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RORA RAR related orphan receptor A [ Gallus gallus (chicken) ]

Gene ID: 415377, updated on 3-Apr-2024

Summary

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Official Symbol
RORAprovided by CGNC
Official Full Name
RAR related orphan receptor Aprovided by CGNC
Primary source
CGNC:2749
See related
Ensembl:ENSGALG00010024646
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
RORalpha1
Summary
The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. [provided by RefSeq, Feb 2014]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 10
Exon count:
15
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 10 NC_052541.1 (4676286..5064573)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 10 NC_052582.1 (4550634..4938732)

Chromosome 10 - NC_052541.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121111660 Neighboring gene uncharacterized LOC124417120 Neighboring gene uncharacterized LOC121111661 Neighboring gene uncharacterized LOC107052149 Neighboring gene uncharacterized LOC124417124 Neighboring gene uncharacterized LOC121111665 Neighboring gene interactor of little elongation complex ELL subunit 2 Neighboring gene annexin A2 Neighboring gene forkhead box B1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Effect of the melatonin nuclear receptor RORα on monochromatic light-induced T-lymphocyte proliferation in chicken thymus. Xiong J, et al. Immunol Lett, 2019 Sep. PMID 31326445

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
nuclear receptor ROR-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289887.2 → NP_001276816.1  nuclear receptor ROR-alpha isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000245
    UniProtKB/TrEMBL
    A0A3Q2UCE3, A0A8V0ZYX9
    Related
    ENSGALP00010036935.1, ENSGALT00010060175.1
    Conserved Domains (2) summary
    cd06939
    Location:273 → 512
    NR_LBD_ROR_like; The ligand binding domain of Retinoid-related orphan receptors, of the nuclear receptor superfamily
    cd06968
    Location:67 → 161
    NR_DBD_ROR; DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers

  2. NM_001397360.1 → NP_001384289.1  nuclear receptor ROR-alpha isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000245
    UniProtKB/TrEMBL
    A0A8V0ZYX9, F1NML9
    Related
    ENSGALP00010036927.1, ENSGALT00010060167.1
    Conserved Domains (2) summary
    cd06939
    Location:217 → 456
    NR_LBD_ROR_like; The ligand binding domain of Retinoid-related orphan receptors, of the nuclear receptor superfamily
    cd06968
    Location:11 → 105
    NR_DBD_ROR; DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052541.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    4676286..5064573
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046899012.1 → XP_046754968.1  nuclear receptor ROR-alpha isoform X1

    UniProtKB/TrEMBL
    A0A3Q2UCE3
    Related
    ENSGALP00010036932.1, ENSGALT00010060172.1

  2. XM_004943750.5 → XP_004943807.3  nuclear receptor ROR-alpha isoform X2

    UniProtKB/TrEMBL
    A0A8V0ZYX9
    Conserved Domains (2) summary
    cd06939
    Location:212 → 449
    NR_LBD_ROR_like; The ligand binding domain of Retinoid-related orphan receptors, of the nuclear receptor superfamily
    cd06968
    Location:67 → 161
    NR_DBD_ROR; DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers

  3. XM_046899013.1 → XP_046754969.1  nuclear receptor ROR-alpha isoform X3

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052582.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    4550634..4938732
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046924766.1 → XP_046780722.1  nuclear receptor ROR-alpha isoform X1

    UniProtKB/TrEMBL
    A0A3Q2UCE3

  2. XM_046924767.1 → XP_046780723.1  nuclear receptor ROR-alpha isoform X2

  3. XM_046924768.1 → XP_046780724.1  nuclear receptor ROR-alpha isoform X3

Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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