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THRB thyroid hormone receptor beta [ Gallus gallus (chicken) ]

Gene ID: 396431, updated on 3-Apr-2024

Summary

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Symbol
THRBprovided by CGNC
Full Name
thyroid hormone receptor betaprovided by CGNC
Primary source
CGNC:49800
See related
Ensembl:ENSGALG00010001557
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
NR1A2; TR-BETA; CTR BETA 2
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
18
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (37164426..37332785, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (37215664..37384021, complement)

Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene NFKB inhibitor interacting Ras like 1 Neighboring gene ribosomal protein L15 Neighboring gene nuclear receptor subfamily 1 group D member 2 Neighboring gene uncharacterized LOC121109993 Neighboring gene retinoic acid receptor beta Neighboring gene uncharacterized LOC112531715 Neighboring gene topoisomerase (DNA) II beta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. changes occur in thyroid hormone (TH) receptor beta2 (TRbeta2) expression at the different levels of the hypothalamo-pituitary-thyroidal (HPT) axis during the last week of chicken embryonic development and hatching
    Title: Thyroid hormone receptor beta2 is strongly up-regulated at all levels of the hypothalamo-pituitary-thyroidal axis during late embryogenesis in chicken.
  2. Thyroid hormone receptor beta 2 mRNA is more abundant in the pituitary of newly hatched chicks than in 15-day-old embryos.
    Title: The use of real-time PCR to study the expression of thyroid hormone receptor beta 2 in the developing chicken.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in retinoic acid receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in thyroid hormone mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
thyroid hormone receptor beta
Names
C-ERBA-BETA
beta-thyroid hormone receptor
nuclear receptor subfamily 1 group A member 2
thyroid hormone receptor beta 2
thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252221.2 → NP_001239150.1  thyroid hormone receptor beta isoform 2

    See identical proteins and their annotated locations for NP_001239150.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting protein (isoform 2) is longer and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    BM490757, BU382230, JAENSK010000037
    UniProtKB/TrEMBL
    F1NWE9
    Related
    ENSGALP00010002023.1, ENSGALT00010003592.1
    Conserved Domains (2) summary
    cd06935
    Location:231 → 473
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:121 → 207
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

  2. NM_205447.2 → NP_990778.2  thyroid hormone receptor beta isoform 1

    See identical proteins and their annotated locations for NP_990778.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter protein (isoform 1).
    Source sequence(s)
    X17504, Z50188
    UniProtKB/Swiss-Prot
    P68306
    UniProtKB/TrEMBL
    A0A8V0X619
    Related
    ENSGALP00010002032.1, ENSGALT00010003607.1
    Conserved Domains (2) summary
    cd06935
    Location:124 → 366
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:14 → 100
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    37164426..37332785 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040677171.2 → XP_040533105.1  thyroid hormone receptor beta isoform X2

    UniProtKB/Swiss-Prot
    P68306
    UniProtKB/TrEMBL
    A0A8V0X619
    Conserved Domains (2) summary
    cd06935
    Location:124 → 366
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:14 → 100
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

  2. XM_046919416.1 → XP_046775372.1  thyroid hormone receptor beta isoform X1

    UniProtKB/TrEMBL
    A0A8V0X966

  3. XM_046919437.1 → XP_046775393.1  thyroid hormone receptor beta isoform X1

    UniProtKB/TrEMBL
    A0A8V0X966

  4. XM_025147070.3 → XP_025002838.1  thyroid hormone receptor beta isoform X2

    UniProtKB/Swiss-Prot
    P68306
    UniProtKB/TrEMBL
    A0A8V0X619
    Conserved Domains (2) summary
    cd06935
    Location:124 → 366
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:14 → 100
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

  5. XM_046919410.1 → XP_046775366.1  thyroid hormone receptor beta isoform X1

    UniProtKB/TrEMBL
    A0A8V0X966

  6. XM_040677142.2 → XP_040533076.1  thyroid hormone receptor beta isoform X2

    UniProtKB/Swiss-Prot
    P68306
    UniProtKB/TrEMBL
    A0A8V0X619
    Conserved Domains (2) summary
    cd06935
    Location:124 → 366
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:14 → 100
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

  7. XM_046919420.1 → XP_046775376.1  thyroid hormone receptor beta isoform X1

    UniProtKB/TrEMBL
    A0A8V0X966

  8. XM_046919447.1 → XP_046775403.1  thyroid hormone receptor beta isoform X2

    UniProtKB/Swiss-Prot
    P68306

  9. XM_046919407.1 → XP_046775363.1  thyroid hormone receptor beta isoform X1

    UniProtKB/TrEMBL
    A0A8V0X966

  10. XM_046919406.1 → XP_046775362.1  thyroid hormone receptor beta isoform X1

    UniProtKB/TrEMBL
    A0A8V0X966

  11. XM_025147069.3 → XP_025002837.1  thyroid hormone receptor beta isoform X2

    UniProtKB/Swiss-Prot
    P68306
    UniProtKB/TrEMBL
    A0A8V0X619
    Conserved Domains (2) summary
    cd06935
    Location:124 → 366
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:14 → 100
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

  12. XM_046919405.1 → XP_046775361.1  thyroid hormone receptor beta isoform X1

    UniProtKB/TrEMBL
    A0A8V0X966

  13. XM_046919446.1 → XP_046775402.1  thyroid hormone receptor beta isoform X2

    UniProtKB/Swiss-Prot
    P68306

  14. XM_046919411.1 → XP_046775367.1  thyroid hormone receptor beta isoform X1

    UniProtKB/TrEMBL
    A0A8V0X966

  15. XM_025147071.3 → XP_025002839.1  thyroid hormone receptor beta isoform X2

    UniProtKB/Swiss-Prot
    P68306
    UniProtKB/TrEMBL
    A0A8V0X619
    Conserved Domains (2) summary
    cd06935
    Location:124 → 366
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:14 → 100
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

  16. XM_046919418.1 → XP_046775374.1  thyroid hormone receptor beta isoform X1

    UniProtKB/TrEMBL
    A0A8V0X966
    Related
    ENSGALP00010002035.1, ENSGALT00010003612.1

  17. XM_025147072.3 → XP_025002840.1  thyroid hormone receptor beta isoform X2

    UniProtKB/Swiss-Prot
    P68306
    UniProtKB/TrEMBL
    A0A8V0X619
    Conserved Domains (2) summary
    cd06935
    Location:124 → 366
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:14 → 100
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

  18. XM_046919403.1 → XP_046775359.1  thyroid hormone receptor beta isoform X1

    UniProtKB/TrEMBL
    A0A8V0X966

  19. XM_015281324.4 → XP_015136810.1  thyroid hormone receptor beta isoform X2

    UniProtKB/Swiss-Prot
    P68306
    UniProtKB/TrEMBL
    A0A8V0X619
    Conserved Domains (2) summary
    cd06935
    Location:124 → 366
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:14 → 100
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

  20. XM_046919429.1 → XP_046775385.1  thyroid hormone receptor beta isoform X1

    UniProtKB/TrEMBL
    A0A8V0X966

  21. XM_046919454.1 → XP_046775410.1  thyroid hormone receptor beta isoform X2

    UniProtKB/Swiss-Prot
    P68306

  22. XM_046919455.1 → XP_046775411.1  thyroid hormone receptor beta isoform X2

    UniProtKB/Swiss-Prot
    P68306

  23. XM_025147073.3 → XP_025002841.1  thyroid hormone receptor beta isoform X2

    UniProtKB/Swiss-Prot
    P68306
    UniProtKB/TrEMBL
    A0A8V0X619
    Conserved Domains (2) summary
    cd06935
    Location:124 → 366
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:14 → 100
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

  24. XM_046919439.1 → XP_046775395.1  thyroid hormone receptor beta isoform X1

    UniProtKB/TrEMBL
    A0A8V0X966

  25. XM_040677133.2 → XP_040533067.1  thyroid hormone receptor beta isoform X2

    UniProtKB/Swiss-Prot
    P68306
    UniProtKB/TrEMBL
    A0A8V0X619
    Conserved Domains (2) summary
    cd06935
    Location:124 → 366
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:14 → 100
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

  26. XM_046919431.1 → XP_046775387.1  thyroid hormone receptor beta isoform X1

    UniProtKB/TrEMBL
    A0A8V0X966

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    37215664..37384021 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046910544.1 → XP_046766500.1  thyroid hormone receptor beta isoform X2

    UniProtKB/Swiss-Prot
    P68306

  2. XM_046910530.1 → XP_046766486.1  thyroid hormone receptor beta isoform X1

    UniProtKB/TrEMBL
    A0A8V0X966

  3. XM_046910535.1 → XP_046766491.1  thyroid hormone receptor beta isoform X1

    UniProtKB/TrEMBL
    A0A8V0X966

  4. XM_046910549.1 → XP_046766505.1  thyroid hormone receptor beta isoform X2

    UniProtKB/Swiss-Prot
    P68306

  5. XM_046910528.1 → XP_046766484.1  thyroid hormone receptor beta isoform X1

    UniProtKB/TrEMBL
    A0A8V0X966

  6. XM_046910542.1 → XP_046766498.1  thyroid hormone receptor beta isoform X2

    UniProtKB/Swiss-Prot
    P68306

  7. XM_046910532.1 → XP_046766488.1  thyroid hormone receptor beta isoform X1

    UniProtKB/TrEMBL
    A0A8V0X966

  8. XM_046910543.1 → XP_046766499.1  thyroid hormone receptor beta isoform X2

    UniProtKB/Swiss-Prot
    P68306

  9. XM_046910527.1 → XP_046766483.1  thyroid hormone receptor beta isoform X1

    UniProtKB/TrEMBL
    A0A8V0X966

  10. XM_046910526.1 → XP_046766482.1  thyroid hormone receptor beta isoform X1

    UniProtKB/TrEMBL
    A0A8V0X966

  11. XM_046910540.1 → XP_046766496.1  thyroid hormone receptor beta isoform X2

    UniProtKB/Swiss-Prot
    P68306

  12. XM_046910525.1 → XP_046766481.1  thyroid hormone receptor beta isoform X1

    UniProtKB/TrEMBL
    A0A8V0X966

  13. XM_046910541.1 → XP_046766497.1  thyroid hormone receptor beta isoform X2

    UniProtKB/Swiss-Prot
    P68306

  14. XM_046910529.1 → XP_046766485.1  thyroid hormone receptor beta isoform X1

    UniProtKB/TrEMBL
    A0A8V0X966

  15. XM_046910538.1 → XP_046766494.1  thyroid hormone receptor beta isoform X2

    UniProtKB/Swiss-Prot
    P68306

  16. XM_046910531.1 → XP_046766487.1  thyroid hormone receptor beta isoform X1

    UniProtKB/TrEMBL
    A0A8V0X966

  17. XM_046910539.1 → XP_046766495.1  thyroid hormone receptor beta isoform X2

    UniProtKB/Swiss-Prot
    P68306

  18. XM_046910524.1 → XP_046766480.1  thyroid hormone receptor beta isoform X1

    UniProtKB/TrEMBL
    A0A8V0X966

  19. XM_046910546.1 → XP_046766502.1  thyroid hormone receptor beta isoform X2

    UniProtKB/Swiss-Prot
    P68306

  20. XM_046910533.1 → XP_046766489.1  thyroid hormone receptor beta isoform X1

    UniProtKB/TrEMBL
    A0A8V0X966

  21. XM_046910536.1 → XP_046766492.1  thyroid hormone receptor beta isoform X1

    UniProtKB/TrEMBL
    A0A8V0X966

  22. XM_046910547.1 → XP_046766503.1  thyroid hormone receptor beta isoform X2

    UniProtKB/Swiss-Prot
    P68306

  23. XM_046910548.1 → XP_046766504.1  thyroid hormone receptor beta isoform X2

    UniProtKB/Swiss-Prot
    P68306

  24. XM_046910550.1 → XP_046766506.1  thyroid hormone receptor beta isoform X2

    UniProtKB/Swiss-Prot
    P68306

  25. XM_046910537.1 → XP_046766493.1  thyroid hormone receptor beta isoform X1

    UniProtKB/TrEMBL
    A0A8V0X966

  26. XM_046910545.1 → XP_046766501.1  thyroid hormone receptor beta isoform X2

    UniProtKB/Swiss-Prot
    P68306

  27. XM_046910534.1 → XP_046766490.1  thyroid hormone receptor beta isoform X1

    UniProtKB/TrEMBL
    A0A8V0X966
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P68306.1 GenPept UniProtKB/Swiss-Prot:P68306

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