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ORF3a ORF3a protein [ Severe acute respiratory syndrome coronavirus 2 ]

Gene ID: 43740569, updated on 7-Apr-2024

Summary

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Gene symbol
ORF3a
Gene description
ORF3a protein
Locus tag
GU280_gp03
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Severe acute respiratory syndrome coronavirus 2 (isolate: Wuhan-Hu-1, nat-host: Homo sapiens)
Lineage
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; Betacoronavirus; Sarbecovirus
Summary
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, positive-sense, single-stranded RNA virus that causes coronavirus disease 2019 (COVID-19). Virus particles include the RNA genetic material and structural proteins needed for invasion of host cells. Once inside the cell the infecting RNA is used to encode structural proteins that make up virus particles, nonstructural proteins that direct virus assembly, transcription, replication and host control and accessory proteins whose function has not been determined.~ ORF3a encodes a viral accessory protein. Based on its similarity to other coronavirus proteins, ORF3a protein is thought to be a protein with ion channel activity (viroporin) that activates the NLRP3 inflammasome. ORF3a may also play a role in virus replication and pathogenesis.
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Genomic context

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Sequence:
NC_045512.2 (25393..26220)

NC_045512.2Genomic Context describing neighboring genes Neighboring gene ORF1a polyprotein;ORF1ab polyprotein Neighboring gene surface glycoprotein Neighboring gene envelope protein Neighboring gene membrane glycoprotein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_045512.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SARS-CoV-2 ORF3a sensitizes cells to ferroptosis via Keap1-NRF2 axis. Liu L, et al. Redox Biol, 2023 Jul. PMID 37245288, Free PMC Article
  2. Exploring polyamine interactions and binding pockets in SARS-CoV-2 ORF3a. Boonamnaj P, et al. J Mol Graph Model, 2023 Jul. PMID 37086515, Free PMC Article
  3. SARS-CoV-2 viral protein ORF3A injures renal tubules by interacting with TRIM59 to induce STAT3 activation. Cai H, et al. Mol Ther, 2023 Mar 1. PMID 36523164, Free PMC Article
  4. SARS-CoV-2 ORF3a inhibits cGAS-STING-mediated autophagy flux and antiviral function. Su J, et al. J Med Virol, 2023 Jan. PMID 36163413, Free PMC Article
  5. SARS-CoV-2 ORF3a Induces Incomplete Autophagy via the Unfolded Protein Response. Su WQ, et al. Viruses, 2021 Dec 9. PMID 34960736, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tetherin antagonism by SARS-CoV-2 ORF3a and spike protein enhances virus release.
    Title: Tetherin antagonism by SARS-CoV-2 ORF3a and spike protein enhances virus release.
  2. SARS-CoV-2 ORF3a-Mediated NF-kappaB Activation Is Not Dependent on TRAF-Binding Sequence.
    Title: SARS-CoV-2 ORF3a-Mediated NF-κB Activation Is Not Dependent on TRAF-Binding Sequence.
  3. SARS-CoV-2 ORF3a expression in brain disrupts the autophagy-lysosomal pathway, impairs sphingolipid homeostasis, and drives neuropathogenesis.
    Title: SARS-CoV-2 ORF3a expression in brain disrupts the autophagy-lysosomal pathway, impairs sphingolipid homeostasis, and drives neuropathogenesis.
  4. Genetic variety of ORF3a shapes SARS-CoV-2 fitness through modulation of lipid droplet.
    Title: Genetic variety of ORF3a shapes SARS-CoV-2 fitness through modulation of lipid droplet.
  5. Regulation of autophagy by SARS-CoV-2: The multifunctional contributions of ORF3a.
    Title: Regulation of autophagy by SARS-CoV-2: The multifunctional contributions of ORF3a.
  6. SARS-CoV-2 ORF3a sensitizes cells to ferroptosis via Keap1-NRF2 axis.
    Title: SARS-CoV-2 ORF3a sensitizes cells to ferroptosis via Keap1-NRF2 axis.
  7. Exploring polyamine interactions and binding pockets in SARS-CoV-2 ORF3a.
    Title: Exploring polyamine interactions and binding pockets in SARS-CoV-2 ORF3a.
  8. SARS-CoV-2 ORF3a positively regulates NF-kappaB activity by enhancing IKKbeta-NEMO interaction.
    Title: SARS-CoV-2 ORF3a positively regulates NF-κB activity by enhancing IKKβ-NEMO interaction.
  9. SARS-CoV-2 viral protein ORF3A injures renal tubules by interacting with TRIM59 to induce STAT3 activation.
    Title: SARS-CoV-2 viral protein ORF3A injures renal tubules by interacting with TRIM59 to induce STAT3 activation.
  10. SARS-CoV-2 ORF3a inhibits cGAS-STING-mediated autophagy flux and antiviral function.
    Title: SARS-CoV-2 ORF3a inhibits cGAS-STING-mediated autophagy flux and antiviral function.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General protein information

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Preferred Names
ORF3a protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_045512.2 Reference assembly

    Range
    25393..26220
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_009724391.1 ORF3a protein [Severe acute respiratory syndrome coronavirus 2]

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0DTC3
    UniProtKB/TrEMBL
    A0A679G5L0, A0A6C0MDI1, A0A6G7S6S0, A0A6H2LDA5, A0A6M3VXV1, A0A6M4BCN3, A0A6M4EMW1, A0A6M4N989, A0A6M4NAL3, A0A6M4NHY0, A0A6N1Q6C6, A0A6V7ALA6, A0A6V7ALH5, A0A7D5EKM9, A0A7D6BX51, A0A7D7Y6H8, A0A7H0ACM3, A0A7H0CWT4, A0A7H4JK51, A0A7L9W965, A0A7M1YCY0, A0A7S9FYX4, A0A7T4VWW0, A0A7T5EGD2, A0A7T8Q8R0, A0A7U0MLJ1, A0A7U1D8Z9, A0A7U2CPY4, A0A886N1W8, A0A894NIF9, A0A8A2RSQ6, A0A8B1GTG1
    Conserved Domains (1) summary
    cd21648
    Location:5 → 274
    SARS-CoV-like_ORF3a; accessory protein ORF3a of severe acute respiratory syndrome-associated coronavirus and similar proteins from related betacoronavirus
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0DTC3.1 P0DTC3

Gene LinkOut

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