U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

whd withered [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36109, updated on 26-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
whdprovided by FlyBase
Official Full Name
witheredprovided by FlyBase
Primary source
FLYBASE:FBgn0261862
Locus tag
Dmel_CG12891
See related
AllianceGenome:FB:FBgn0261862
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BEST:GH27794; CG12891; cpt1; Cpt1; CPT1; CPTI; dCPT1; Dmel\CG12891; gh27794
Summary
Predicted to enable carnitine O-palmitoyltransferase activity. Involved in response to metal ion; response to oxidative stress; and response to starvation. Located in endomembrane system. Is expressed in several structures, including embryonic epidermis; embryonic/larval central nervous system; embryonic/larval digestive system; extended germ band embryo; and fat body. Human ortholog(s) of this gene implicated in carnitine palmitoyltransferase I deficiency; hereditary spastic paraplegia 73; and lipid metabolism disorder. Orthologous to several human genes including CPT1A (carnitine palmitoyltransferase 1A) and CPT1B (carnitine palmitoyltransferase 1B). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
47A9-47A11; 2-62 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10469473..10478567, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6356978..6366072, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene G protein alpha subunit o Neighboring gene Cytochrome P450 49a1 Neighboring gene Chromatin assembly factor 1, p105 subunit Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45134 Neighboring gene translin Neighboring gene Peflin

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Alternative exon usage in the single CPT1 gene of Drosophila generates functional diversity in the kinetic properties of the enzyme: differential expression of alternatively spliced variants in Drosophila tissues. Price NT, et al. J Biol Chem, 2010 Mar 12. PMID 20061394, Free PMC Article
  2. Sequencing and functional expression of the malonyl-CoA-sensitive carnitine palmitoyltransferase from Drosophila melanogaster. Jackson VN, et al. Biochem J, 1999 Aug 1. PMID 10417309, Free PMC Article
  3. Transportin-serine/arginine-rich (Tnpo-SR) proteins are necessary for proper lipid storage in the Drosophila fat body. Nagle C, et al. Biochem Biophys Res Commun, 2022 Mar 12. PMID 35104661
  4. Glial β-oxidation regulates Drosophila energy metabolism. Schulz JG, et al. Sci Rep, 2015 Jan 15. PMID 25588812, Free PMC Article
  5. The role of SR protein kinases in regulating lipid storage in the Drosophila fat body. Mercier J, et al. Biochem Biophys Res Commun, 2023 Mar 15. PMID 36738578

See all (80) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. alternative splicing that specifically affects a structurally crucial region of the protein is an important mechanism through which functional diversity of CPT1 kinetics is generated from the single gene that occurs in insects
    Title: Alternative exon usage in the single CPT1 gene of Drosophila generates functional diversity in the kinetic properties of the enzyme: differential expression of alternatively spliced variants in Drosophila tissues.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables carnitine O-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in carnitine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to metal ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endomembrane system HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
withered
Names
CG12891-PA
CG12891-PB
CG12891-PC
CG12891-PD
carnitin-palmitoyl transferase-I
carnitine PalmitoylTransferase 1
carnitine-O-palmitoyltransferase
mitochondrial carnitine palamitoyltransferase I
mitochondrial carnitine palmitoyltransferase I
whd-PA
whd-PB
whd-PC
whd-PD
NP_001163111.1
NP_001163112.1
NP_523685.2
NP_724940.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    10469473..10478567 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078961.4 → NP_523685.2  withered, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523685.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JQH9
    Related
    FBpp0087399
    Conserved Domains (2) summary
    pfam00755
    Location:171 → 757
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
    pfam16484
    Location:1 → 45
    CPT_N; Carnitine O-palmitoyltransferase N-terminus

  2. NM_001169640.2 → NP_001163111.1  withered, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163111.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V3K9
    Conserved Domains (2) summary
    pfam00755
    Location:171 → 759
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
    pfam16484
    Location:1 → 45
    CPT_N; Carnitine O-palmitoyltransferase N-terminus

  3. NM_165777.3 → NP_724940.1  withered, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724940.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JQH9
    Related
    FBpp0087400
    Conserved Domains (2) summary
    pfam00755
    Location:171 → 757
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
    pfam16484
    Location:1 → 45
    CPT_N; Carnitine O-palmitoyltransferase N-terminus

  4. NM_001169641.2 → NP_001163112.1  withered, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163112.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V3K9
    Conserved Domains (2) summary
    pfam00755
    Location:171 → 759
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
    pfam16484
    Location:1 → 45
    CPT_N; Carnitine O-palmitoyltransferase N-terminus
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JQH9 Q7JQH9
Q9V3K9 Q9V3K9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous