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DBH dopamine beta-hydroxylase [ Canis lupus familiaris (dog) ]

Gene ID: 448806, updated on 5-Mar-2024

Summary

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Official Symbol
DBHprovided by VGNC
Official Full Name
dopamine beta-hydroxylaseprovided by VGNC
Primary source
VGNC:VGNC:39781
See related
Ensembl:ENSCAFG00845010802
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 9
Exon count:
12
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (50879184..50898677)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (49285838..49305131)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (50060855..50080372)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (49640508..49659973)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (49982444..50001971)

Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119876663 Neighboring gene ADAMTS like 2 Neighboring gene uncharacterized LOC119873347 Neighboring gene family with sequence similarity 163 member B Neighboring gene uncharacterized LOC111097472 Neighboring gene sarcosine dehydrogenase Neighboring gene U6 spliceosomal RNA Neighboring gene vav guanine nucleotide exchange factor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Canine tyrosine hydroxylase (TH) gene and dopamine beta -hydroxylase (DBH) gene: their sequences, genetic polymorphisms, and diversities among five different dog breeds. Takeuchi Y, et al. J Vet Med Sci, 2005 Sep. PMID 16210796

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables copper ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables dopamine beta-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in dopamine catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in norepinephrine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in octopamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in secretory granule membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
dopamine beta-hydroxylase
NP_001005263.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005263.1 → NP_001005263.1  dopamine beta-hydroxylase precursor

    See identical proteins and their annotated locations for NP_001005263.1

    Status: PROVISIONAL

    Source sequence(s)
    AB097057
    UniProtKB/Swiss-Prot
    Q68CI2
    UniProtKB/TrEMBL
    A0A8C0M129, A0A8C0PTZ7
    Related
    ENSCAFP00845014897.1, ENSCAFT00845019069.1
    Conserved Domains (3) summary
    pfam01082
    Location:207 → 333
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03351
    Location:50 → 163
    DOMON; DOMON domain
    pfam03712
    Location:352 → 508
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051813.1 Reference ROS_Cfam_1.0

    Range
    50879184..50898677
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049269.1 Alternate UMICH_Zoey_3.1

    Range
    49640508..49659973
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

    Range
    49982444..50001971
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

    Range
    50060855..50080372
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    49285838..49305131
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q68CI2.1 GenPept UniProtKB/Swiss-Prot:Q68CI2

Gene LinkOut

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Research Materials
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