eIF1A eukaryotic translation initiation factor 1A [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: eIF1Aprovided by FlyBase
Official Full Name: eukaryotic translation initiation factor 1Aprovided by FlyBase
Primary source: FLYBASE:FBgn0026250
Locus tag: Dmel_CG8053
See related: AllianceGenome:FB:FBgn0026250
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-EST:Liang-2.3; anon-EST:Posey4; CG8053; clone 2.3; D-eIF1A; D-eIF4c; Dmel\CG8053; eIF-1A; eIF-4c; EIF1A; EP(3)0935; EP935; group I; Group I; lincRNA.S7087
Summary: Predicted to enable translation initiation factor activity. Predicted to be involved in translational initiation. Located in cytosol and nucleoplasm. Is expressed in adult brain and adult brain cell body rind. Orthologous to human EIF1AX (eukaryotic translation initiation factor 1A X-linked) and EIF1AY (eukaryotic translation initiation factor 1A Y-linked). [provided by Alliance of Genome Resources, Apr 2022]
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (18274665..18283005)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (14100387..14108727)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

These data directly implicate translational repression in C9orf72 repeat-induced neurodegeneration and identify eIF1A as a novel modifier of C9orf72 repeat toxicity.
Title: C9orf72 arginine-rich dipeptide proteins interact with ribosomal proteins in vivo to induce a toxic translational arrest that is rescued by eIF1A.
reducing the function of eIF1A in spnB ovaries suppresses the ventralized eggshell phenotype by restoring Grk expression
Title: Repression of Gurken translation by a meiotic checkpoint in Drosophila oogenesis is suppressed by a reduction in the dose of eIF1A.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info
enables translation initiation factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in translation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational initiation	IEA Inferred from Electronic Annotation more info
involved_in translational initiation	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	HDA more info	PubMed
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of eukaryotic 43S preinitiation complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nucleoplasm	HDA more info	PubMed

Names: CG8053-PA; CG8053-PB; CG8053-PC; eIF1A-PA; eIF1A-PB; eIF1A-PC; eukaryotic initiation factor 1A; eukaryotic initiation factor 4c

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The following sections contain reference sequences that belong to a specific genome build. Explain