HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: HMGCRprovided by VGNC
Official Full Name: 3-hydroxy-3-methylglutaryl-CoA reductaseprovided by VGNC
Primary source: VGNC:VGNC:4034
Locus tag: CK820_G0009437
See related: Ensembl:ENSPTRG00000016994
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	4	NC_072402.2 (40675556..40699812, complement)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	5	NC_072403.1 (41094559..41118806, complement)

Chromosome 4 - NC_072402.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Markers

D5S1671E (e-PCR)
- UniSTS:151060

RH47294 (e-PCR)
- UniSTS:36389

GDB:177804 (e-PCR)
- UniSTS:154965

GDB:181537 (e-PCR)
- UniSTS:155263

D5S2670 (e-PCR)
- UniSTS:67513

A008K32 (e-PCR)
- UniSTS:61683

EST7D6 (e-PCR)
- UniSTS:263414

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables NADP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables hydroxymethylglutaryl-CoA reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in coenzyme A metabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in isoprenoid biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in sterol biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in peroxisomal membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: 3-hydroxy-3-methylglutaryl-Coenzyme A reductase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072402.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

40675556..40699812 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_016953130.4 → XP_016808619.4 3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform X1

UniProtKB/TrEMBL

A0A2J8NNH7, A0A8I3B1V8, K7B808, K7CRR5
XM_016953132.4 → XP_016808621.4 3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform X2

UniProtKB/TrEMBL

A0A2J8NNG0
XM_063810348.1 → XP_063666418.1 3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform X1

UniProtKB/TrEMBL

A0A2J8NNH7, A0A8I3B1V8, K7B808, K7CRR5
XM_054685018.2 → XP_054540993.2 3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform X1

UniProtKB/TrEMBL

A0A2J8NNH7, A0A8I3B1V8, K7B808, K7CRR5