PAK4 p21 (RAC1) activated kinase 4 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: PAK4provided by VGNC
Official Full Name: p21 (RAC1) activated kinase 4provided by VGNC
Primary source: VGNC:VGNC:53528
See related: Ensembl:ENSCAFG00845004765
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	1	NC_051805.1 (114608125..114651302, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	1	NC_006583.4 (113410153..113453319, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	1	NC_049222.1 (114794554..114837946, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	1	NC_049261.1 (114166259..114201907, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	1	NC_049742.1 (113799180..113842525, complement)

Chromosome 1 - NC_051805.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data demonstrate a novel association between Gab1 and Pak4 and identify Pak4 as a key integrator of cell migration and invasive growth downstream from the Met receptor.
Title: Pak4, a novel Gab1 binding partner, modulates cell migration and invasion by the Met receptor.

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Pathways from PubChem

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: serine/threonine-protein kinase PAK 4; LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 4

Names: p21(CDKN1A)-activated kinase 4

XP_005616659.1

EC 2.7.11.1

XP_038307755.1

EC 2.7.11.1

XP_038324112.1

EC 2.7.11.1

XP_038384864.1

EC 2.7.11.1

XP_038384865.1

EC 2.7.11.1

XP_038384866.1

EC 2.7.11.1

XP_038384867.1

EC 2.7.11.1

XP_038449142.1

EC 2.7.11.1

XP_038449143.1

EC 2.7.11.1

XP_038449144.1

EC 2.7.11.1

XP_038449145.1

EC 2.7.11.1

XP_038512964.1

EC 2.7.11.1

XP_038512965.1

EC 2.7.11.1

XP_038512966.1

EC 2.7.11.1

XP_038512967.1

EC 2.7.11.1

XP_541627.2

EC 2.7.11.1

XP_867241.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051805.1 Reference ROS_Cfam_1.0

Range

114608125..114651302 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038657036.1 → XP_038512964.1 serine/threonine-protein kinase PAK 4 isoform X1

UniProtKB/TrEMBL

A0A8C0S1R1, A0A8I3MLX7

Conserved Domains (2) summary

cd01093
Location:10 → 55

CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

cl21453
Location:301 → 592

PKc_like; Protein Kinases, catalytic domain
XM_038657039.1 → XP_038512967.1 serine/threonine-protein kinase PAK 4 isoform X2

UniProtKB/TrEMBL

A0A8C0YRA8, A0A8I3MU75, A0A8P0TLV0

Related

ENSCAFP00845006758.1, ENSCAFT00845008561.1

Conserved Domains (2) summary

cd01093
Location:10 → 55

CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

cl21453
Location:148 → 439

PKc_like; Protein Kinases, catalytic domain
XM_038657038.1 → XP_038512966.1 serine/threonine-protein kinase PAK 4 isoform X1

UniProtKB/TrEMBL

A0A8C0S1R1, A0A8I3MLX7

Conserved Domains (2) summary

cd01093
Location:10 → 55

CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

cl21453
Location:301 → 592

PKc_like; Protein Kinases, catalytic domain
XM_038657037.1 → XP_038512965.1 serine/threonine-protein kinase PAK 4 isoform X1

UniProtKB/TrEMBL

A0A8C0S1R1, A0A8I3MLX7

Related

ENSCAFP00845006752.1, ENSCAFT00845008553.1

Conserved Domains (2) summary

cd01093
Location:10 → 55

CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

cl21453
Location:301 → 592

PKc_like; Protein Kinases, catalytic domain

Alternate UMICH_Zoey_3.1

Genomic

NC_049261.1 Alternate UMICH_Zoey_3.1

Range

114166259..114201907 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038468184.1 → XP_038324112.1 LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 4 isoform X1

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049742.1 Alternate UNSW_CanFamBas_1.0

Range

113799180..113842525 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038593214.1 → XP_038449142.1 serine/threonine-protein kinase PAK 4 isoform X1

Conserved Domains (2) summary

cd01093
Location:10 → 55

CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

cl21453
Location:301 → 592

PKc_like; Protein Kinases, catalytic domain
XM_038593217.1 → XP_038449145.1 serine/threonine-protein kinase PAK 4 isoform X2

Conserved Domains (2) summary

cd01093
Location:10 → 55

CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

cl21453
Location:148 → 439

PKc_like; Protein Kinases, catalytic domain
XM_038593216.1 → XP_038449144.1 serine/threonine-protein kinase PAK 4 isoform X1

Conserved Domains (2) summary

cd01093
Location:10 → 55

CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

cl21453
Location:301 → 592

PKc_like; Protein Kinases, catalytic domain
XM_038593215.1 → XP_038449143.1 serine/threonine-protein kinase PAK 4 isoform X1

Conserved Domains (2) summary

cd01093
Location:10 → 55

CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

cl21453
Location:301 → 592

PKc_like; Protein Kinases, catalytic domain

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049222.1 Alternate UU_Cfam_GSD_1.0

Range

114794554..114837946 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038528936.1 → XP_038384864.1 serine/threonine-protein kinase PAK 4 isoform X1

UniProtKB/TrEMBL

A0A8C0KTR6, A0A8C0RM04, A0A8C0S1R1, A0A8P0N892

Conserved Domains (2) summary

cd01093
Location:10 → 55

CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

cl21453
Location:301 → 592

PKc_like; Protein Kinases, catalytic domain
XM_038528939.1 → XP_038384867.1 serine/threonine-protein kinase PAK 4 isoform X2

UniProtKB/TrEMBL

A0A8C0YRA8, A0A8I3MU75, A0A8P0TLV0

Conserved Domains (2) summary

cd01093
Location:10 → 55

CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

cl21453
Location:148 → 439

PKc_like; Protein Kinases, catalytic domain
XM_038528938.1 → XP_038384866.1 serine/threonine-protein kinase PAK 4 isoform X1

UniProtKB/TrEMBL

A0A8C0KTR6, A0A8C0RM04, A0A8C0S1R1, A0A8P0N892

Conserved Domains (2) summary

cd01093
Location:10 → 55

CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

cl21453
Location:301 → 592

PKc_like; Protein Kinases, catalytic domain
XM_038528937.1 → XP_038384865.1 serine/threonine-protein kinase PAK 4 isoform X1

UniProtKB/TrEMBL

A0A8C0KTR6, A0A8C0RM04, A0A8C0S1R1, A0A8P0N892

Conserved Domains (2) summary

cd01093
Location:10 → 55

CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

cl21453
Location:301 → 592

PKc_like; Protein Kinases, catalytic domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006583.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

113410153..113453319 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_541627.7 → XP_541627.2 serine/threonine-protein kinase PAK 4 isoform X1

See identical proteins and their annotated locations for XP_541627.2

UniProtKB/TrEMBL

A0A8C0KTR6, A0A8C0RM04, A0A8C0S1R1, A0A8P0N892

Conserved Domains (2) summary

cd01093
Location:10 → 55

CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

cl21453
Location:301 → 592

PKc_like; Protein Kinases, catalytic domain
XM_862148.6 → XP_867241.1 serine/threonine-protein kinase PAK 4 isoform X2

UniProtKB/TrEMBL

A0A8C0YRA8, A0A8I3MU75, A0A8P0TLV0

Conserved Domains (2) summary

cd01093
Location:10 → 55

CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

cl21453
Location:148 → 439

PKc_like; Protein Kinases, catalytic domain
XM_038451827.1 → XP_038307755.1 serine/threonine-protein kinase PAK 4 isoform X1

UniProtKB/TrEMBL

A0A8C0KTR6, A0A8C0RM04, A0A8C0S1R1, A0A8P0N892

Conserved Domains (2) summary

cd01093
Location:10 → 55

CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

cl21453
Location:301 → 592

PKc_like; Protein Kinases, catalytic domain
XM_005616602.4 → XP_005616659.1 serine/threonine-protein kinase PAK 4 isoform X1

See identical proteins and their annotated locations for XP_005616659.1

UniProtKB/TrEMBL

A0A8C0KTR6, A0A8C0RM04, A0A8C0S1R1, A0A8P0N892

Conserved Domains (2) summary

cd01093
Location:10 → 55

CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

cl21453
Location:301 → 592

PKc_like; Protein Kinases, catalytic domain