PARP1 poly(ADP-ribose) polymerase 1 [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: PARP1provided by CGNC
Official Full Name: poly(ADP-ribose) polymerase 1provided by CGNC
Primary source: CGNC:7010
See related: Ensembl:ENSGALG00010017496
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: ADPRT; ARTD1; PARP-1
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	3	NC_052534.1 (16710070..16740072)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	3	NC_052575.1 (16624599..16654483)

Chromosome 3 - NC_052534.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that aryl hydrocarbon receptor (AHR) enhances phosphoenolpyruvate carboxykinase (PEPCK) ADP-ribosylation through TiPARP TiPARP (TCDD-inducible poly(ADP-ribose) polymerase).
Title: Aryl hydrocarbon receptor activation by dioxin targets phosphoenolpyruvate carboxykinase (PEPCK) for ADP-ribosylation via 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly(ADP-ribose) polymerase (TiPARP).
data indicate a novel role of PARP-1 in the transcriptional repression of integrated retroviruses
Title: Poly(ADP-ribose) polymerase 1 promotes transcriptional repression of integrated retroviruses.
Higher-eukaryotic cells separately employ PARP1 and Rad18 to suppress the toxic effects of NHEJ during the HR reaction at stalled replication forks.
Title: RAD18 and poly(ADP-ribose) polymerase independently suppress the access of nonhomologous end joining to double-strand breaks and facilitate homologous recombination-mediated repair.
PARG is identified as a novel and critical component of single-strand break repair that accelerates this process in concert with PARP-1.
Title: Poly(ADP-ribose) polymerase 1 accelerates single-strand break repair in concert with poly(ADP-ribose) glycohydrolase.
Results show that the 40 kDa carboxy terminus of poly(ADP-ribose) polymerase-1 forms a competent catalytic dimer in the absence of DNA, and that its automodification reaction is intermolecular.
Title: The 40 kDa carboxy-terminal domain of poly(ADP-ribose) polymerase-1 forms catalytically competent homo- and heterodimers in the absence of DNA.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables NAD binding	IEA Inferred from Electronic Annotation more info	PubMed
enables NAD+ ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: poly [ADP-ribose] polymerase 1

Names: ADP-ribosyltransferase NAD(+); ADP-ribosyltransferase diphtheria toxin-like 1; ADPRT 1; DNA ADP-ribosyltransferase PARP1; NAD(+) ADP-ribosyltransferase 1; TCDD-inducible poly(ADP-ribose) polymerase; poly (ADP-ribose) polymerase family, member 1; poly[ADP-ribose] synthase 1; poly[ADP-ribose] synthetase 1; protein poly-ADP-ribosyltransferase PARP1

NP_990594.3

EC 2.4.2.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.