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Ugt1a3 UDP glycosyltransferase 1 family, polypeptide A3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 396551, updated on 29-Feb-2024

Summary

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Official Symbol
Ugt1a3provided by RGD
Official Full Name
UDP glycosyltransferase 1 family, polypeptide A3provided by RGD
Primary source
RGD:1549728
See related
Ensembl:ENSRNOG00000018740 AllianceGenome:RGD:1549728
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ugt1; Ugt1a4; UDPGT 1-3
Summary
Predicted to enable glucuronosyltransferase activity. Involved in animal organ regeneration. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Orthologous to human UGT1A5 (UDP glucuronosyltransferase family 1 member A5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 2039.7), Kidney (RPKM 843.4) and 2 other tissues See more
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Genomic context

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Location:
9q35
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (96228134..96256264)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (88780328..88808465)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (95274707..95302822)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene UDP glucuronosyltransferase family 1 member A9 Neighboring gene uncharacterized LOC108351970 Neighboring gene UDP glucuronosyltransferase family 1 member A8 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A7C Neighboring gene UDP glucuronosyltransferase family 1 member A6 Neighboring gene UDP glycosyltransferase 1 family, polypeptide A4, pseudogene Neighboring gene UDP glucuronosyltransferase family 1 member A5 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A2 Neighboring gene DnaJ heat shock protein family (Hsp40) member B3 Neighboring gene UDP glucuronosyltransferase family 1 member A1 Neighboring gene maestro heat-like repeat family member 2A Neighboring gene Holliday junction recognition protein Neighboring gene transient receptor potential cation channel, subfamily M, member 8 Neighboring gene peptidylprolyl isomerase D, pseudogene 21

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Activity and expression of various isoforms of uridine diphosphate glucuronosyltransferase are differentially regulated during hepatic regeneration in rats. Tian H, et al. Pharm Res, 2005 Dec. PMID 16222444
  2. Isolation and sequencing of rat liver bilirubin UDP-glucuronosyltransferase cDNA: possible alternate splicing of a common primary transcript. Sato H, et al. Biochem Biophys Res Commun, 1990 May 31. PMID 2112380
  3. Drug-responsive and tissue-specific alternative expression of multiple first exons in rat UDP-glucuronosyltransferase family 1 (UGT1) gene complex. Emi Y, et al. J Biochem, 1995 Feb. PMID 7608130
  4. Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily. Mackenzie PI, et al. Pharmacogenet Genomics, 2005 Oct. PMID 16141793
  5. Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation. Zhang T, et al. Genome Res, 2004 Jan. PMID 14672974, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucuronosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glucuronosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in animal organ regeneration IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in bile acid secretion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular glucuronidation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular glucuronidation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in estrogen metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in vitamin D3 metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in xenobiotic glucuronidation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
UDP-glucuronosyltransferase 1A3
Names
B3
UDP glycosyltransferase 1 family polypeptide A4
UDP-glucuronosyltransferase 1-3
UDPGT
UGT1*3
UGT1-03
UGT1.3
NP_958827.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201424.2 → NP_958827.1  UDP-glucuronosyltransferase 1A3 precursor

    See identical proteins and their annotated locations for NP_958827.1

    Status: VALIDATED

    Source sequence(s)
    AC120922, AY435131
    UniProtKB/Swiss-Prot
    Q64637
    UniProtKB/TrEMBL
    Q6T5F1
    Related
    ENSRNOP00000046507.3, ENSRNOT00000045163.7
    Conserved Domains (2) summary
    PHA03392
    Location:228 → 505
    egt; ecdysteroid UDP-glucosyltransferase; Provisional
    pfam00201
    Location:26 → 522
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    96228134..96256264
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64637.1 GenPept UniProtKB/Swiss-Prot:Q64637

Gene LinkOut

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