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PDGFA platelet derived growth factor subunit A [ Canis lupus familiaris (dog) ]

Gene ID: 491597, updated on 5-Mar-2024

Summary

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Official Symbol
PDGFAprovided by VGNC
Official Full Name
platelet derived growth factor subunit Aprovided by VGNC
Primary source
VGNC:VGNC:44368
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 6
Exon count:
9
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 6 NC_051810.1 (16400056..16421423)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 6 NC_006588.4 (17743941..17762483)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 6 NC_049227.1 (16420378..16438910)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 6 NC_049266.1 (16204088..16222628)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 6 NC_049747.1 (16130433..16148998)

Chromosome 6 - NC_051810.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102154659 Neighboring gene protein kinase cAMP-dependent type I regulatory subunit beta Neighboring gene uncharacterized LOC102154711 Neighboring gene uncharacterized LOC119872327 Neighboring gene forkhead box L3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Platelet-derived growth factors and receptors in Canine Lymphoma. Aricò A, et al. J Comp Pathol, 2014 Nov. PMID 25172054

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables platelet-derived growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in platelet-derived growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
platelet-derived growth factor subunit A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190172.1 → NP_001177101.1  platelet-derived growth factor subunit A precursor

    See identical proteins and their annotated locations for NP_001177101.1

    Status: PROVISIONAL

    Source sequence(s)
    JAAUVH010000065
    UniProtKB/TrEMBL
    A0A8C0M6T8, Q5I4H7
    Conserved Domains (2) summary
    smart00141
    Location:94 → 181
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam04692
    Location:21 → 95
    PDGF_N; Platelet-derived growth factor, N terminal region

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051810.1 Reference ROS_Cfam_1.0

    Range
    16400056..16421423
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038667631.1 → XP_038523559.1  platelet-derived growth factor subunit A isoform X1

    Conserved Domains (2) summary
    smart00141
    Location:97 → 184
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam04692
    Location:24 → 98
    PDGF_N; Platelet-derived growth factor, N terminal region

  2. XM_038667633.1 → XP_038523561.1  platelet-derived growth factor subunit A isoform X2

    UniProtKB/TrEMBL
    A0A8C0S185
    Conserved Domains (2) summary
    smart00141
    Location:94 → 181
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam04692
    Location:21 → 95
    PDGF_N; Platelet-derived growth factor, N terminal region

  3. XM_038667632.1 → XP_038523560.1  platelet-derived growth factor subunit A isoform X2

    UniProtKB/TrEMBL
    A0A8C0S185
    Conserved Domains (2) summary
    smart00141
    Location:94 → 181
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam04692
    Location:21 → 95
    PDGF_N; Platelet-derived growth factor, N terminal region

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049266.1 Alternate UMICH_Zoey_3.1

    Range
    16204088..16222628
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049747.1 Alternate UNSW_CanFamBas_1.0

    Range
    16130433..16148998
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049227.1 Alternate UU_Cfam_GSD_1.0

    Range
    16420378..16438910
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006588.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    17743941..17762483
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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