Trhn Tryptophan hydroxylase neuronal [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Trhnprovided by FlyBase
Official Full Name: Tryptophan hydroxylase neuronalprovided by FlyBase
Primary source: FLYBASE:FBgn0035187
Locus tag: Dmel_CG9122
See related: AllianceGenome:FB:FBgn0035187
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG9122; CT9937; Dmel\CG9122; dTrh; DTRH; DTRHn; trh; Trh; TrH; TRH; TRHn
Summary: Enables phenylalanine 4-monooxygenase activity and tryptophan 5-monooxygenase activity. Involved in several processes, including regulation of circadian sleep/wake cycle, sleep; serotonin biosynthetic process; and tracheal pit formation in open tracheal system. Predicted to be active in neuron projection. Is expressed in several structures, including adult abdomen; central nervous system; embryonic/larval nervous system; and serotonergic neurons. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; autistic disorder; borderline personality disorder; and mental depression (multiple). Orthologous to several human genes including TPH1 (tryptophan hydroxylase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 61F3-61F3; 3-0 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (1190384..1193173, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (1190384..1193173, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DTRH may be primarily neuronal in function and expression, and serve as an ancient conserved mechanism to appropriately regulate the production of serotonin in its target tissues.
Title: Serotonin synthesis by two distinct enzymes in Drosophila melanogaster.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen	IEA Inferred from Electronic Annotation more info
enables phenylalanine 4-monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables tryptophan 5-monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tryptophan 5-monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables tryptophan 5-monooxygenase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of adult feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of adult locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in aromatic amino acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of larval feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of heart rate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of circadian sleep/wake cycle, sleep	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of sensory perception of smell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in serotonin biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in serotonin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in serotonin biosynthetic process from tryptophan	IEP Inferred from Expression Pattern more info	PubMed
involved_in serotonin biosynthetic process from tryptophan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sleep	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tracheal pit formation in open tracheal system	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tryptophan hydroxylase neuronal

Names: CG9122-PA; Trhn-PA; tryptophan hydroxylase

NP_612080.1

EC 1.14.16.-

EC 1.14.16.1

EC 1.14.16.4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

1190384..1193173 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_138236.2 → NP_612080.1 tryptophan hydroxylase neuronal [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_612080.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9W0K2

Related

FBpp0072534

Conserved Domains (3) summary

TIGR01270
Location:34 → 509

Trp_5_monoox; tryptophan 5-monooxygenase, tetrameric

cd04929
Location:79 → 152

ACT_TPH; ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tryptophan hydroxylases (TPH), both peripheral (TPH1) and neuronal (TPH2) enzymes

pfam00351
Location:177 → 506

Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase