U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

VAV3 vav 3 guanine nucleotide exchange factor [ Gallus gallus (chicken) ]

Gene ID: 373939, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
VAV3provided by CGNC
Official Full Name
vav 3 guanine nucleotide exchange factorprovided by CGNC
Primary source
CGNC:1353
See related
Ensembl:ENSGALG00010011932
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 8
Exon count:
30
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 8 NC_052539.1 (1002266..1150420, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 8 NC_052580.1 (1008097..1156631, complement)

Chromosome 8 - NC_052539.1Genomic Context describing neighboring genes Neighboring gene netrin G1 Neighboring gene uncharacterized LOC112532929 Neighboring gene uncharacterized LOC112532928 Neighboring gene uncharacterized LOC107053912 Neighboring gene protein FAM102B-like Neighboring gene solute carrier family 25 member 24

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Tyrosine phosphorylation of 3BP2 is indispensable for the interaction with VAV3 in chicken DT40 cells. Chihara K, et al. Exp Cell Res, 2014 Mar 10. PMID 24406398
  2. Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activation. Inabe K, et al. J Exp Med, 2002 Jan 21. PMID 11805146, Free PMC Article
  3. Phospholipase C-gamma2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen. Weber M, et al. J Exp Med, 2008 Apr 14. PMID 18362175, Free PMC Article
  4. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. 3BP2 is involved in the activation of Rac1 through the regulation of Vav3 by Syk-dependent phosphorylation of Tyr(426) following BCR stimulation.
    Title: Tyrosine phosphorylation of 3BP2 is indispensable for the interaction with VAV3 in chicken DT40 cells.
  2. A key role for phospholipase C-gamma2 (PLCgamma2), Vav, B cell linker, and Bruton's tyrosine kinase in the formation of highly coordinated "microsignalosomes," , is identified.[
    Title: Phospholipase C-gamma2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
guanine nucleotide exchange factor VAV3
Names
vav 3 oncogene

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_206863.4 → NP_996745.1  guanine nucleotide exchange factor VAV3

    See identical proteins and their annotated locations for NP_996745.1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000237
    UniProtKB/TrEMBL
    A0A8V0YD40, Q8UUX6
    Related
    ENSGALP00010016410.1, ENSGALT00010028575.1
    Conserved Domains (7) summary
    cd10407
    Location:665 → 767
    SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
    cd11978
    Location:790 → 845
    SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
    cd11981
    Location:595 → 656
    SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
    cd00029
    Location:514 → 561
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01223
    Location:383 → 506
    PH_Vav; Vav pleckstrin homology (PH) domain
    pfam00307
    Location:2 → 115
    CH; Calponin homology (CH) domain
    pfam00621
    Location:196 → 370
    RhoGEF; RhoGEF domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052539.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    1002266..1150420 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025152727.3 → XP_025008495.1  guanine nucleotide exchange factor VAV3 isoform X3

    UniProtKB/TrEMBL
    A0A8V0YFB5
    Related
    ENSGALP00010016416.1, ENSGALT00010028584.1
    Conserved Domains (7) summary
    cd10407
    Location:636 → 738
    SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
    cd11978
    Location:789 → 844
    SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
    cd11981
    Location:566 → 627
    SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
    cd00029
    Location:485 → 532
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:193 → 363
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:363 → 477
    PH_Vav; Vav pleckstrin homology (PH) domain
    pfam11971
    Location:18 → 103
    CAMSAP_CH; CAMSAP CH domain

  2. XM_015290228.4 → XP_015145714.1  guanine nucleotide exchange factor VAV3 isoform X2

    UniProtKB/TrEMBL
    A0A8V0YD40
    Conserved Domains (7) summary
    cd10407
    Location:664 → 766
    SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
    cd11978
    Location:817 → 872
    SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
    cd11981
    Location:594 → 655
    SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
    cd00029
    Location:514 → 561
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01223
    Location:383 → 506
    PH_Vav; Vav pleckstrin homology (PH) domain
    pfam00307
    Location:2 → 115
    CH; Calponin homology (CH) domain
    pfam00621
    Location:196 → 370
    RhoGEF; RhoGEF domain

  3. XM_015290227.4 → XP_015145713.1  guanine nucleotide exchange factor VAV3 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Y6W5, A0A8V0YD40
    Related
    ENSGALP00010016408.1, ENSGALT00010028570.1
    Conserved Domains (7) summary
    cd10407
    Location:665 → 767
    SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
    cd11978
    Location:818 → 873
    SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
    cd11981
    Location:595 → 656
    SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
    cd00029
    Location:514 → 561
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01223
    Location:383 → 506
    PH_Vav; Vav pleckstrin homology (PH) domain
    pfam00307
    Location:2 → 115
    CH; Calponin homology (CH) domain
    pfam00621
    Location:196 → 370
    RhoGEF; RhoGEF domain

  4. XM_046944196.1 → XP_046800152.1  guanine nucleotide exchange factor VAV3 isoform X5

  5. XM_040704448.2 → XP_040560382.1  guanine nucleotide exchange factor VAV3 isoform X5

    UniProtKB/TrEMBL
    A0A8V0YD49
    Related
    ENSGALP00010016395.1, ENSGALT00010028557.1
    Conserved Domains (6) summary
    smart00109
    Location:427 → 475
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cd10407
    Location:578 → 680
    SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
    cd11978
    Location:731 → 786
    SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
    cd11981
    Location:508 → 569
    SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
    cd00160
    Location:106 → 282
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:296 → 419
    PH_Vav; Vav pleckstrin homology (PH) domain

  6. XM_025152728.3 → XP_025008496.2  guanine nucleotide exchange factor VAV3 isoform X4

    UniProtKB/TrEMBL
    A0A8V0YD35, A0A8V0YD40
    Related
    ENSGALP00010016405.1, ENSGALT00010028567.1
    Conserved Domains (6) summary
    smart00109
    Location:514 → 562
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cd10407
    Location:665 → 767
    SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
    cd11981
    Location:595 → 656
    SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
    cd00160
    Location:193 → 369
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:383 → 506
    PH_Vav; Vav pleckstrin homology (PH) domain
    pfam11971
    Location:18 → 103
    CAMSAP_CH; CAMSAP CH domain

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052580.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    1008097..1156631 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046922179.1 → XP_046778135.1  guanine nucleotide exchange factor VAV3 isoform X3

  2. XM_046922178.1 → XP_046778134.1  guanine nucleotide exchange factor VAV3 isoform X2

  3. XM_046922177.1 → XP_046778133.1  guanine nucleotide exchange factor VAV3 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Y6W5

  4. XM_046922182.1 → XP_046778138.1  guanine nucleotide exchange factor VAV3 isoform X5

  5. XM_046922181.1 → XP_046778137.1  guanine nucleotide exchange factor VAV3 isoform X5

  6. XM_046922180.1 → XP_046778136.1  guanine nucleotide exchange factor VAV3 isoform X4

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.