TIMP3 TIMP metallopeptidase inhibitor 3 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: TIMP3provided by VGNC
Official Full Name: TIMP metallopeptidase inhibitor 3provided by VGNC
Primary source: VGNC:VGNC:47377
See related: Ensembl:ENSCAFG00845010998
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: TIMP-3
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	10	NC_051814.1 (31469330..31523514, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	10	NC_006592.4 (30610166..30664261, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	10	NC_049231.1 (31684823..31738972, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	10	NC_049270.1 (31209878..31264020, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	10	NC_049751.1 (31499587..31553699, complement)

Chromosome 10 - NC_051814.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

three dimensional structure of canine TIMP-3 was generated and its interactions with MMP-2 and MMP-9, demonstrates the role of key binding residues
Title: Molecular Characterization and In-Silico Analysis of the Tissue Inhibitor of Metalloproteinases-3 (TIMP-3) Gene of Canine Mammary Tumor.

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General gene information

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Markers

EST8H11 (e-PCR)
- UniSTS:263436

REN79442 (e-PCR)
- UniSTS:404240

REN79443 (e-PCR)
- UniSTS:404241

ECD04505 (e-PCR)
- UniSTS:285577

D22S1555 (e-PCR)
- UniSTS:74903

TIMP3 (e-PCR)
- UniSTS:497825

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables metalloendopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protease binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of membrane protein ectodomain proteolysis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to organic substance	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: metalloproteinase inhibitor 3

Names: TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory); tissue inhibitor metalloproteinase-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001284439.1 → NP_001271368.1 metalloproteinase inhibitor 3 precursor

See identical proteins and their annotated locations for NP_001271368.1

Status: PROVISIONAL

Source sequence(s)

JF508171

UniProtKB/TrEMBL

A0A8C0JU96, A0A8C0MG55, A0A8I3NT63, A0A8P0TLT2, F5CBP3

Related

ENSCAFP00845015196.1, ENSCAFT00845019436.1

Conserved Domains (1) summary

cd03585
Location:24 → 200

NTR_TIMP; NTR domain, TIMP subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by ...