U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Prim1 DNA primase subunit 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38942, updated on 26-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Prim1provided by FlyBase
Official Full Name
DNA primase subunit 1provided by FlyBase
Primary source
FLYBASE:FBgn0011762
Locus tag
Dmel_CG7108
See related
AllianceGenome:FB:FBgn0011762
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0140519.257; CG7108; Dmel\CG7108; Dmpol alpha; DNA polalpha; dnapol alpha 50; DNApol-alpha; DNApol-alpha50; DNApolalpha; DNApolalpha-50; DNApolalpha50; Dpri50; Pol; pol alpha; Pol-alpha50; POLA; polalpha; Polalpha; Polalpha 50kDa; Polalpha 50KDa; polalpha50; Polalpha50; PRI1
Summary
Enables DNA primase activity. Involved in DNA replication, synthesis of RNA primer. Part of alpha DNA polymerase:primase complex. Orthologous to human PRIM1 (DNA primase subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
66C7-66C8; 3-24 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8340314..8344404)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8333414..8337504)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Cuticular protein 66Cb Neighboring gene Peroxin 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene GTPase activating protein and centrosome-associated

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The 50-kDa primase subunit of Drosophila melanogaster DNA polymerase alpha. Molecular characterization of the gene and functional analysis of the overexpressed protein. Bakkenist CJ, et al. J Biol Chem, 1994 Oct 28. PMID 7929411
  2. The Drosophila melanogaster UMP-CMP kinase cDNA encodes an N-terminal mitochondrial import signal. Curbo S, et al. Biochem Biophys Res Commun, 2003 Nov 14. PMID 14592433
  3. Recollections of a DNA enzymologist. Lehman IR. Protein Sci, 1998 Apr. PMID 9568914, Free PMC Article
  4. Kinetics of deoxyribonucleotide insertion and extension at abasic template lesions in different sequence contexts using HIV-1 reverse transcriptase. Cai H, et al. J Biol Chem, 1993 Nov 5. PMID 7693691
  5. Synthesis by the DNA primase of Drosophila melanogaster of a primer with a unique chain length. Conaway RC, et al. Proc Natl Acad Sci U S A, 1982 Aug. PMID 6812052, Free PMC Article

See all (76) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA primase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA primase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA primase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA replication, synthesis of primer IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication, synthesis of primer IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA replication, synthesis of primer IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA-templated DNA replication IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of alpha DNA polymerase:primase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of alpha DNA polymerase:primase complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
DNA primase subunit 1
Names
CG7108-PA
DNA polymerase 50K
DNA polymerase alpha
DNA polymerase alpha 46,000 gamma subunit
DNA polymerase alpha 50 kda primase subunit
DNA polymerase alpha 50,000 gamma subunit
DNA polymerase alpha 50kD
DNA polymerase alpha 50kD subunit
DNA-polymerase alpha
Prim1-PA
p50 subunit of DNA polymerase alpha
NP_523972.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    8340314..8344404
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079248.4 → NP_523972.2  DNA primase subunit 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523972.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24317, Q9VSI0
    Related
    FBpp0076330
    Conserved Domains (1) summary
    cd04860
    Location:41 → 372
    AE_Prim_S; AE_Prim_S: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. Primases are DNA-dependent RNA polymerases which synthesis the short RNA primers required for DNA replication. In addition to its ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q24317.2 Q24317

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous