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Rpn5 Regulatory particle non-ATPase 5 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40717, updated on 10-May-2024

Summary

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Official Symbol
Rpn5provided by FlyBase
Official Full Name
Regulatory particle non-ATPase 5provided by FlyBase
Primary source
FLYBASE:FBgn0028690
Locus tag
Dmel_CG1100
See related
AllianceGenome:FB:FBgn0028690
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1100; Dmel\CG1100; p55; rpn5; RPN5
Summary
Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of proteasome regulatory particle. Is expressed in adult head; adult heart; and organism. Orthologous to human PSMD12 (proteasome 26S subunit, non-ATPase 12). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
83C4-83C4; 3-47.5 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5789493..5791569)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1615215..1617291)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene jagunal Neighboring gene katanin p60-like 1 Neighboring gene Histone acetyltransferase 1 Neighboring gene Histone PARylation factor 1 Neighboring gene Proteasome assembly chaperone 1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic evidence linking age-dependent attenuation of the 26S proteasome with the aging process. Tonoki A, et al. Mol Cell Biol, 2009 Feb. PMID 19075009, Free PMC Article
  2. The proteasomal subunit Rpn6 is a molecular clamp holding the core and regulatory subcomplexes together. Pathare GR, et al. Proc Natl Acad Sci U S A, 2012 Jan 3. PMID 22187461, Free PMC Article
  3. Zn2+-induced reversible dissociation of subunit Rpn10/p54 of the Drosophila 26 S proteasome. Kiss P, et al. Biochem J, 2005 Oct 15. PMID 15946124, Free PMC Article
  4. Assembly of the Drosophila 26 S proteasome is accompanied by extensive subunit rearrangements. Kurucz E, et al. Biochem J, 2002 Jul 15. PMID 11945175, Free PMC Article
  5. The regulatory complex of Drosophila melanogaster 26S proteasomes. Subunit composition and localization of a deubiquitylating enzyme. Hölzl H, et al. J Cell Biol, 2000 Jul 10. PMID 10893261, Free PMC Article

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome regulatory particle IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome regulatory particle ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of proteasome regulatory particle, lid subcomplex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome regulatory particle, lid subcomplex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
regulatory particle non-ATPase 5
Names
CG1100-PA
Rpn5-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    5789493..5791569
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141331.3 → NP_649588.1  regulatory particle non-ATPase 5 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649588.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V3Z4
    Related
    FBpp0078278
    Conserved Domains (1) summary
    COG5071
    Location:13 → 496
    RPN5; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V3Z4 Q9V3Z4

Gene LinkOut

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