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Fzd8 frizzled class receptor 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 364754, updated on 5-Mar-2024

Summary

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Symbol
Fzd8provided by RGD
Full Name
frizzled class receptor 8provided by RGD
Primary source
RGD:1560525
See related
Ensembl:ENSRNOG00000069521 AllianceGenome:RGD:1560525
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including PDZ domain binding activity; Wnt-activated receptor activity; and Wnt-protein binding activity. Predicted to be involved in canonical Wnt signaling pathway and non-canonical Wnt signaling pathway. Predicted to act upstream of or within several processes, including T cell differentiation in thymus; angiogenesis; and positive regulation of JUN kinase activity. Predicted to be located in Golgi apparatus. Predicted to be part of Wnt-Frizzled-LRP5/6 complex. Predicted to be active in plasma membrane. Predicted to be integral component of membrane. Orthologous to human FZD8 (frizzled class receptor 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 88.1), Lung (RPKM 78.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
17q12.1
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (62007849..62015485)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (57312924..57320551)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (62259910..62267239)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene NSFL1 cofactor, pseudogene 1 Neighboring gene transfer RNA alanine (anticodon AGC) 37 Neighboring gene uncharacterized LOC134482860 Neighboring gene gap junction protein, delta 4 Neighboring gene cyclin Y

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Angiotensin-receptor blocker losartan alleviates atrial fibrillation in rats by downregulating frizzled 8 and inhibiting the activation of WNT-5A pathway. Feng R, et al. Clin Exp Pharmacol Physiol, 2023 Jan. PMID 36047789
  2. miR-375 regulates the canonical Wnt pathway through FZD8 silencing in arthritis synovial fibroblasts. Miao CG, et al. Immunol Lett, 2015 Mar. PMID 25619565
  3. Frizzled-8 as a putative therapeutic target in human lung cancer. Wang HQ, et al. Biochem Biophys Res Commun, 2012 Jan 6. PMID 22138402
  4. Structural basis of Wnt recognition by Frizzled. Janda CY, et al. Science, 2012 Jul 6. PMID 22653731, Free PMC Article
  5. Truncated mutants of the putative Wnt receptor LRP6/Arrow can stabilize beta-catenin independently of Frizzled proteins. Brennan K, et al. Oncogene, 2004 Jun 17. PMID 15064719, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Angiotensin-receptor blocker losartan alleviates atrial fibrillation in rats by downregulating frizzled 8 and inhibiting the activation of WNT-5A pathway.
    Title: Angiotensin-receptor blocker losartan alleviates atrial fibrillation in rats by downregulating frizzled 8 and inhibiting the activation of WNT-5A pathway.
  2. miR-375 regulates the canonical Wnt pathway through FZD8 silencing in arthritis synovial fibroblasts
    Title: miR-375 regulates the canonical Wnt pathway through FZD8 silencing in arthritis synovial fibroblasts.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC112790

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
  
enables Wnt receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Wnt receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables Wnt-protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Wnt-protein binding ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within T cell differentiation in thymus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in non-canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
part_of Wnt-Frizzled-LRP5/6 complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuronal dense core vesicle ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
frizzled-8
Names
frizzled family receptor 8
frizzled-8-like
fz-8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044251.2 → NP_001037716.1  frizzled-8 precursor

    See identical proteins and their annotated locations for NP_001037716.1

    Status: PROVISIONAL

    Source sequence(s)
    BC100088
    UniProtKB/Swiss-Prot
    Q498S8
    UniProtKB/TrEMBL
    A6KPN0
    Related
    ENSRNOP00000093389.1, ENSRNOT00000116071.1
    Conserved Domains (3) summary
    cd07461
    Location:31 → 155
    CRD_FZ8; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 8 (Fz8) receptor
    PHA03356
    Location:183 → 219
    PHA03356; tegument protein UL11; Provisional
    pfam01534
    Location:264 → 614
    Frizzled; Frizzled/Smoothened family membrane region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    62007849..62015485
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006254142.5 → XP_006254204.1  frizzled-8 isoform X1

    See identical proteins and their annotated locations for XP_006254204.1

    UniProtKB/Swiss-Prot
    Q498S8
    UniProtKB/TrEMBL
    A6KPN0
    Conserved Domains (3) summary
    cd07461
    Location:31 → 155
    CRD_FZ8; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 8 (Fz8) receptor
    PHA03356
    Location:183 → 219
    PHA03356; tegument protein UL11; Provisional
    pfam01534
    Location:264 → 614
    Frizzled; Frizzled/Smoothened family membrane region
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q498S8.1 GenPept UniProtKB/Swiss-Prot:Q498S8

Gene LinkOut

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