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FYN FYN proto-oncogene, Src family tyrosine kinase [ Pan troglodytes (chimpanzee) ]

Gene ID: 462944, updated on 11-Apr-2024

Summary

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Official Symbol
FYNprovided by VGNC
Official Full Name
FYN proto-oncogene, Src family tyrosine kinaseprovided by VGNC
Primary source
VGNC:VGNC:9963
Locus tag
CK820_G0000509
See related
Ensembl:ENSPTRG00000018511
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 6
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 5 NC_072403.2 (123589986..123804362, complement)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 6 NC_072404.1 (123588470..123802780, complement)

Chromosome 5 - NC_072403.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC741253 Neighboring gene TRAF3 interacting protein 2 Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC134810216 Neighboring gene uncharacterized LOC134810349 Neighboring gene uncharacterized LOC107975361

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extrinsic component of cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tyrosine-protein kinase Fyn
Names
FYN oncogene related to SRC, FGR, YES
protein-tyrosine kinase fyn
XP_001159342.1
XP_009450134.1
XP_016811669.1
XP_016811672.1
XP_024213142.1
XP_054542165.1
XP_054542166.1
XP_063668710.1
XP_063668711.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072403.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    123589986..123804362 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_016956180.4 → XP_016811669.1  tyrosine-protein kinase Fyn isoform X1

    UniProtKB/TrEMBL
    A0A2I3SKP4, A0A2J8PU83, A0A2J8PU90, A0A6D2Y4M7
    Conserved Domains (3) summary
    cd10418
    Location:145 → 245
    SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
    cd12006
    Location:85 → 140
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    cd05070
    Location:261 → 534
    PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn

  2. XM_063812640.1 → XP_063668710.1  tyrosine-protein kinase Fyn isoform X2

    UniProtKB/TrEMBL
    A0A2J8PU76, A0A6D2WQY9, H2QTK7, K7B5S2

  3. XM_054686190.2 → XP_054542165.1  tyrosine-protein kinase Fyn isoform X1

    UniProtKB/TrEMBL
    A0A2I3SKP4, A0A2J8PU83, A0A6D2Y4M7

  4. XM_063812641.1 → XP_063668711.1  tyrosine-protein kinase Fyn isoform X2

    UniProtKB/TrEMBL
    A0A2J8PU76, A0A6D2WQY9, H2QTK7, K7B5S2

  5. XM_009451859.4 → XP_009450134.1  tyrosine-protein kinase Fyn isoform X2

    See identical proteins and their annotated locations for XP_009450134.1

    UniProtKB/TrEMBL
    A0A2J8PU76, A0A2J8PU90, A0A6D2WQY9, H2QTK7, K7B5S2
    Related
    ENSPTRP00000031615.4
    Conserved Domains (3) summary
    cd10368
    Location:145 → 245
    SH2_Src_Fyn; Src homology 2 (SH2) domain found in Fyn
    cd12006
    Location:85 → 140
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    cd05070
    Location:258 → 531
    PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn

  6. XM_001159342.7 → XP_001159342.1  tyrosine-protein kinase Fyn isoform X1

    See identical proteins and their annotated locations for XP_001159342.1

    UniProtKB/TrEMBL
    A0A2I3SKP4, A0A2J8PU83, A0A2J8PU90, A0A6D2Y4M7
    Conserved Domains (3) summary
    cd10418
    Location:145 → 245
    SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
    cd12006
    Location:85 → 140
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    cd05070
    Location:261 → 534
    PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn

  7. XM_016956183.4 → XP_016811672.1  tyrosine-protein kinase Fyn isoform X1

    UniProtKB/TrEMBL
    A0A2I3SKP4, A0A2J8PU83, A0A2J8PU90, A0A6D2Y4M7
    Related
    ENSPTRP00000077482.1
    Conserved Domains (3) summary
    cd10418
    Location:145 → 245
    SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
    cd12006
    Location:85 → 140
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    cd05070
    Location:261 → 534
    PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn

  8. XM_024357374.2 → XP_024213142.1  tyrosine-protein kinase Fyn isoform X1

    UniProtKB/TrEMBL
    A0A2I3SKP4, A0A2J8PU83, A0A2J8PU90, A0A6D2Y4M7
    Conserved Domains (3) summary
    cd10418
    Location:145 → 245
    SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
    cd12006
    Location:85 → 140
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    cd05070
    Location:261 → 534
    PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn

  9. XM_054686191.1 → XP_054542166.1  tyrosine-protein kinase Fyn isoform X1

    UniProtKB/TrEMBL
    A0A2I3SKP4, A0A2J8PU83, A0A6D2Y4M7
Nucleotide Protein
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