CYP24A1 cytochrome P450 family 24 subfamily A member 1 [Gallus gallus (chicken)] - Gene

Summary

Symbol: CYP24A1provided by CGNC
Full Name: cytochrome P450 family 24 subfamily A member 1provided by CGNC
Primary source: CGNC:49500
See related: Ensembl:ENSGALG00010015154
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: CYP24; CP450CC24
Annotation information: Annotation category: suggests misassembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	20	NC_052551.1 (12690702..12698050)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	20	NC_052592.1 (12477269..12484634)

Chromosome 20 - NC_052551.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The distribution of vitamin D 1alpha- and 24-hydroxylase mRNA amounts was similar to mammals, and an immune stimulation altered the amounts of 1alpha- and 24-hydroxylase mRNA in chickens.
Title: Vitamin D-1α-hydroxylase and vitamin D-24-hydroxylase mRNA studies in chickens.
Effects of available phosphorus source and concentration on performance and expression of sodium phosphate type IIb cotransporter, vitamin D-1alpha-hydroxylase, and vitamin D-24-hydroxylase mRNA in broiler chicks.
Title: Effects of available phosphorus source and concentration on performance and expression of sodium phosphate type IIb cotransporter, vitamin D-1α-hydroxylase, and vitamin D-24-hydroxylase mRNA in broiler chicks.
data suggest that alternative splicing of vitamin D-24-hydroxylase (CYP24) leads to generation of a dominant negative-acting protein that is catalytically dysfunctional and may contribute to extracellular accumulation of 1,25-dihydroxyvitamin D
Title: Alternative splicing of vitamin D-24-hydroxylase: a novel mechanism for the regulation of extrarenal 1,25-dihydroxyvitamin D synthesis.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables heme binding	IEA Inferred from Electronic Annotation more info	PubMed
enables iron ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in C21-steroid hormone biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to peptide hormone stimulus	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cholesterol metabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cortisol metabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in glucocorticoid biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial

Names: 25-hydroxyvitamin D 24-hydroxylase; 25-hydroxyvitamin D3 24-hydroxylase; cytochrome P450, family 24, subfamily A, polypeptide 1

NP_001383216.1

EC 1.14.15.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001396287.1 → NP_001383216.1 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial

Status: VALIDATED

Source sequence(s)

AF019142, AF428109

UniProtKB/TrEMBL

O73684

Related

ENSGALP00010021272.1, ENSGALT00010036523.1

Conserved Domains (1) summary

cl12078
Location:48 → 494

p450; Cytochrome P450

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052551.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

12690702..12698050

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052592.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

12477269..12484634

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_204979.1: Suppressed sequence

Description

NM_204979.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.