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eIF3h eukaryotic translation initiation factor 3 subunit h [ Drosophila melanogaster (fruit fly) ]

Gene ID: 45682, updated on 26-Apr-2024

Summary

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Official Symbol
eIF3hprovided by FlyBase
Official Full Name
eukaryotic translation initiation factor 3 subunit hprovided by FlyBase
Primary source
FLYBASE:FBgn0022023
Locus tag
Dmel_CG9124
See related
AllianceGenome:FB:FBgn0022023
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GM14618; CG9124; Dmel\CG9124; eIF-3; eIF-3p40; eIf3-p44; eIF3-S3; EIF3H; eIF3p40; l(2)k09003; Q9U9Q4
Summary
Predicted to enable metal-dependent deubiquitinase activity. Predicted to contribute to translation initiation factor activity. Involved in positive regulation of Notch signaling pathway. Predicted to be located in cytosol. Predicted to be part of eukaryotic 43S preinitiation complex and eukaryotic translation initiation factor 3 complex. Predicted to be active in polysomal ribosome. Is expressed in adult head; adult heart; and organism. Human ortholog(s) of this gene implicated in breast cancer; prostate cancer; and prostate carcinoma. Orthologous to human EIF3H (eukaryotic translation initiation factor 3 subunit H). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
25C3-25C3; 2-15 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5051193..5053094, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5051193..5053094, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene SP555 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene senju Neighboring gene uncharacterized protein Neighboring gene Histone H3.3A Neighboring gene Neprilysin-like 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A genetic mosaic screen identifies genes modulating Notch signaling in Drosophila. Ren L, et al. PLoS One, 2018. PMID 30235233, Free PMC Article
  2. Sex lethal and upstream ORFs: a bait-and-trap system for ribosomes. Yao P, et al. Genome Biol, 2011 Jul 25. PMID 21787382, Free PMC Article
  3. The PIWI protein Aubergine recruits eIF3 to activate translation in the germ plasm. Ramat A, et al. Cell Res, 2020 May. PMID 32132673, Free PMC Article
  4. The TRC8 ubiquitin ligase is sterol regulated and interacts with lipid and protein biosynthetic pathways. Lee JP, et al. Mol Cancer Res, 2010 Jan. PMID 20068067, Free PMC Article
  5. Differential Requirement for Translation Initiation Factor Pathways during Ecdysone-Dependent Neuronal Remodeling in Drosophila. Rode S, et al. Cell Rep, 2018 Aug 28. PMID 30157424

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables metal-dependent deubiquitinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables metallopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
enables translation initiation factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational initiation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of eukaryotic 43S preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation initiation factor 3 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation initiation factor 3 complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 3 complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
eukaryotic translation initiation factor 3 subunit h
Names
CG9124-PA
CG9124-PB
eIF3h-PA
eIF3h-PB
eukaryotic initiation factor 3 p40 subunit
NP_524834.2
NP_995631.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    5051193..5053094 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080095.4 → NP_524834.2  eukaryotic translation initiation factor 3 subunit h, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524834.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C0PTU9, Q7KLX2, Q9U9Q4, Q9VMU9
    Related
    FBpp0078667
    Conserved Domains (1) summary
    cd08065
    Location:20 → 281
    MPN_eIF3h; Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in eIF2h

  2. NM_205909.3 → NP_995631.1  eukaryotic translation initiation factor 3 subunit h, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995631.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C0PTU9, Q7KLX2, Q9U9Q4, Q9VMU9
    Conserved Domains (1) summary
    cd08065
    Location:20 → 281
    MPN_eIF3h; Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in eIF2h
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9U9Q4.2 Q9U9Q4

Gene LinkOut

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