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NR1H3 nuclear receptor subfamily 1 group H member 3 [ Gallus gallus (chicken) ]

Gene ID: 395221, updated on 3-Apr-2024

Summary

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Symbol
NR1H3provided by CGNC
Full Name
nuclear receptor subfamily 1 group H member 3provided by CGNC
Primary source
CGNC:49218
See related
Ensembl:ENSGALG00010022650
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
LXR; LXRA
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 5
Exon count:
11
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 5 NC_052536.1 (22647459..22675585, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 5 NC_052577.1 (22615391..22643485, complement)

Chromosome 5 - NC_052536.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 39 member 13 Neighboring gene myosin binding protein C3 Neighboring gene MAP kinase activating death domain Neighboring gene uncharacterized LOC121110999 Neighboring gene acid phosphatase 2, lysosomal Neighboring gene damage specific DNA binding protein 2 Neighboring gene protein kinase C and casein kinase substrate in neurons 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Fowl Adenovirus Serotype 4 Induces Hepatic Steatosis via Activation of Liver X Receptor-α. Yuan F, et al. J Virol, 2021 Feb 24. PMID 33361420, Free PMC Article
  2. Liver X receptor alpha regulates fatty acid synthase expression in chicken. Demeure O, et al. Poult Sci, 2009 Dec. PMID 19903962
  3. Cholesterol and bile acids regulate xenosensor signaling in drug-mediated induction of cytochromes P450. Handschin C, et al. J Biol Chem, 2002 Aug 16. PMID 12045201
  4. The mechanism mediating the activation of acetyl-coenzyme A carboxylase-alpha gene transcription by the liver X receptor agonist T0-901317. Talukdar S, et al. J Lipid Res, 2006 Nov. PMID 16931873
  5. Cholesterol secretion and homeostasis in chondrocytes: a liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein A1 expression. Gentili C, et al. Matrix Biol, 2005 Feb. PMID 15749000

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fowl Adenovirus Serotype 4 Induces Hepatic Steatosis via Activation of Liver X Receptor-alpha.
    Title: Fowl Adenovirus Serotype 4 Induces Hepatic Steatosis via Activation of Liver X Receptor-α.
  2. Results establish for the first time that LPCAT3 is specifically regulated by LXRalpha.
    Title: Regulation of LPCAT3 by LXR.
  3. These data define the chicken FASN gene as a direct target of LXRalpha and further expand the role of LXRalpha as a regulator of lipid metabolism in this species.
    Title: Liver X receptor alpha regulates fatty acid synthase expression in chicken.
  4. liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein A1 expression
    Title: Cholesterol secretion and homeostasis in chondrocytes: a liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein A1 expression.
  5. Liver X receptor alpha (LXR alpha) was expressed in chicken follicles; its expression patterns corresponded with SREBP-2 gene expression.
    Title: Modulation of sterol regulatory element binding protein-2 in response to rapid follicle development in chickens.
  6. T0-901317 increases hepatic ACC alpha transcription by directly activating LXR*retinoid X receptor (RXR) heterodimers and by increasing the activity of an accessory transcription factor (SREBP-1) that enhances ligand induced-LXR*RXR activity
    Title: The mechanism mediating the activation of acetyl-coenzyme A carboxylase-alpha gene transcription by the liver X receptor agonist T0-901317.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
oxysterols receptor LXR-alpha
Names
liver X receptor alpha
NP_989873.1
XP_040556484.1
XP_040556486.1
XP_046773618.1
XP_046773619.1
XP_046773620.1
XP_046797318.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204542.3 → NP_989873.1  oxysterols receptor LXR-alpha

    See identical proteins and their annotated locations for NP_989873.1

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000214
    UniProtKB/TrEMBL
    Q8AXU8, Q8JHU1
    Related
    ENSGALP00010033325.1, ENSGALT00010055107.1
    Conserved Domains (2) summary
    cd06954
    Location:172 → 407
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cd07160
    Location:40 → 140
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052536.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    22647459..22675585 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046941362.1 → XP_046797318.1  oxysterols receptor LXR-alpha isoform X1

    UniProtKB/TrEMBL
    Q8JHU1

  2. XM_040700550.2 → XP_040556484.1  oxysterols receptor LXR-alpha isoform X1

    UniProtKB/TrEMBL
    Q8AXU8, Q8JHU1
    Conserved Domains (2) summary
    cd06954
    Location:172 → 407
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cd07160
    Location:40 → 140
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers

  3. XM_040700552.2 → XP_040556486.1  oxysterols receptor LXR-alpha isoform X1

    UniProtKB/TrEMBL
    Q8AXU8, Q8JHU1
    Conserved Domains (2) summary
    cd06954
    Location:172 → 407
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cd07160
    Location:40 → 140
    NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052577.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    22615391..22643485 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046917663.1 → XP_046773619.1  oxysterols receptor LXR-alpha isoform X1

    UniProtKB/TrEMBL
    Q8JHU1

  2. XM_046917662.1 → XP_046773618.1  oxysterols receptor LXR-alpha isoform X1

    UniProtKB/TrEMBL
    Q8JHU1

  3. XM_046917664.1 → XP_046773620.1  oxysterols receptor LXR-alpha isoform X1

    UniProtKB/TrEMBL
    Q8JHU1
Nucleotide Protein Strain
Heading Accession and Version

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