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CACNA1D calcium voltage-gated channel subunit alpha1 D [ Bos taurus (cattle) ]

Gene ID: 408013, updated on 5-Mar-2024

Summary

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Official Symbol
CACNA1Dprovided by VGNC
Official Full Name
calcium voltage-gated channel subunit alpha1 Dprovided by VGNC
Primary source
VGNC:VGNC:26674
See related
BGD:BT10231; Ensembl:ENSBTAG00000010026
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 22
Exon count:
54
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 22 NC_037349.1 (47138335..47508935, complement)

Chromosome 22 - NC_037349.1Genomic Context describing neighboring genes Neighboring gene actin related protein 8 Neighboring gene interleukin 17 receptor B Neighboring gene choline dehydrogenase Neighboring gene transfer RNA histidin (anticodon GUG) Neighboring gene U2 spliceosomal RNA Neighboring gene microtubule-associated proteins 1A/1B light chain 3B-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037349.1 Chromosome 22 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Adrenal fasciculata cells express T-type and rapidly and slowly activating L-type Ca2+ channels that regulate cortisol secretion. Enyeart JJ, et al. Am J Physiol Cell Physiol, 2015 Jun 1. PMID 25788571, Free PMC Article
  2. Expression profile of the pore-forming subunits α1A and α1D in the foetal bovine hypothalamus: a mammal with a long gestation. Peruffo A, et al. Neurosci Lett, 2013 Nov 27. PMID 24148303
  3. Differential expression of calcium channel subtypes in the bovine adrenal medulla. García-Palomero E, et al. Neuroendocrinology, 2001 Oct. PMID 11598381
  4. Adrenal medulla calcium channel population is not conserved in bovine chromaffin cells in culture. Benavides A, et al. Neuroscience, 2004. PMID 15450357
  5. Greater diversity than previously thought of chromaffin cell Ca2+ channels, derived from mRNA identification studies. García-Palomero E, et al. FEBS Lett, 2000 Sep 22. PMID 11007970

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Adrenal fasciculata cells express Cav1.3 and Cav3.2 calcium channels that regulate cortisol secretion.
    Title: Adrenal fasciculata cells express T-type and rapidly and slowly activating L-type Ca2+ channels that regulate cortisol secretion.
  2. new information on the hypothalamic expression of alpha1A and alpha1D subunits during development in a mammal with a long gestation period and a large and convoluted brain.
    Title: Expression profile of the pore-forming subunits α1A and α1D in the foetal bovine hypothalamus: a mammal with a long gestation.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables high voltage-gated calcium channel activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium ion import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of voltage-gated calcium channel complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
voltage-dependent L-type calcium channel subunit alpha-1D
Names
voltage-gated calcium channel alpha 1D subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193025.1 → NP_001179954.1  voltage-dependent L-type calcium channel subunit alpha-1D

    See identical proteins and their annotated locations for NP_001179954.1

    Status: PROVISIONAL

    Source sequence(s)
    NKLS02000022
    UniProtKB/TrEMBL
    F1MTK5
    Related
    ENSBTAP00000013226.5, ENSBTAT00000013226.7
    Conserved Domains (4) summary
    pfam00520
    Location:143 → 417
    Ion_trans; Ion transport protein
    pfam08763
    Location:1568 → 1639
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1663 → 2180
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1503 → 1566
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037349.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    47138335..47508935 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010817680.3 → XP_010815982.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X10

    Conserved Domains (4) summary
    pfam00520
    Location:1222 → 1460
    Ion_trans; Ion transport protein
    pfam08763
    Location:1533 → 1604
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1628 → 2145
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1468 → 1531
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  2. XM_059879485.1 → XP_059735468.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X7

  3. XM_059879486.1 → XP_059735469.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X8

  4. XM_010817677.3 → XP_010815979.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X6

    Conserved Domains (4) summary
    pfam00520
    Location:1242 → 1480
    Ion_trans; Ion transport protein
    pfam08763
    Location:1553 → 1624
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1648 → 2165
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1488 → 1551
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  5. XM_059879483.1 → XP_059735466.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X4

  6. XM_010817674.3 → XP_010815976.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X1

    Conserved Domains (4) summary
    pfam00520
    Location:143 → 417
    Ion_trans; Ion transport protein
    pfam08763
    Location:1568 → 1639
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1663 → 2180
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1503 → 1566
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  7. XM_059879484.1 → XP_059735467.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X5

  8. XM_059879482.1 → XP_059735465.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X3

    UniProtKB/TrEMBL
    F1MTK5

  9. XM_059879487.1 → XP_059735470.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X11

  10. XM_005222722.5 → XP_005222779.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X9

    See identical proteins and their annotated locations for XP_005222779.1

    Related
    ENSBTAP00000090413.1, ENSBTAT00000127898.1
    Conserved Domains (4) summary
    pfam00520
    Location:1222 → 1460
    Ion_trans; Ion transport protein
    pfam08763
    Location:1533 → 1604
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1628 → 2136
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1468 → 1531
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  11. XM_059879481.1 → XP_059735464.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X2

    Related
    ENSBTAP00000101954.1, ENSBTAT00000130707.1
Nucleotide Protein Strain
Heading Accession and Version

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