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CAPN5 calpain 5 [ Canis lupus familiaris (dog) ]

Gene ID: 485175, updated on 5-Mar-2024

Summary

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Official Symbol
CAPN5provided by VGNC
Official Full Name
calpain 5provided by VGNC
Primary source
VGNC:VGNC:38705
See related
Ensembl:ENSCAFG00845010073
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 21
Exon count:
15
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 21 NC_051825.1 (21825703..21878142, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 21 NC_006603.4 (21453573..21506018, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 21 NC_049242.1 (21741079..21793561, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 21 NC_049281.1 (21601212..21653579, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 21 NC_049762.1 (21817385..21869821, complement)

Chromosome 21 - NC_051825.1Genomic Context describing neighboring genes Neighboring gene nucleophosmin-like Neighboring gene glycerophosphodiester phosphodiesterase domain containing 4 Neighboring gene myosin VIIA Neighboring gene uncharacterized LOC119864973 Neighboring gene olfactory marker protein Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 Neighboring gene alkaline ceramidase 3 Neighboring gene T-complex protein 1 subunit eta-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium-dependent cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
calpain-5

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051825.1 Reference ROS_Cfam_1.0

    Range
    21825703..21878142 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038430006.1 → XP_038285934.1  calpain-5 isoform X1

    UniProtKB/TrEMBL
    A0A8I3NET5
    Conserved Domains (3) summary
    cd04046
    Location:526 → 638
    C2_Calpain; C2 domain present in Calpain proteins
    cd00214
    Location:352 → 498
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    pfam00648
    Location:27 → 341
    Peptidase_C2; Calpain family cysteine protease

  2. XM_038430005.1 → XP_038285933.1  calpain-5 isoform X1

    UniProtKB/TrEMBL
    A0A8I3NET5
    Related
    ENSCAFP00845013799.1, ENSCAFT00845017719.1
    Conserved Domains (3) summary
    cd04046
    Location:526 → 638
    C2_Calpain; C2 domain present in Calpain proteins
    cd00214
    Location:352 → 498
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    pfam00648
    Location:27 → 341
    Peptidase_C2; Calpain family cysteine protease

  3. XM_038430009.1 → XP_038285937.1  calpain-5 isoform X2

    Conserved Domains (3) summary
    cd04046
    Location:421 → 533
    C2_Calpain; C2 domain present in Calpain proteins
    cd00214
    Location:247 → 393
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    cl00051
    Location:64 → 236
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.

  4. XM_038430008.1 → XP_038285936.1  calpain-5 isoform X1

    UniProtKB/TrEMBL
    A0A8I3NET5
    Conserved Domains (3) summary
    cd04046
    Location:526 → 638
    C2_Calpain; C2 domain present in Calpain proteins
    cd00214
    Location:352 → 498
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    pfam00648
    Location:27 → 341
    Peptidase_C2; Calpain family cysteine protease

  5. XM_038430007.1 → XP_038285935.1  calpain-5 isoform X1

    UniProtKB/TrEMBL
    A0A8I3NET5
    Conserved Domains (3) summary
    cd04046
    Location:526 → 638
    C2_Calpain; C2 domain present in Calpain proteins
    cd00214
    Location:352 → 498
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    pfam00648
    Location:27 → 341
    Peptidase_C2; Calpain family cysteine protease

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049281.1 Alternate UMICH_Zoey_3.1

    Range
    21601212..21653579 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038505382.1 → XP_038361310.1  calpain-5 isoform X1

    Conserved Domains (3) summary
    cd04046
    Location:526 → 638
    C2_Calpain; C2 domain present in Calpain proteins
    cd00214
    Location:352 → 498
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    pfam00648
    Location:27 → 341
    Peptidase_C2; Calpain family cysteine protease

  2. XM_038505385.1 → XP_038361313.1  calpain-5 isoform X1

    Conserved Domains (3) summary
    cd04046
    Location:526 → 638
    C2_Calpain; C2 domain present in Calpain proteins
    cd00214
    Location:352 → 498
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    pfam00648
    Location:27 → 341
    Peptidase_C2; Calpain family cysteine protease

  3. XM_038505381.1 → XP_038361309.1  calpain-5 isoform X1

    Conserved Domains (3) summary
    cd04046
    Location:526 → 638
    C2_Calpain; C2 domain present in Calpain proteins
    cd00214
    Location:352 → 498
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    pfam00648
    Location:27 → 341
    Peptidase_C2; Calpain family cysteine protease

  4. XM_038505386.1 → XP_038361314.1  calpain-5 isoform X2

  5. XM_038505384.1 → XP_038361312.1  calpain-5 isoform X1

    Conserved Domains (3) summary
    cd04046
    Location:526 → 638
    C2_Calpain; C2 domain present in Calpain proteins
    cd00214
    Location:352 → 498
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    pfam00648
    Location:27 → 341
    Peptidase_C2; Calpain family cysteine protease

  6. XM_038505383.1 → XP_038361311.1  calpain-5 isoform X1

    Conserved Domains (3) summary
    cd04046
    Location:526 → 638
    C2_Calpain; C2 domain present in Calpain proteins
    cd00214
    Location:352 → 498
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    pfam00648
    Location:27 → 341
    Peptidase_C2; Calpain family cysteine protease

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049762.1 Alternate UNSW_CanFamBas_1.0

    Range
    21817385..21869821 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038632696.1 → XP_038488624.1  calpain-5 isoform X1

    Conserved Domains (3) summary
    cd04046
    Location:526 → 638
    C2_Calpain; C2 domain present in Calpain proteins
    cd00214
    Location:352 → 498
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    pfam00648
    Location:27 → 341
    Peptidase_C2; Calpain family cysteine protease

  2. XM_038632699.1 → XP_038488627.1  calpain-5 isoform X1

    Conserved Domains (3) summary
    cd04046
    Location:526 → 638
    C2_Calpain; C2 domain present in Calpain proteins
    cd00214
    Location:352 → 498
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    pfam00648
    Location:27 → 341
    Peptidase_C2; Calpain family cysteine protease

  3. XM_038632695.1 → XP_038488623.1  calpain-5 isoform X1

    Conserved Domains (3) summary
    cd04046
    Location:526 → 638
    C2_Calpain; C2 domain present in Calpain proteins
    cd00214
    Location:352 → 498
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    pfam00648
    Location:27 → 341
    Peptidase_C2; Calpain family cysteine protease

  4. XM_038632700.1 → XP_038488628.1  calpain-5 isoform X2

  5. XM_038632698.1 → XP_038488626.1  calpain-5 isoform X1

    Conserved Domains (3) summary
    cd04046
    Location:526 → 638
    C2_Calpain; C2 domain present in Calpain proteins
    cd00214
    Location:352 → 498
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    pfam00648
    Location:27 → 341
    Peptidase_C2; Calpain family cysteine protease

  6. XM_038632697.1 → XP_038488625.1  calpain-5 isoform X1

    Conserved Domains (3) summary
    cd04046
    Location:526 → 638
    C2_Calpain; C2 domain present in Calpain proteins
    cd00214
    Location:352 → 498
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    pfam00648
    Location:27 → 341
    Peptidase_C2; Calpain family cysteine protease

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049242.1 Alternate UU_Cfam_GSD_1.0

    Range
    21741079..21793561 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038568536.1 → XP_038424464.1  calpain-5 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JIX6, A0A8C0P1B0, A0A8P0SAV5
    Conserved Domains (3) summary
    cd04046
    Location:526 → 638
    C2_Calpain; C2 domain present in Calpain proteins
    cd00214
    Location:352 → 498
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    pfam00648
    Location:27 → 341
    Peptidase_C2; Calpain family cysteine protease

  2. XM_038568539.1 → XP_038424467.1  calpain-5 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JIX6, A0A8C0P1B0, A0A8P0SAV5
    Conserved Domains (3) summary
    cd04046
    Location:526 → 638
    C2_Calpain; C2 domain present in Calpain proteins
    cd00214
    Location:352 → 498
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    pfam00648
    Location:27 → 341
    Peptidase_C2; Calpain family cysteine protease

  3. XM_038568535.1 → XP_038424463.1  calpain-5 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JIX6, A0A8C0P1B0, A0A8P0SAV5
    Conserved Domains (3) summary
    cd04046
    Location:526 → 638
    C2_Calpain; C2 domain present in Calpain proteins
    cd00214
    Location:352 → 498
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    pfam00648
    Location:27 → 341
    Peptidase_C2; Calpain family cysteine protease

  4. XM_038568540.1 → XP_038424468.1  calpain-5 isoform X2

  5. XM_038568538.1 → XP_038424466.1  calpain-5 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JIX6, A0A8C0P1B0, A0A8P0SAV5
    Conserved Domains (3) summary
    cd04046
    Location:526 → 638
    C2_Calpain; C2 domain present in Calpain proteins
    cd00214
    Location:352 → 498
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    pfam00648
    Location:27 → 341
    Peptidase_C2; Calpain family cysteine protease

  6. XM_038568537.1 → XP_038424465.1  calpain-5 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JIX6, A0A8C0P1B0, A0A8P0SAV5
    Conserved Domains (3) summary
    cd04046
    Location:526 → 638
    C2_Calpain; C2 domain present in Calpain proteins
    cd00214
    Location:352 → 498
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    pfam00648
    Location:27 → 341
    Peptidase_C2; Calpain family cysteine protease

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006603.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    21453573..21506018 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005633461.3 → XP_005633518.1  calpain-5 isoform X1

    See identical proteins and their annotated locations for XP_005633518.1

    UniProtKB/TrEMBL
    A0A8C0JIX6, A0A8C0P1B0, A0A8P0SAV5
    Conserved Domains (3) summary
    cd04046
    Location:526 → 638
    C2_Calpain; C2 domain present in Calpain proteins
    cd00214
    Location:352 → 498
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    pfam00648
    Location:27 → 341
    Peptidase_C2; Calpain family cysteine protease

  2. XM_022407650.2 → XP_022263358.1  calpain-5 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JIX6, A0A8C0P1B0, A0A8P0SAV5
    Conserved Domains (3) summary
    cd04046
    Location:526 → 638
    C2_Calpain; C2 domain present in Calpain proteins
    cd00214
    Location:352 → 498
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    pfam00648
    Location:27 → 341
    Peptidase_C2; Calpain family cysteine protease

  3. XM_542293.7 → XP_542293.2  calpain-5 isoform X1

    See identical proteins and their annotated locations for XP_542293.2

    UniProtKB/TrEMBL
    A0A8C0JIX6, A0A8C0P1B0, A0A8P0SAV5
    Conserved Domains (3) summary
    cd04046
    Location:526 → 638
    C2_Calpain; C2 domain present in Calpain proteins
    cd00214
    Location:352 → 498
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    pfam00648
    Location:27 → 341
    Peptidase_C2; Calpain family cysteine protease

  4. XM_022407651.2 → XP_022263359.1  calpain-5 isoform X2

    Conserved Domains (3) summary
    cd04046
    Location:421 → 533
    C2_Calpain; C2 domain present in Calpain proteins
    cd00214
    Location:247 → 393
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    cl00051
    Location:64 → 236
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.

  5. XM_038456345.1 → XP_038312273.1  calpain-5 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JIX6, A0A8C0P1B0, A0A8P0SAV5
    Conserved Domains (3) summary
    cd04046
    Location:526 → 638
    C2_Calpain; C2 domain present in Calpain proteins
    cd00214
    Location:352 → 498
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    pfam00648
    Location:27 → 341
    Peptidase_C2; Calpain family cysteine protease

  6. XM_005633462.3 → XP_005633519.1  calpain-5 isoform X1

    See identical proteins and their annotated locations for XP_005633519.1

    UniProtKB/TrEMBL
    A0A8C0JIX6, A0A8C0P1B0, A0A8P0SAV5
    Conserved Domains (3) summary
    cd04046
    Location:526 → 638
    C2_Calpain; C2 domain present in Calpain proteins
    cd00214
    Location:352 → 498
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    pfam00648
    Location:27 → 341
    Peptidase_C2; Calpain family cysteine protease
Nucleotide Protein
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