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itga3a integrin, alpha 3a [ Danio rerio (zebrafish) ]

Gene ID: 407685, updated on 27-Mar-2024

Summary

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Official Symbol
itga3aprovided by ZNC
Official Full Name
integrin, alpha 3aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-090805-3
See related
Ensembl:ENSDARG00000037917 AllianceGenome:ZFIN:ZDB-GENE-090805-3
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to act upstream of or within cell adhesion and integrin-mediated signaling pathway. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of integrin complex. Orthologous to human ITGA3 (integrin subunit alpha 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 3
Exon count:
26
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (34846173..34917249)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (34716670..34787736)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene proteasome 26S subunit, non-ATPase 11a Neighboring gene cyclin dependent kinase 5, regulatory subunit 1a (p35) Neighboring gene carbonic anhydrase Xb Neighboring gene fatty acid-binding protein, heart-like Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. LMO1 Synergizes with MYCN to Promote Neuroblastoma Initiation and Metastasis. Zhu S, et al. Cancer Cell, 2017 Sep 11. PMID 28867147, Free PMC Article
  2. Zebrafish Collagen Type I: Molecular and Biochemical Characterization of the Major Structural Protein in Bone and Skin. Gistelinck C, et al. Sci Rep, 2016 Feb 15. PMID 26876635, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in leukocyte migration IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of integrin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of integrin complex IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Integrin alpha-3; integrin alpha-3
Names
integrin alpha 3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    34846173..34917249
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017354802.2 → XP_017210291.1  integrin alpha-3 isoform X1

    UniProtKB/TrEMBL
    A0A8M6YWS7

  2. XM_021474550.1 → XP_021330225.1  integrin alpha-3 isoform X2

    UniProtKB/TrEMBL
    A0A8M9QA60, F1R108
    Conserved Domains (2) summary
    smart00191
    Location:304 → 360
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:461 → 919
    Integrin_alpha2; Integrin alpha

  3. XM_005164095.4 → XP_005164152.1  integrin alpha-3 isoform X2

    See identical proteins and their annotated locations for XP_005164152.1

    UniProtKB/TrEMBL
    A0A8M9QA60, F1R108
    Conserved Domains (2) summary
    smart00191
    Location:304 → 360
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:461 → 919
    Integrin_alpha2; Integrin alpha

  4. XM_691769.9 → XP_696861.6  integrin alpha-3 isoform X2

    See identical proteins and their annotated locations for XP_696861.6

    UniProtKB/TrEMBL
    A0A8M9QA60, F1R108
    Related
    ENSDARP00000055262.5, ENSDART00000055263.6
    Conserved Domains (2) summary
    smart00191
    Location:304 → 360
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:461 → 919
    Integrin_alpha2; Integrin alpha
Nucleotide Protein Strain
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