FGA fibrinogen alpha chain [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: FGAprovided by CGNC
Official Full Name: fibrinogen alpha chainprovided by CGNC
Primary source: CGNC:49746
See related: Ensembl:ENSGALG00010014972
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: alpha-fibrinogen
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	4	NC_052535.1 (19787764..19794260, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	4	NC_052576.1 (19856740..19863634, complement)

Chromosome 4 - NC_052535.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hybrid human-chicken fibrinogen containing homologous chicken fibrinogen alpha chain can assemble into polymers that are similar to protofibrils, but these polymers are unable to assemble into fibrin fibers.
Title: Substitution of the human αC region with the analogous chicken domain generates a fibrinogen with severely impaired lateral aggregation: fibrin monomers assemble into protofibrils but protofibrils do not assemble into fibers.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in blood coagulation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in platelet activation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein polymerization	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of fibrinogen complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: fibrinogen alpha chain

Names: fibrinogen alpha subunit; fibrinogen alpha-E subunit; fibrinopeptide A; pre-fibrinogen alpha subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271911.2 → NP_001258840.2 fibrinogen alpha chain isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).

Source sequence(s)

JAENSK010000071

Related

ENSGALP00010020903.1, ENSGALT00010036010.1
NM_205356.2 → NP_990687.2 fibrinogen alpha chain isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' UTR, and uses an alternate exon structure in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to variant 1.

Source sequence(s)

BG641954, BU125048, JAENSK010000071, M34096

UniProtKB/TrEMBL

A0A8V0YJ17

Related

ENSGALP00010020910.1, ENSGALT00010036018.1

Conserved Domains (3) summary

pfam08192
Location:375 → 484

Peptidase_S64; Peptidase family S64

pfam08702
Location:50 → 191

Fib_alpha; Fibrinogen alpha/beta chain family

pfam12160
Location:299 → 364

Fibrinogen_aC; Fibrinogen alpha C domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052535.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

19787764..19794260 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052576.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

19856740..19863634 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)