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hnrnpk heterogeneous nuclear ribonucleoprotein K [ Danio rerio (zebrafish) ]

Gene ID: 406267, updated on 27-Mar-2024

Summary

Official Symbol
hnrnpkprovided by ZNC
Official Full Name
heterogeneous nuclear ribonucleoprotein Kprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1926
See related
Ensembl:ENSDARG00000018914 AllianceGenome:ZFIN:ZDB-GENE-040426-1926
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
hnrpk; zgc:66162; wu:fb37h02; wu:fi34c04
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in regulation of mRNA splicing, via spliceosome and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in nucleoplasm. Predicted to be part of spliceosomal complex. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system; gut; otic vesicle; pectoral fin; and ventral mesoderm. Orthologous to human HNRNPK (heterogeneous nuclear ribonucleoprotein K). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

Location:
chromosome: 8
Exon count:
16
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (49745668..49766241, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (49756899..49777472, complement)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene G kinase anchoring protein 1 Neighboring gene Q-nucleotide N-glycosylase 1 Neighboring gene RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae) Neighboring gene neurotrophic tyrosine kinase, receptor, type 2a

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
heterogeneous nuclear ribonucleoprotein K

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212994.2NP_998159.2  heterogeneous nuclear ribonucleoprotein K

    See identical proteins and their annotated locations for NP_998159.2

    Status: VALIDATED

    Source sequence(s)
    BI704444, CR376792, CU682767, DR719329, EB912144
    UniProtKB/TrEMBL
    A0A8M3B580, F1QWB4
    Related
    ENSDARP00000088691.3, ENSDART00000097919.5
    Conserved Domains (3) summary
    cd00105
    Location:355418
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:122183
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    pfam08067
    Location:943
    ROKNT; ROKNT (NUC014) domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    49745668..49766241 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005167319.4XP_005167376.1  heterogeneous nuclear ribonucleoprotein K isoform X2

    UniProtKB/TrEMBL
    A0A2R8Q139, A0A8M2BEM9
    Related
    ENSDARP00000146195.1, ENSDART00000189142.1
    Conserved Domains (3) summary
    cd00105
    Location:343406
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:122183
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    pfam08067
    Location:943
    ROKNT; ROKNT (NUC014) domain
  2. XM_009304280.3XP_009302555.1  heterogeneous nuclear ribonucleoprotein K isoform X1

    See identical proteins and their annotated locations for XP_009302555.1

    UniProtKB/TrEMBL
    A0A8M3B580, F1QWB4
    Conserved Domains (3) summary
    cd00105
    Location:355418
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:122183
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    pfam08067
    Location:943
    ROKNT; ROKNT (NUC014) domain