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PLCB3 phospholipase C beta 3 [ Canis lupus familiaris (dog) ]

Gene ID: 476034, updated on 5-Mar-2024

Summary

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Official Symbol
PLCB3provided by VGNC
Official Full Name
phospholipase C beta 3provided by VGNC
Primary source
VGNC:VGNC:52035
See related
Ensembl:ENSCAFG00845030670
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 18
Exon count:
31
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 18 NC_051822.1 (53839019..53854234, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 18 NC_006600.4 (51400704..51415897, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 18 NC_049239.1 (53301344..53316539, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 18 NC_049278.1 (52941907..52957083, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 18 NC_049759.1 (52517439..52532628, complement)

Chromosome 18 - NC_051822.1Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 137 Neighboring gene BCL2 associated agonist of cell death Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 14B Neighboring gene translation initiation factor IF-2 Neighboring gene FKBP prolyl isomerase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
XP_038281110.1
XP_038310122.1
XP_038357373.1
XP_038420056.1
XP_038484199.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051822.1 Reference ROS_Cfam_1.0

    Range
    53839019..53854234 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038425182.1 → XP_038281110.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KN21, A0A8C0MXB8, A0A8C0SKJ7, A0A8P0SR81
    Related
    ENSCAFP00845042801.1, ENSCAFT00845054456.1
    Conserved Domains (6) summary
    PRK00404
    Location:865 → 932
    tatB; Sec-independent protein translocase subunit TatB
    cd08591
    Location:316 → 693
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02952
    Location:318 → 833
    PLN02952; phosphoinositide phospholipase C
    cd13361
    Location:22 → 149
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16210
    Location:154 → 304
    EFh_PI-PLCbeta3; EF-hand motif found in phosphoinositide phospholipase C beta 3 (PI-PLC-beta3)
    pfam08703
    Location:1025 → 1197
    PLC-beta_C; PLC-beta C terminal

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049278.1 Alternate UMICH_Zoey_3.1

    Range
    52941907..52957083 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038501445.1 → XP_038357373.1  LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049759.1 Alternate UNSW_CanFamBas_1.0

    Range
    52517439..52532628 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038628271.1 → XP_038484199.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1

    Conserved Domains (6) summary
    PRK00404
    Location:865 → 932
    tatB; Sec-independent protein translocase subunit TatB
    cd08591
    Location:316 → 693
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02952
    Location:318 → 833
    PLN02952; phosphoinositide phospholipase C
    cd13361
    Location:22 → 149
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16210
    Location:154 → 304
    EFh_PI-PLCbeta3; EF-hand motif found in phosphoinositide phospholipase C beta 3 (PI-PLC-beta3)
    pfam08703
    Location:1025 → 1197
    PLC-beta_C; PLC-beta C terminal

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049239.1 Alternate UU_Cfam_GSD_1.0

    Range
    53301344..53316539 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038564128.1 → XP_038420056.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KN21, A0A8C0MXB8, A0A8C0SKJ7, A0A8P0SR81
    Conserved Domains (6) summary
    PRK00404
    Location:865 → 932
    tatB; Sec-independent protein translocase subunit TatB
    cd08591
    Location:316 → 693
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02952
    Location:318 → 833
    PLN02952; phosphoinositide phospholipase C
    cd13361
    Location:22 → 149
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16210
    Location:154 → 304
    EFh_PI-PLCbeta3; EF-hand motif found in phosphoinositide phospholipase C beta 3 (PI-PLC-beta3)
    pfam08703
    Location:1025 → 1197
    PLC-beta_C; PLC-beta C terminal

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006600.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    51400704..51415897 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038454194.1 → XP_038310122.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KN21, A0A8C0MXB8, A0A8C0SKJ7, A0A8P0SR81
    Conserved Domains (6) summary
    PRK00404
    Location:865 → 932
    tatB; Sec-independent protein translocase subunit TatB
    cd08591
    Location:316 → 693
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02952
    Location:318 → 833
    PLN02952; phosphoinositide phospholipase C
    cd13361
    Location:22 → 149
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16210
    Location:154 → 304
    EFh_PI-PLCbeta3; EF-hand motif found in phosphoinositide phospholipase C beta 3 (PI-PLC-beta3)
    pfam08703
    Location:1025 → 1197
    PLC-beta_C; PLC-beta C terminal
Nucleotide Protein
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