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PTPRU protein tyrosine phosphatase receptor type U [ Canis lupus familiaris (dog) ]

Gene ID: 487328, updated on 5-Mar-2024

Summary

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Official Symbol
PTPRUprovided by VGNC
Official Full Name
protein tyrosine phosphatase receptor type Uprovided by VGNC
Primary source
VGNC:VGNC:45200
See related
Ensembl:ENSCAFG00845007699
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
31
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 2 NC_051806.1 (71844918..71923499, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 2 NC_006584.4 (67861226..67939839, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 2 NC_049223.1 (70679504..70758203, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 2 NC_049262.1 (68673740..68752383, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 2 NC_049743.1 (69681824..69760389, complement)

Chromosome 2 - NC_051806.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC106557751 Neighboring gene uncharacterized LOC111093207 Neighboring gene U6 spliceosomal RNA Neighboring gene mitochondrial trans-2-enoyl-CoA reductase Neighboring gene serine and arginine rich splicing factor 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
receptor-type tyrosine-protein phosphatase U; LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase U
XP_005617742.1
XP_005617743.1
XP_005617744.1
XP_005617745.1
XP_038318054.1
XP_038326426.1
XP_038326427.1
XP_038326428.1
XP_038326429.1
XP_038326430.1
XP_038326431.1
XP_038387269.1
XP_038387270.1
XP_038387271.1
XP_038387272.1
XP_038387273.1
XP_038387274.1
XP_038451494.1
XP_038451495.1
XP_038451496.1
XP_038451497.1
XP_038451498.1
XP_038451499.1
XP_038515575.1
XP_852271.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051806.1 Reference ROS_Cfam_1.0

    Range
    71844918..71923499 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038659647.1 → XP_038515575.1  LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase U isoform X1

    UniProtKB/TrEMBL
    A0A8C0MHD2, A0A8I3MW46, A0A8P0NDN5
    Related
    ENSCAFP00845010571.1, ENSCAFT00845013617.1
    Conserved Domains (6) summary
    smart00137
    Location:22 → 186
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    COG2609
    Location:896 → 971
    AceE; Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion]
    cd00063
    Location:386 → 481
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14632
    Location:943 → 1147
    R-PTPc-U-1; catalytic domain of receptor-type tyrosine-protein phosphatase U, repeat 1
    cd14637
    Location:1232 → 1438
    R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
    pfam00041
    Location:494 → 577
    fn3; Fibronectin type III domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049262.1 Alternate UMICH_Zoey_3.1

    Range
    68673740..68752383 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038470499.1 → XP_038326427.1  receptor-type tyrosine-protein phosphatase U isoform X3

    Conserved Domains (6) summary
    smart00137
    Location:25 → 188
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    COG2609
    Location:898 → 973
    AceE; Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion]
    cd00063
    Location:388 → 483
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14632
    Location:945 → 1149
    R-PTPc-U-1; catalytic domain of receptor-type tyrosine-protein phosphatase U, repeat 1
    cd14637
    Location:1234 → 1440
    R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
    pfam00041
    Location:496 → 579
    fn3; Fibronectin type III domain

  2. XM_038470502.1 → XP_038326430.1  receptor-type tyrosine-protein phosphatase U isoform X5

  3. XM_038470498.1 → XP_038326426.1  receptor-type tyrosine-protein phosphatase U isoform X2

  4. XM_038470501.1 → XP_038326429.1  receptor-type tyrosine-protein phosphatase U isoform X4

  5. XM_038470500.1 → XP_038326428.1  receptor-type tyrosine-protein phosphatase U isoform X1

    Conserved Domains (6) summary
    smart00137
    Location:22 → 186
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    COG2609
    Location:896 → 971
    AceE; Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion]
    cd00063
    Location:386 → 481
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14632
    Location:943 → 1147
    R-PTPc-U-1; catalytic domain of receptor-type tyrosine-protein phosphatase U, repeat 1
    cd14637
    Location:1232 → 1438
    R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
    pfam00041
    Location:494 → 577
    fn3; Fibronectin type III domain

  6. XM_038470503.1 → XP_038326431.1  receptor-type tyrosine-protein phosphatase U isoform X6

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049743.1 Alternate UNSW_CanFamBas_1.0

    Range
    69681824..69760389 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038595567.1 → XP_038451495.1  receptor-type tyrosine-protein phosphatase U isoform X8

  2. XM_038595570.1 → XP_038451498.1  receptor-type tyrosine-protein phosphatase U isoform X10

  3. XM_038595566.1 → XP_038451494.1  receptor-type tyrosine-protein phosphatase U isoform X7

  4. XM_038595569.1 → XP_038451497.1  receptor-type tyrosine-protein phosphatase U isoform X9

  5. XM_038595568.1 → XP_038451496.1  receptor-type tyrosine-protein phosphatase U isoform X1

  6. XM_038595571.1 → XP_038451499.1  receptor-type tyrosine-protein phosphatase U isoform X11

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049223.1 Alternate UU_Cfam_GSD_1.0

    Range
    70679504..70758203 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038531342.1 → XP_038387270.1  receptor-type tyrosine-protein phosphatase U isoform X13

    UniProtKB/TrEMBL
    A0A8C0PPK9
    Conserved Domains (6) summary
    smart00137
    Location:25 → 188
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    COG2609
    Location:898 → 973
    AceE; Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion]
    cd00063
    Location:388 → 483
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14632
    Location:945 → 1149
    R-PTPc-U-1; catalytic domain of receptor-type tyrosine-protein phosphatase U, repeat 1
    cd14637
    Location:1234 → 1440
    R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
    pfam00041
    Location:496 → 579
    fn3; Fibronectin type III domain

  2. XM_038531345.1 → XP_038387273.1  receptor-type tyrosine-protein phosphatase U isoform X15

    UniProtKB/TrEMBL
    A0A8C0MQP6

  3. XM_038531341.1 → XP_038387269.1  receptor-type tyrosine-protein phosphatase U isoform X12

    UniProtKB/TrEMBL
    A0A8C0MDH9, A0A8P0PF37

  4. XM_038531344.1 → XP_038387272.1  receptor-type tyrosine-protein phosphatase U isoform X14

    UniProtKB/TrEMBL
    A0A8C0MQP6, A0A8I3N6Z2, A0A8P0NSE2

  5. XM_038531343.1 → XP_038387271.1  receptor-type tyrosine-protein phosphatase U isoform X1

    UniProtKB/TrEMBL
    A0A8C0MHD2, A0A8I3MW46, A0A8P0NDN5
    Conserved Domains (6) summary
    smart00137
    Location:22 → 186
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    COG2609
    Location:896 → 971
    AceE; Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion]
    cd00063
    Location:386 → 481
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14632
    Location:943 → 1147
    R-PTPc-U-1; catalytic domain of receptor-type tyrosine-protein phosphatase U, repeat 1
    cd14637
    Location:1232 → 1438
    R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
    pfam00041
    Location:494 → 577
    fn3; Fibronectin type III domain

  6. XM_038531346.1 → XP_038387274.1  receptor-type tyrosine-protein phosphatase U isoform X16

    UniProtKB/TrEMBL
    A0A8C0MDH9

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006584.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    67861226..67939839 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038462126.1 → XP_038318054.1  receptor-type tyrosine-protein phosphatase U isoform X18

    UniProtKB/TrEMBL
    A0A8C0PPK9
    Conserved Domains (6) summary
    smart00137
    Location:25 → 188
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    COG2609
    Location:898 → 973
    AceE; Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion]
    cd00063
    Location:388 → 483
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14632
    Location:945 → 1149
    R-PTPc-U-1; catalytic domain of receptor-type tyrosine-protein phosphatase U, repeat 1
    cd14637
    Location:1234 → 1440
    R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
    pfam00041
    Location:496 → 579
    fn3; Fibronectin type III domain

  2. XM_005617687.4 → XP_005617744.1  receptor-type tyrosine-protein phosphatase U isoform X20

    UniProtKB/TrEMBL
    A0A8C0MQP6
    Conserved Domains (5) summary
    smart00137
    Location:22 → 186
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    cd00047
    Location:1195 → 1428
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:386 → 481
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:494 → 577
    fn3; Fibronectin type III domain
    pfam00102
    Location:913 → 1133
    Y_phosphatase; Protein-tyrosine phosphatase

  3. XM_005617685.4 → XP_005617742.1  receptor-type tyrosine-protein phosphatase U isoform X17

    UniProtKB/TrEMBL
    A0A8C0MDH9, A0A8P0PF37
    Conserved Domains (5) summary
    smart00137
    Location:22 → 186
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    cd00047
    Location:1211 → 1444
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:386 → 481
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:494 → 577
    fn3; Fibronectin type III domain
    pfam00102
    Location:923 → 1149
    Y_phosphatase; Protein-tyrosine phosphatase

  4. XM_005617686.4 → XP_005617743.1  receptor-type tyrosine-protein phosphatase U isoform X19

    UniProtKB/TrEMBL
    A0A8C0MQP6, A0A8I3N6Z2, A0A8P0NSE2
    Conserved Domains (5) summary
    smart00137
    Location:22 → 186
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    cd00047
    Location:1201 → 1434
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:386 → 481
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:494 → 577
    fn3; Fibronectin type III domain
    pfam00102
    Location:913 → 1139
    Y_phosphatase; Protein-tyrosine phosphatase

  5. XM_847178.5 → XP_852271.1  receptor-type tyrosine-protein phosphatase U isoform X1

    UniProtKB/TrEMBL
    A0A8C0MHD2, A0A8I3MW46, A0A8P0NDN5
    Conserved Domains (6) summary
    smart00137
    Location:22 → 186
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    COG2609
    Location:896 → 971
    AceE; Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion]
    cd00063
    Location:386 → 481
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14632
    Location:943 → 1147
    R-PTPc-U-1; catalytic domain of receptor-type tyrosine-protein phosphatase U, repeat 1
    cd14637
    Location:1232 → 1438
    R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
    pfam00041
    Location:494 → 577
    fn3; Fibronectin type III domain

  6. XM_005617688.4 → XP_005617745.1  receptor-type tyrosine-protein phosphatase U isoform X21

    UniProtKB/TrEMBL
    A0A8C0MDH9
    Conserved Domains (5) summary
    smart00137
    Location:1 → 114
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    cd00047
    Location:1139 → 1372
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:314 → 409
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:422 → 505
    fn3; Fibronectin type III domain
    pfam00102
    Location:851 → 1077
    Y_phosphatase; Protein-tyrosine phosphatase
Nucleotide Protein
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