CD44 CD44 molecule [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: CD44provided by VGNC
Official Full Name: CD44 moleculeprovided by VGNC
Primary source: VGNC:VGNC:51860
See related: Ensembl:ENSCAFG00845022357
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 18

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	18	NC_051822.1 (33345940..33436801, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	18	NC_006600.4 (32344254..32432780, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	18	NC_049239.1 (33135283..33223633, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	18	NC_049278.1 (32909118..32997479, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	18	NC_049759.1 (32494751..32582918, complement)

Chromosome 18 - NC_051822.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Immunohistochemistry was found to be a reliable technique for the detection of cancer stem cells in canine mammary neoplasms, and the frequency of these cells positively correlates with grades II and III tumors.
Title: Immunodetection of cells with a CD44+/CD24- phenotype in canine mammary neoplasms.
Although these findings suggest a role for this adhesion factor in canine mammary tumour development and progression, they also limit the use of this marker as a prognostic indicator.
Title: The role of CD44 adhesion factor in canine mammary carcinomas.
Adipose tissue-derived mesenchymal stem cells CD44, CD90, and MHC class I and were also partially positive for the expression of CD34; however, they did not express CD14 and CD45.
Title: Soluble factors-mediated immunomodulatory effects of canine adipose tissue-derived mesenchymal stem cells.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

CD44 (e-PCR), detects polymorphism
- UniSTS:262852

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cytokine receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables hyaluronic acid binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
part_of macrophage migration inhibitory factor receptor complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: CD44 antigen

Names: CD44 molecule (Indian blood group); ECMR-III; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; PGP-1; PGP-I; extracellular matrix receptor-III; hermes antigen; hyaluronate receptor; phagocytic glycoprotein 1; phagocytic glycoprotein I

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001197022.2 → NP_001183951.1 CD44 antigen precursor

Status: VALIDATED

Source sequence(s)

JAAUVH010000176

UniProtKB/TrEMBL

A0A8C0JWX8, A0A8C0SRU8

Conserved Domains (1) summary

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051822.1 Reference ROS_Cfam_1.0

Range

33345940..33436801 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038423381.1 → XP_038279309.1 CD44 antigen isoform X8

UniProtKB/TrEMBL

A0A8I3PC03, A0A8I3PG65, A0A8P0SC84

Related

ENSCAFP00845031004.1, ENSCAFT00845039566.1

Conserved Domains (1) summary

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_038423386.1 → XP_038279314.1 CD44 antigen isoform X13

UniProtKB/TrEMBL

A0A8C0SUP2, A0A8P0T2H3

Conserved Domains (2) summary

COG5422
Location:122 → 243

ROM1; RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_038423387.1 → XP_038279315.1 CD44 antigen isoform X14

UniProtKB/TrEMBL

A0A8C0SRU8

Conserved Domains (1) summary

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_038423384.1 → XP_038279312.1 CD44 antigen isoform X11

UniProtKB/TrEMBL

A0A8C0PRF5, A0A8C0SUP2

Conserved Domains (1) summary

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_038423388.1 → XP_038279316.1 CD44 antigen isoform X15

UniProtKB/TrEMBL

A0A8C0SRQ8

Conserved Domains (1) summary

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_038423379.1 → XP_038279307.1 CD44 antigen isoform X6

UniProtKB/TrEMBL

A0A8C0PB18

Related

ENSCAFP00845031961.1, ENSCAFT00845040820.1

Conserved Domains (1) summary

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_038423377.1 → XP_038279305.1 CD44 antigen isoform X4

UniProtKB/TrEMBL

A0A8C0PB18

Conserved Domains (1) summary

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_038423374.1 → XP_038279302.1 CD44 antigen isoform X1

UniProtKB/TrEMBL

A0A8C0PIQ0

Conserved Domains (1) summary

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_038423385.1 → XP_038279313.1 CD44 antigen isoform X12

Conserved Domains (1) summary

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_038423383.1 → XP_038279311.1 CD44 antigen isoform X10

UniProtKB/TrEMBL

A0A8C0PRB1

Conserved Domains (1) summary

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_038423378.1 → XP_038279306.1 CD44 antigen isoform X5

UniProtKB/TrEMBL

A0A8C0PRB1, A0A8P0P4J7

Related

ENSCAFP00845031833.1, ENSCAFT00845040668.1

Conserved Domains (1) summary

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_038423375.1 → XP_038279303.1 CD44 antigen isoform X2

UniProtKB/TrEMBL

A0A8C0PRB1, A0A8I3PRR1, A0A8P0NRG9

Related

ENSCAFP00845031293.1, ENSCAFT00845039963.1

Conserved Domains (1) summary

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_038423380.1 → XP_038279308.1 CD44 antigen isoform X7

UniProtKB/TrEMBL

A0A8I3PC03

Conserved Domains (1) summary

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_038423376.1 → XP_038279304.1 CD44 antigen isoform X3

UniProtKB/TrEMBL

A0A8I3PC03

Conserved Domains (1) summary

cd03516
Location:26 → 170

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_038423382.1 → XP_038279310.1 CD44 antigen isoform X9

UniProtKB/TrEMBL

A0A8I3PC03

Conserved Domains (1) summary

cd03516
Location:14 → 158

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...