ITGB3 integrin subunit beta 3 [Gallus gallus (chicken)] - Gene

Summary

Symbol: ITGB3provided by CGNC
Full Name: integrin subunit beta 3provided by CGNC
Primary source: CGNC:223
See related: Ensembl:ENSGALG00010022837
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: integrin
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 27

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	27	NC_052558.1 (1955857..1973162)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	27	NC_052599.1 (3173630..3190932)

Chromosome 27 - NC_052558.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

alphavbeta3 integrin-targeted imaging agent enhances the visualization of ovarian tumor-associated angiogenic microvessels in hens with early-stage ovarian cancer.
Title: Enhancement of ovarian tumor detection with αvβ3 integrin-targeted ultrasound molecular imaging agent in laying hens: a preclinical model of spontaneous ovarian cancer.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables fibrinogen binding	IEA Inferred from Electronic Annotation more info	PubMed
enables fibronectin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables integrin binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion mediated by integrin	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell migration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell-matrix adhesion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info	PubMed
located_in focal adhesion	IEA Inferred from Electronic Annotation more info	PubMed
part_of integrin complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: integrin beta-3

Names: Integrin beta; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204315.2 → NP_989646.2 integrin beta-3 precursor

Status: VALIDATED

Source sequence(s)

JAENSK010000363

UniProtKB/TrEMBL

F1NS08, Q90829, Q92071

Related

ENSGALP00010033688.1, ENSGALT00010055604.1

Conserved Domains (1) summary

smart00187
Location:31 → 453

INB; Integrin beta subunits (N-terminal portion of extracellular region)