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eEF1alpha1 eukaryotic translation elongation factor 1 alpha 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36271, updated on 26-Apr-2024

Summary

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Official Symbol
eEF1alpha1provided by FlyBase
Official Full Name
eukaryotic translation elongation factor 1 alpha 1provided by FlyBase
Primary source
FLYBASE:FBgn0284245
Locus tag
Dmel_CG8280
See related
AllianceGenome:FB:FBgn0284245
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
0248; 1275; anon-EST:Liang-1.17; anon-EST:Liang-2.46; CG8280; chr2R:7409490..7409690; chr2R:7410009..7410129; clone 1.17; clone 2.46; Dm0084; DmEF1; Dmel\CG8280; eEF1a1; eEF1alpha; EF; EF-1; EF-1a; ef-1alpha; EF-1alpha; EF-1alpha F1; EF-1alphaF; EF-1alphaF1; EF-1alphaF[[1]]; EF-1[a]; Ef1; EF1; EF1-alpha; EF11_DROME; EF1A1; Ef1a10; Ef1a48D; EF1alpha; Ef1alpha 48D; EF1alpha 48D; Ef1alpha1; EF1alpha1; Ef1alpha48D; EF1alpha48D; Ef1alpha48E; Efalpha48D; F1; F1 EF-1alpha; l(2)00248; l(2)01275; l(2)1275; l(2)248; l(2)k07303
Summary
Predicted to enable GTPase activity and translation elongation factor activity. Involved in determination of adult lifespan. Predicted to be part of eukaryotic translation elongation factor 1 complex. Is expressed in several structures, including circulatory system; embryonic/larval lateral glial cell; head; imaginal disc; and prothoracic gland. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 38; developmental and epileptic encephalopathy 33; and ovarian cancer. Orthologous to several human genes including EEF1A2 (eukaryotic translation elongation factor 1 alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
48C5-48C5; 2-65 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11891135..11895762)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7778640..7783267)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene cutoff Neighboring gene Endoplasmic reticulum p60 Neighboring gene Microcephalin Neighboring gene Zinc/iron regulated transporter-related protein 48C Neighboring gene rebuf

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. EFFECTS ON FITNESS COMPONENTS OF P-ELEMENT INSERTS IN DROSOPHILA MELANOGASTER: ANALYSIS OF TRADE-OFFS. Stearns SC, et al. Evolution, 1996 Apr. PMID 28568924
  2. Effects on fitness components of enhanced expression of elongation factor EF-1alpha in Drosophila melanogaster. I. The contrasting approaches of molecular and population biologists. Stearns SC, et al. Am Nat, 1993 Dec. PMID 19425944
  3. A strong ubiquitous promoter-enhancer for development and aging of Drosophila melanogaster. Ackermann R, et al. Nucleic Acids Res, 1996 Jun 15. PMID 8710521, Free PMC Article
  4. Protein synthesis elongation factor EF-1 alpha expression and longevity in Drosophila melanogaster. Shikama N, et al. Proc Natl Acad Sci U S A, 1994 May 10. PMID 8183891, Free PMC Article
  5. The effects of enhanced expression of elongation factor EF-1 alpha on lifespan in Drosophila melanogaster. IV. A summary of three experiments. Stearns SC, et al. Genetica, 1993. PMID 8125267

See all (145) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Efficient binding of ZADs from the proteins Grau, ZIPIC, and Zw5 to the translation elongation factor EF1alpha1 in nuclear and cytoplasmic extracts has been demonstrated.
    Title: [Translation elongation factor EF1α1 interacts with ZAD domains of transcription factors from Drosophila melanogaster].
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables translation elongation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation elongation factor activity IEA
Inferred from Electronic Annotation
more info
  
enables translation elongation factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational elongation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational elongation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
part_of eukaryotic translation elongation factor 1 complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
eukaryotic translation elongation factor 1 alpha 1
Names
CG8280-PA
CG8280-PC
CG8280-PD
CG8280-PE
Ef1 alpha 48D
eEF1alpha1-PA
eEF1alpha1-PC
eEF1alpha1-PD
eEF1alpha1-PE
elongation factor 1 alpha
elongation factor 1 alpha 48D
elongation factor 1-alpha F1
elongation factor 1alpha48D
lethal (2) 00248
translational elongation factor1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    11891135..11895762
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299393.1 → NP_001286322.1  eukaryotic translation elongation factor 1 alpha 1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286322.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C6TP87, P08736, Q0E9B9, Q9V631
    Conserved Domains (1) summary
    PTZ00141
    Location:1 → 457
    PTZ00141; elongation factor 1- alpha; Provisional

  2. NM_165850.3 → NP_725085.1  eukaryotic translation elongation factor 1 alpha 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725085.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C6TP87, P08736, Q0E9B9, Q9V631
    Related
    FBpp0304260
    Conserved Domains (1) summary
    PTZ00141
    Location:1 → 457
    PTZ00141; elongation factor 1- alpha; Provisional

  3. NM_058027.5 → NP_477375.1  eukaryotic translation elongation factor 1 alpha 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477375.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C6TP87, P08736, Q0E9B9, Q9V631
    Related
    FBpp0087142
    Conserved Domains (1) summary
    PTZ00141
    Location:1 → 457
    PTZ00141; elongation factor 1- alpha; Provisional

  4. NM_001299392.1 → NP_001286321.1  eukaryotic translation elongation factor 1 alpha 1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286321.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C6TP87, P08736, Q0E9B9, Q9V631
    Conserved Domains (1) summary
    PTZ00141
    Location:1 → 457
    PTZ00141; elongation factor 1- alpha; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P08736.2 P08736
Q8T3U3 Q8T3U3

Gene LinkOut

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