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TP53 tumor protein p53 [ Pan troglodytes (chimpanzee) ]

Gene ID: 455214, updated on 29-Mar-2024

Summary

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Official Symbol
TP53provided by VGNC
Official Full Name
tumor protein p53provided by VGNC
Primary source
VGNC:VGNC:9734
Locus tag
CK820_G0036775
See related
Ensembl:ENSPTRG00000008703
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 17
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 19 NC_072417.2 (18180360..18198707, complement)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 17 NC_072415.1 (16419856..16438203, complement)

Chromosome 19 - NC_072417.2Genomic Context describing neighboring genes Neighboring gene spermidine/spermine N1-acetyltransferase family member 2 Neighboring gene sex hormone binding globulin Neighboring gene ATPase Na+/K+ transporting subunit beta 2 Neighboring gene WD repeat containing antisense to TP53 Neighboring gene ephrin B3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Co-chaperon DnaJC7/TPR2 enhances p53 stability and activity through blocking the complex formation between p53 and MDM2. Kubo N, et al. Biochem Biophys Res Commun, 2013 Jan 18. PMID 23261415

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein tetramerization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
cellular tumor antigen p53
Names
tumor protein p53 (Li-Fraumeni syndrome)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072417.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    18180360..18198707 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001172077.6 → XP_001172077.2  cellular tumor antigen p53 isoform X2

    See identical proteins and their annotated locations for XP_001172077.2

    UniProtKB/TrEMBL
    A0A2J8KPA8, A0A2J8KPB3, A0A6D2Y7Y2, H2QC53
    Related
    ENSPTRP00000014836.4
    Conserved Domains (4) summary
    cd08367
    Location:109 → 288
    P53; P53 DNA-binding domain
    pfam18521
    Location:35 → 59
    TAD2; Transactivation domain 2
    pfam07710
    Location:319 → 355
    P53_tetramer; P53 tetramerisation motif
    pfam08563
    Location:6 → 30
    P53_TAD; P53 transactivation motif

  2. XM_016931470.3 → XP_016786959.2  cellular tumor antigen p53 isoform X1

    UniProtKB/TrEMBL
    A0A2I3S1V8
    Conserved Domains (2) summary
    pfam00870
    Location:113 → 307
    P53; P53 DNA-binding domain
    pfam07710
    Location:337 → 376
    P53_tetramer; P53 tetramerisation motif
Nucleotide Protein
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