617

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables uroporphyrinogen-III synthase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in uroporphyrinogen III biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
uroporphyrinogen-III synthase
Names
uroporphyrinogen III synthase (congenital erythropoietic porphyria)
XP_005637895.1
XP_005637897.1
XP_022267444.1
XP_022267446.1
XP_022267447.1
XP_022267448.1
XP_022267449.1
XP_038296821.1
XP_038296822.1
XP_038296823.1
XP_038296824.1
XP_038296825.1
XP_038296826.1
XP_038296827.1
XP_038296828.1
XP_038371419.1
XP_038371420.1
XP_038371421.1
XP_038371422.1
XP_038371423.1
XP_038371424.1
XP_038371425.1
XP_038371426.1
XP_038435009.1
XP_038435010.1
XP_038435011.1
XP_038435012.1
XP_038435013.1
XP_038435014.1
XP_038435015.1
XP_038435016.1
XP_038499245.1
XP_038499246.1
XP_038499247.1
XP_038499248.1
XP_038499249.1
XP_038499250.1
XP_038499251.1
XP_038499252.1
XP_854192.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051832.1 Reference ROS_Cfam_1.0

    Range
    35509930..35540636 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038440893.1 → XP_038296821.1  uroporphyrinogen-III synthase isoform X1

    UniProtKB/TrEMBL
    A0A8I3PZ86, A0A8I3PZJ5
    Related
    ENSCAFP00845036956.1, ENSCAFT00845047091.1
    Conserved Domains (1) summary
    cd06578
    Location:3 → 249
    HemD; Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in ...

  2. XM_038440896.1 → XP_038296824.1  uroporphyrinogen-III synthase isoform X2

    UniProtKB/TrEMBL
    A0A8I3PZ86
    Conserved Domains (1) summary
    cd06578
    Location:22 → 221
    HemD; Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in ...

  3. XM_038440897.1 → XP_038296825.1  uroporphyrinogen-III synthase isoform X2

    UniProtKB/TrEMBL
    A0A8I3PZ86
    Conserved Domains (1) summary
    cd06578
    Location:22 → 221
    HemD; Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in ...

  4. XM_038440894.1 → XP_038296822.1  uroporphyrinogen-III synthase isoform X1

    UniProtKB/TrEMBL
    A0A8I3PZ86, A0A8I3PZJ5
    Conserved Domains (1) summary
    cd06578
    Location:3 → 249
    HemD; Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in ...

  5. XM_038440895.1 → XP_038296823.1  uroporphyrinogen-III synthase isoform X1

    UniProtKB/TrEMBL
    A0A8I3PZ86, A0A8I3PZJ5
    Conserved Domains (1) summary
    cd06578
    Location:3 → 249
    HemD; Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in ...

  6. XM_038440898.1 → XP_038296826.1  uroporphyrinogen-III synthase isoform X2

    UniProtKB/TrEMBL
    A0A8I3PZ86
    Conserved Domains (1) summary
    cd06578
    Location:22 → 221
    HemD; Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in ...

  7. XM_038440899.1 → XP_038296827.1  uroporphyrinogen-III synthase isoform X3

    UniProtKB/TrEMBL
    A0A8C0RUE0, A0A8P0TEH6
    Conserved Domains (1) summary
    cd06578
    Location:3 → 221
    HemD; Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in ...

  8. XM_038440900.1 → XP_038296828.1  uroporphyrinogen-III synthase isoform X4

    UniProtKB/TrEMBL
    A0A8C0RUE0, A0A8P0TEH6
    Conserved Domains (1) summary
    cd06578
    Location:3 → 220
    HemD; Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in ...

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049288.1 Alternate UMICH_Zoey_3.1

    Range
    35063739..35095183 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038515491.1 → XP_038371419.1  uroporphyrinogen-III synthase isoform X1

  2. XM_038515494.1 → XP_038371422.1  uroporphyrinogen-III synthase isoform X2

  3. XM_038515495.1 → XP_038371423.1  uroporphyrinogen-III synthase isoform X2

  4. XM_038515492.1 → XP_038371420.1  uroporphyrinogen-III synthase isoform X1

  5. XM_038515493.1 → XP_038371421.1  uroporphyrinogen-III synthase isoform X1

  6. XM_038515496.1 → XP_038371424.1  uroporphyrinogen-III synthase isoform X2

  7. XM_038515497.1 → XP_038371425.1  uroporphyrinogen-III synthase isoform X3

    Conserved Domains (1) summary
    cd06578
    Location:3 → 221
    HemD; Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in ...

  8. XM_038515498.1 → XP_038371426.1  uroporphyrinogen-III synthase isoform X4

    Conserved Domains (1) summary
    cd06578
    Location:3 → 220
    HemD; Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in ...

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049769.1 Alternate UNSW_CanFamBas_1.0

    Range
    35055275..35086722 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038643317.1 → XP_038499245.1  uroporphyrinogen-III synthase isoform X1

  2. XM_038643320.1 → XP_038499248.1  uroporphyrinogen-III synthase isoform X2

  3. XM_038643321.1 → XP_038499249.1  uroporphyrinogen-III synthase isoform X2

  4. XM_038643318.1 → XP_038499246.1  uroporphyrinogen-III synthase isoform X1

  5. XM_038643319.1 → XP_038499247.1  uroporphyrinogen-III synthase isoform X1

  6. XM_038643322.1 → XP_038499250.1  uroporphyrinogen-III synthase isoform X2

  7. XM_038643323.1 → XP_038499251.1  uroporphyrinogen-III synthase isoform X3

    Conserved Domains (1) summary
    cd06578
    Location:3 → 221
    HemD; Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in ...

  8. XM_038643324.1 → XP_038499252.1  uroporphyrinogen-III synthase isoform X4

    Conserved Domains (1) summary
    cd06578
    Location:3 → 220
    HemD; Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in ...

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049249.1 Alternate UU_Cfam_GSD_1.0

    Range
    35315163..35346614 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038579081.1 → XP_038435009.1  uroporphyrinogen-III synthase isoform X1

    UniProtKB/TrEMBL
    A0A8C0TFR4, A0A8I3PZ86, A0A8P0SHG6

  2. XM_038579084.1 → XP_038435012.1  uroporphyrinogen-III synthase isoform X2

    UniProtKB/TrEMBL
    A0A8I3PZ86

  3. XM_038579085.1 → XP_038435013.1  uroporphyrinogen-III synthase isoform X2

    UniProtKB/TrEMBL
    A0A8I3PZ86

  4. XM_038579082.1 → XP_038435010.1  uroporphyrinogen-III synthase isoform X1

    UniProtKB/TrEMBL
    A0A8C0TFR4, A0A8I3PZ86, A0A8P0SHG6

  5. XM_038579083.1 → XP_038435011.1  uroporphyrinogen-III synthase isoform X1

    UniProtKB/TrEMBL
    A0A8C0TFR4, A0A8I3PZ86, A0A8P0SHG6

  6. XM_038579086.1 → XP_038435014.1  uroporphyrinogen-III synthase isoform X2

    UniProtKB/TrEMBL
    A0A8I3PZ86

  7. XM_038579087.1 → XP_038435015.1  uroporphyrinogen-III synthase isoform X3

    UniProtKB/TrEMBL
    A0A8C0RUE0, A0A8P0TEH6
    Conserved Domains (1) summary
    cd06578
    Location:3 → 221
    HemD; Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in ...

  8. XM_038579088.1 → XP_038435016.1  uroporphyrinogen-III synthase isoform X4

    UniProtKB/TrEMBL
    A0A8C0RUE0, A0A8P0TEH6
    Conserved Domains (1) summary
    cd06578
    Location:3 → 220
    HemD; Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in ...

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006610.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    35010678..35042131 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_849099.6 → XP_854192.1  uroporphyrinogen-III synthase isoform X1

    See identical proteins and their annotated locations for XP_854192.1

    UniProtKB/TrEMBL
    A0A8C0TFR4, A0A8I3PZ86, A0A8P0SHG6
    Conserved Domains (1) summary
    cd06578
    Location:3 → 255
    HemD; Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in ...

  2. XM_005637840.4 → XP_005637897.1  uroporphyrinogen-III synthase isoform X2

    UniProtKB/TrEMBL
    A0A8I3PZ86
    Conserved Domains (1) summary
    cd06578
    Location:22 → 227
    HemD; Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in ...

  3. XM_022411738.2 → XP_022267446.1  uroporphyrinogen-III synthase isoform X2

    UniProtKB/TrEMBL
    A0A8I3PZ86
    Conserved Domains (1) summary
    cd06578
    Location:22 → 227
    HemD; Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in ...

  4. XM_022411736.2 → XP_022267444.1  uroporphyrinogen-III synthase isoform X1

    UniProtKB/TrEMBL
    A0A8C0TFR4, A0A8I3PZ86, A0A8P0SHG6
    Conserved Domains (1) summary
    cd06578
    Location:3 → 255
    HemD; Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in ...

  5. XM_005637838.4 → XP_005637895.1  uroporphyrinogen-III synthase isoform X1

    See identical proteins and their annotated locations for XP_005637895.1

    UniProtKB/TrEMBL
    A0A8C0TFR4, A0A8I3PZ86, A0A8P0SHG6
    Conserved Domains (1) summary
    cd06578
    Location:3 → 255
    HemD; Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in ...

  6. XM_022411739.2 → XP_022267447.1  uroporphyrinogen-III synthase isoform X2

    UniProtKB/TrEMBL
    A0A8I3PZ86
    Conserved Domains (1) summary
    cd06578
    Location:22 → 227
    HemD; Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in ...

  7. XM_022411740.2 → XP_022267448.1  uroporphyrinogen-III synthase isoform X3

    UniProtKB/TrEMBL
    A0A8C0RUE0, A0A8P0TEH6
    Conserved Domains (1) summary
    cd06578
    Location:3 → 221
    HemD; Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in ...

  8. XM_022411741.2 → XP_022267449.1  uroporphyrinogen-III synthase isoform X4

    UniProtKB/TrEMBL
    A0A8C0RUE0, A0A8P0TEH6
    Conserved Domains (1) summary
    cd06578
    Location:3 → 220
    HemD; Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in ...
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