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PTPRC protein tyrosine phosphatase receptor type C [ Pan troglodytes (chimpanzee) ]

Gene ID: 457607, updated on 3-Apr-2024

Summary

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Official Symbol
PTPRCprovided by VGNC
Official Full Name
protein tyrosine phosphatase receptor type Cprovided by VGNC
Primary source
VGNC:VGNC:9888
Locus tag
CK820_G0038762
See related
Ensembl:ENSPTRG00000001817
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Also known as
CD45
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 1
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 1 NC_072398.2 (50335805..50454615, complement)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 1 NC_072398.1 (180868742..180987532)

Chromosome 1 - NC_072398.2Genomic Context describing neighboring genes Neighboring gene microRNA mir-181a-1 Neighboring gene microRNA mir-181b-1 Neighboring gene phosphatidylethanolamine-binding protein 1-like Neighboring gene ATPase H+ transporting V1 subunit G3 Neighboring gene NIMA related kinase 7 Neighboring gene proline-rich protein 13-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in synaptic membrane adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
receptor-type tyrosine-protein phosphatase C
XP_001141441.2
XP_001141776.2
XP_009438662.1
XP_009438667.1
XP_063650047.1
XP_063650056.1
XP_063650058.1
XP_063650064.1
XP_063650065.1
XP_063650068.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072398.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    50335805..50454615 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009440392.5 → XP_009438667.1  receptor-type tyrosine-protein phosphatase C isoform X3

    UniProtKB/TrEMBL
    A0A2I3SLS2
    Conserved Domains (6) summary
    PHA03255
    Location:27 → 165
    PHA03255; BDLF3; Provisional
    smart00194
    Location:586 → 845
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:614 → 845
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:419 → 499
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12453
    Location:7 → 32
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:171 → 227
    CD45; Leukocyte receptor CD45

  2. XM_009440387.5 → XP_009438662.1  receptor-type tyrosine-protein phosphatase C isoform X2

    UniProtKB/TrEMBL
    A0A2I3SLS2
    Conserved Domains (6) summary
    PHA03255
    Location:18 → 183
    PHA03255; BDLF3; Provisional
    smart00194
    Location:604 → 863
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:632 → 863
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:437 → 517
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12453
    Location:7 → 32
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:189 → 245
    CD45; Leukocyte receptor CD45

  3. XM_001141776.8 → XP_001141776.2  receptor-type tyrosine-protein phosphatase C isoform X1

    UniProtKB/TrEMBL
    A0A2I3SLS2, A0A2J8KHX2, A0A6D2X5H8, H2Q0U9
    Related
    ENSPTRP00000003034.5
    Conserved Domains (6) summary
    smart00194
    Location:944 → 1226
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:680 → 911
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:485 → 565
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12453
    Location:7 → 32
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:237 → 293
    CD45; Leukocyte receptor CD45
    cl25495
    Location:81 → 231
    Endomucin; Endomucin

  4. XM_063793988.1 → XP_063650058.1  receptor-type tyrosine-protein phosphatase C isoform X3

  5. XM_063793986.1 → XP_063650056.1  receptor-type tyrosine-protein phosphatase C isoform X2

  6. XM_063793977.1 → XP_063650047.1  receptor-type tyrosine-protein phosphatase C isoform X1

    UniProtKB/TrEMBL
    A0A2J8KHX2, A0A6D2X5H8, H2Q0U9

  7. XM_001141441.8 → XP_001141441.2  receptor-type tyrosine-protein phosphatase C isoform X5

    See identical proteins and their annotated locations for XP_001141441.2

    UniProtKB/TrEMBL
    A0A2I3S8S8, A0A2J8KHY4, A0A6D2XBE2, K7D3Y5
    Related
    ENSPTRP00000093765.1
    Conserved Domains (5) summary
    smart00194
    Location:783 → 1065
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:519 → 750
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:324 → 404
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12453
    Location:7 → 32
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:76 → 132
    CD45; Leukocyte receptor CD45

  8. XM_063793994.1 → XP_063650064.1  receptor-type tyrosine-protein phosphatase C isoform X4

  9. XM_063793998.1 → XP_063650068.1  receptor-type tyrosine-protein phosphatase C isoform X5

    UniProtKB/TrEMBL
    A0A2J8KHY4, A0A6D2XBE2, K7D3Y5

  10. XM_063793995.1 → XP_063650065.1  receptor-type tyrosine-protein phosphatase C isoform X4

Nucleotide Protein
Heading Accession and Version

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