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Tnip1 TNFAIP3 interacting protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363599, updated on 3-Apr-2024

Summary

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Official Symbol
Tnip1provided by RGD
Official Full Name
TNFAIP3 interacting protein 1provided by RGD
Primary source
RGD:1309380
See related
Ensembl:ENSRNOG00000010370 AllianceGenome:RGD:1309380
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity; mitogen-activated protein kinase binding activity; and polyubiquitin modification-dependent protein binding activity. Predicted to be involved in several processes, including cellular response to lipopolysaccharide; negative regulation of intracellular signal transduction; and positive regulation of nitrogen compound metabolic process. Predicted to be located in cytosol and nucleoplasm. Orthologous to human TNIP1 (TNFAIP3 interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 289.7), Lung (RPKM 217.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
10q22
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (39537759..39585038, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (39037048..39084328, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (40255776..40303092, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene histidine triad nucleotide binding protein 1 Neighboring gene glutathione peroxidase 3 Neighboring gene 60S ribosomal protein L13-like Neighboring gene annexin A6 Neighboring gene uncharacterized LOC120095102

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKKgamma to dampen the host NF-kappaB-mediated inflammatory response. Ashida H, et al. Nat Cell Biol, 2010 Jan. PMID 20010814, Free PMC Article
  2. A new ERK2 binding protein, Naf1, attenuates the EGF/ERK2 nuclear signaling. Zhang S, et al. Biochem Biophys Res Commun, 2002 Sep 13. PMID 12220502
  3. Identification and cloning of a novel cellular protein Naf1, Nef-associated factor 1, that increases cell surface CD4 expression. Fukushi M, et al. FEBS Lett, 1999 Jan 8. PMID 9923610
  4. ABIN-1 binds to NEMO/IKKgamma and co-operates with A20 in inhibiting NF-kappaB. Mauro C, et al. J Biol Chem, 2006 Jul 7. PMID 16684768
  5. The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN. Heyninck K, et al. J Cell Biol, 1999 Jun 28. PMID 10385526, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables mitogen-activated protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mitogen-activated protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in MyD88-dependent toll-like receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycoprotein biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in leukocyte cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
TNFAIP3-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108826.1 → NP_001102296.1  TNFAIP3-interacting protein 1

    See identical proteins and their annotated locations for NP_001102296.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473948
    UniProtKB/TrEMBL
    A6HEJ9, D3ZHV1
    Conserved Domains (3) summary
    cl15254
    Location:467 → 515
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    cl19219
    Location:257 → 417
    DUF342; Protein of unknown function (DUF342)
    cl19252
    Location:229 → 266
    MreC; rod shape-determining protein MreC

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    39537759..39585038 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063269497.1 → XP_063125567.1  TNFAIP3-interacting protein 1 isoform X1

    UniProtKB/TrEMBL
    A6HEJ9, D3ZHV1

  2. XM_063269505.1 → XP_063125575.1  TNFAIP3-interacting protein 1 isoform X6

  3. XM_063269504.1 → XP_063125574.1  TNFAIP3-interacting protein 1 isoform X5

  4. XM_063269498.1 → XP_063125568.1  TNFAIP3-interacting protein 1 isoform X1

    UniProtKB/TrEMBL
    A6HEJ9, D3ZHV1

  5. XM_063269503.1 → XP_063125573.1  TNFAIP3-interacting protein 1 isoform X4

  6. XM_063269501.1 → XP_063125571.1  TNFAIP3-interacting protein 1 isoform X3

  7. XM_063269499.1 → XP_063125569.1  TNFAIP3-interacting protein 1 isoform X2

    UniProtKB/TrEMBL
    A6HEJ8

  8. XM_063269496.1 → XP_063125566.1  TNFAIP3-interacting protein 1 isoform X1

    UniProtKB/TrEMBL
    A6HEJ9, D3ZHV1

  9. XM_006246303.5 → XP_006246365.1  TNFAIP3-interacting protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006246365.1

    UniProtKB/TrEMBL
    A6HEJ9, D3ZHV1
    Related
    ENSRNOP00000013864.4
    Conserved Domains (3) summary
    cl15254
    Location:467 → 515
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    cl19219
    Location:257 → 417
    DUF342; Protein of unknown function (DUF342)
    cl19252
    Location:229 → 266
    MreC; rod shape-determining protein MreC

  10. XM_063269502.1 → XP_063125572.1  TNFAIP3-interacting protein 1 isoform X4

  11. XM_063269500.1 → XP_063125570.1  TNFAIP3-interacting protein 1 isoform X3

  12. XM_006246306.5 → XP_006246368.1  TNFAIP3-interacting protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006246368.1

    UniProtKB/TrEMBL
    A6HEJ8
    Conserved Domains (3) summary
    cl15254
    Location:467 → 515
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    cl19219
    Location:257 → 417
    DUF342; Protein of unknown function (DUF342)
    cl19252
    Location:229 → 266
    MreC; rod shape-determining protein MreC

  13. XM_063269506.1 → XP_063125576.1  TNFAIP3-interacting protein 1 isoform X7

Nucleotide Protein Strain
Heading Accession and Version

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