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TP53 tumor protein p53 [ Canis lupus familiaris (dog) ]

Gene ID: 403869, updated on 5-Mar-2024

Summary

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Official Symbol
TP53provided by VGNC
Official Full Name
tumor protein p53provided by VGNC
Primary source
VGNC:VGNC:47719
See related
Ensembl:ENSCAFG00845024647
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
P53
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 5
Exon count:
11
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 5 NC_051809.1 (32665395..32678721, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 5 NC_006587.4 (32699559..32713071, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 5 NC_049226.1 (32768467..32781775, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 5 NC_049265.1 (32633092..32646601, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 5 NC_049746.1 (32589339..32602824, complement)

Chromosome 5 - NC_051809.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111095878 Neighboring gene ATPase Na+/K+ transporting subunit beta 2 Neighboring gene WD repeat containing antisense to TP53 Neighboring gene ephrin B3 Neighboring gene dynein axonemal heavy chain 2 Neighboring gene uncharacterized LOC111095879

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. p53 directs leader cell behavior, migration, and clearance during epithelial repair. Kozyrska K, et al. Science, 2022 Feb 11. PMID 35143293
  2. Canine tumor mutational burden is correlated with TP53 mutation across tumor types and breeds. Alsaihati BA, et al. Nat Commun, 2021 Aug 3. PMID 34344882, Free PMC Article
  3. Clinical significance of the two-base insertion mutation in the TP53 gene in canine histiocytic sarcoma. Asada H, et al. Res Vet Sci, 2019 Jun. PMID 30852355
  4. The intratumor heterogeneity of TP53 gene mutations in canine histiocytic sarcoma. Asada H, et al. J Vet Med Sci, 2019 Mar 14. PMID 30662044, Free PMC Article
  5. Establishment of TP53-knockout canine cells using optimized CRIPSR/Cas9 vector system for canine cancer research. Eun K, et al. BMC Biotechnol, 2019 Jan 3. PMID 30606176, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. p53 directs leader cell behavior, migration, and clearance during epithelial repair.
    Title: p53 directs leader cell behavior, migration, and clearance during epithelial repair.
  2. PGAM1 and TP53 mRNA levels in canine mammary carcinomas - Short communication.
    Title: PGAM1 and TP53 mRNA levels in canine mammary carcinomas - Short communication.
  3. p53, ER, and Ki67 Expression in Canine Mammary Carcinomas and Correlation With Pathological Variables and Prognosis.
    Title: p53, ER, and Ki67 Expression in Canine Mammary Carcinomas and Correlation With Pathological Variables and Prognosis.
  4. Canine tumor mutational burden is correlated with TP53 mutation across tumor types and breeds.
    Title: Canine tumor mutational burden is correlated with TP53 mutation across tumor types and breeds.
  5. We assessed the genomic landscape of canine hemangiosarcoma via whole-exome sequencing (47 golden retriever hemangiosarcomas) and RNA sequencing (74 hemangiosarcomas from multiple breeds). Somatic coding mutations occurred most frequently in the tumor suppressor TP53 (59.6% of cases) as well as two genes in the PI3K pathway: the oncogene PIK3CA (29.8%) and its regulatory subunit PIK3R1 (8.5%).
    Title: Comparative Genomics Reveals Shared Mutational Landscape in Canine Hemangiosarcoma and Human Angiosarcoma.
  6. This study suggested that histiocytic sarcoma (HS) cells might acquire the two-base insertion mutation (insAT) in the TP53 gene during development of metastasis, but insAT was not a prognostic factor in canine HS.
    Title: Clinical significance of the two-base insertion mutation in the TP53 gene in canine histiocytic sarcoma.
  7. Study established TP53-knockout canine cells using optimized CRIPSR/Cas9 vector system for canine cancer research. TP53 in canine cells was effectively and specifically targeted by the CRISPR/Cas9 system.
    Title: Establishment of TP53-knockout canine cells using optimized CRIPSR/Cas9 vector system for canine cancer research.
  8. TP53 mutations were not useful prognostic factors in this sample of canine cutaneous mast cell tumors
    Title: Prevalence and prognostic value of c-kit and TP53 mutations in canine mast cell tumours.
  9. the distribution of the tumor cells that harbor the TP53 gene mutations in the tumor tissues of dogs with histiocytic sarcoma
    Title: The intratumor heterogeneity of TP53 gene mutations in canine histiocytic sarcoma.
  10. These data suggest that the p53 mutant cell line CTBm2 could be a useful tool for analyzing the precise tetramerization mechanisms of p53 and verifying the effects of therapeutic agents against tumors expressing p53 mutants that lack the ability to tetramerize
    Title: Endogenous Leu332Gln mutation in p53 disrupts the tetramerization ability in a canine mammary gland tumor cell line.
Submit: New GeneRIF Correction See all GeneRIFs (28)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein tetramerization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
cellular tumor antigen p53
Names
mutant P53 tumor suppressor protein
tumor protein p53 (Li-Fraumeni syndrome)
tumor suppressor p53
tumor suppressor protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001389218.1 → NP_001376147.1  cellular tumor antigen p53

    Status: VALIDATED

    Source sequence(s)
    AB537893
    UniProtKB/Swiss-Prot
    Q29537, Q9TV78
    UniProtKB/TrEMBL
    A0A8C0K1L6, A0A8C0RLV2, E7FIY6, F1PI27
    Related
    ENSCAFP00845034138.1, ENSCAFT00845043577.1
    Conserved Domains (3) summary
    cd08367
    Location:96 → 277
    P53; P53 DNA-binding domain
    pfam07710
    Location:307 → 343
    P53_tetramer; P53 tetramerisation motif
    pfam08563
    Location:6 → 30
    P53_TAD; P53 transactivation motif

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051809.1 Reference ROS_Cfam_1.0

    Range
    32665395..32678721 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049265.1 Alternate UMICH_Zoey_3.1

    Range
    32633092..32646601 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049746.1 Alternate UNSW_CanFamBas_1.0

    Range
    32589339..32602824 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049226.1 Alternate UU_Cfam_GSD_1.0

    Range
    32768467..32781775 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006587.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    32699559..32713071 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001003210.1: Suppressed sequence

    Description
    NM_001003210.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q29537.2 GenPept UniProtKB/Swiss-Prot:Q29537

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.