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PLK1 polo like kinase 1 [ Canis lupus familiaris (dog) ]

Gene ID: 489971, updated on 5-Mar-2024

Summary

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Official Symbol
PLK1provided by VGNC
Official Full Name
polo like kinase 1provided by VGNC
Primary source
VGNC:VGNC:44695
See related
Ensembl:ENSCAFG00845001570
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 6
Exon count:
10
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 6 NC_051810.1 (22309120..22320926, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 6 NC_006588.4 (23732161..23743926, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 6 NC_049227.1 (22410301..22422125, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 6 NC_049266.1 (22112754..22124540, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 6 NC_049747.1 (22014857..22026662, complement)

Chromosome 6 - NC_051810.1Genomic Context describing neighboring genes Neighboring gene collagen alpha-1(I) chain-like Neighboring gene calcineurin like EF-hand protein 2 Neighboring gene endoplasmic reticulum to nucleus signaling 2 Neighboring gene uncharacterized LOC111096276 Neighboring gene dynactin subunit 5 Neighboring gene partner and localizer of BRCA2 Neighboring gene uncharacterized LOC111096275

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The mitotic regulator polo-like kinase 1 as a potential therapeutic target for c-Myc-overexpressing canine osteosarcomas. Gola C, et al. Vet Comp Oncol, 2022 Dec. PMID 36054794, Free PMC Article
  2. Polo-like kinase 1-mediated phosphorylation of the GTP-binding protein Ran is important for bipolar spindle formation. Feng Y, et al. Biochem Biophys Res Commun, 2006 Oct 13. PMID 16930555

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The mitotic regulator polo-like kinase 1 as a potential therapeutic target for c-Myc-overexpressing canine osteosarcomas.
    Title: The mitotic regulator polo-like kinase 1 as a potential therapeutic target for c-Myc-overexpressing canine osteosarcomas.
  2. Plk1 regulates the spindle organization partially through its phosphorylation on Ran
    Title: Polo-like kinase 1-mediated phosphorylation of the GTP-binding protein Ran is important for bipolar spindle formation.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cytokinesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein kinase PLK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase PLK1
XP_038334710.1
XP_038395957.1
XP_038460040.1
XP_038524758.1
XP_547091.3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051810.1 Reference ROS_Cfam_1.0

    Range
    22309120..22320926 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038668830.1 → XP_038524758.1  serine/threonine-protein kinase PLK1

    UniProtKB/TrEMBL
    A0A8C0L716, A0A8C0NVZ0, A0A8I3MIN2
    Related
    ENSCAFP00845002140.1, ENSCAFT00845002704.1
    Conserved Domains (3) summary
    cd13117
    Location:509 → 590
    POLO_box_2; Second polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
    cd13118
    Location:407 → 494
    POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
    cl21453
    Location:45 → 309
    PKc_like; Protein Kinases, catalytic domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049266.1 Alternate UMICH_Zoey_3.1

    Range
    22112754..22124540 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038478782.1 → XP_038334710.1  serine/threonine-protein kinase PLK1

    Conserved Domains (3) summary
    cd13117
    Location:509 → 590
    POLO_box_2; Second polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
    cd13118
    Location:407 → 494
    POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
    cl21453
    Location:45 → 309
    PKc_like; Protein Kinases, catalytic domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049747.1 Alternate UNSW_CanFamBas_1.0

    Range
    22014857..22026662 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038604112.1 → XP_038460040.1  serine/threonine-protein kinase PLK1

    Conserved Domains (3) summary
    cd13117
    Location:509 → 590
    POLO_box_2; Second polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
    cd13118
    Location:407 → 494
    POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
    cl21453
    Location:45 → 309
    PKc_like; Protein Kinases, catalytic domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049227.1 Alternate UU_Cfam_GSD_1.0

    Range
    22410301..22422125 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038540029.1 → XP_038395957.1  LOW QUALITY PROTEIN: serine/threonine-protein kinase PLK1

    UniProtKB/TrEMBL
    A0A8C0L716, A0A8C0NVZ0, A0A8I3MIN2
    Conserved Domains (3) summary
    cd13117
    Location:509 → 590
    POLO_box_2; Second polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
    cd13118
    Location:407 → 494
    POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
    cl21453
    Location:45 → 309
    PKc_like; Protein Kinases, catalytic domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006588.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    23732161..23743926 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_547091.7 → XP_547091.3  serine/threonine-protein kinase PLK1

    UniProtKB/TrEMBL
    A0A8C0L716, A0A8C0NVZ0, A0A8I3MIN2
    Conserved Domains (3) summary
    cd13117
    Location:509 → 590
    POLO_box_2; Second polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
    cd13118
    Location:407 → 494
    POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
    cl21453
    Location:45 → 309
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version

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