ftcd formimidoyltransferase cyclodeaminase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ftcdprovided by ZNC
Official Full Name: formimidoyltransferase cyclodeaminaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-9643
See related: Ensembl:ENSDARG00000007421 AllianceGenome:ZFIN:ZDB-GENE-030131-9643
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:63647; wu:fp37b11
Summary: Predicted to enable folic acid binding activity; formimidoyltetrahydrofolate cyclodeaminase activity; and transferase activity. Predicted to be involved in histidine catabolic process to glutamate and formamide; histidine catabolic process to glutamate and formate; and tetrahydrofolate interconversion. Predicted to act upstream of or within histidine metabolic process. Located in Golgi apparatus. Is expressed in liver; pronephric duct; and yolk syncytial layer. Human ortholog(s) of this gene implicated in glutamate formiminotransferase deficiency. Orthologous to human FTCD (formimidoyltransferase cyclodeaminase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (12770876..12786531)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (12746099..12761754)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Formimidoyltransferase cyclodeaminase prevents the starvation-induced liver hepatomegaly and dysfunction through downregulating mTORC1.
Title: Formimidoyltransferase cyclodeaminase prevents the starvation-induced liver hepatomegaly and dysfunction through downregulating mTORC1.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables folic acid binding	IEA Inferred from Electronic Annotation more info
enables formimidoyltetrahydrofolate cyclodeaminase activity	IEA Inferred from Electronic Annotation more info
enables glutamate formimidoyltransferase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in histidine catabolic process to glutamate and formamide	IEA Inferred from Electronic Annotation more info
involved_in histidine catabolic process to glutamate and formate	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within histidine metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in centriole	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: formimidoyltransferase-cyclodeaminase

Names: formiminotransferase cyclodeaminase

NP_957371.2

EC 4.3.1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201077.2 → NP_957371.2 formimidoyltransferase-cyclodeaminase

Status: VALIDATED

Source sequence(s)

CF102927, EH487314, EH513708, EH525514

UniProtKB/TrEMBL

A0A8M1PIL2

Related

ENSDARP00000044682.4, ENSDART00000044683.5

Conserved Domains (4) summary

TIGR02024
Location:1 → 326

FtcD; glutamate formiminotransferase

pfam02971
Location:181 → 324

FTCD; Formiminotransferase domain

pfam04961
Location:339 → 520

FTCD_C; Formiminotransferase-cyclodeaminase

pfam07837
Location:7 → 179

FTCD_N; Formiminotransferase domain, N-terminal subdomain