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Hmgcl 3-Hydroxymethyl-3-methylglutaryl-CoA lyase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33978, updated on 26-Apr-2024

Summary

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Official Symbol
Hmgclprovided by FlyBase
Official Full Name
3-Hydroxymethyl-3-methylglutaryl-CoA lyaseprovided by FlyBase
Primary source
FLYBASE:FBgn0031877
Locus tag
Dmel_CG10399
See related
AllianceGenome:FB:FBgn0031877
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
145934_at; CG10399; Dmel\CG10399; HMGCL
Summary
Predicted to enable hydroxymethylglutaryl-CoA lyase activity. Predicted to be involved in ketone body biosynthetic process; leucine catabolic process; and lipid metabolic process. Predicted to be located in cytosol; endoplasmic reticulum; and peroxisome. Is expressed in adult head. Human ortholog(s) of this gene implicated in amino acid metabolic disorder. Orthologous to several human genes including HMGCLL1 (3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
27C7-27C7; 2-23 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6960377..6961653)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6960377..6961653)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Stromalin 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ada2a-containing complex component 1 Neighboring gene septin interacting protein 2 Neighboring gene Coproporphyrinogen oxidase Neighboring gene Small ubiquitin like modifier

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dietary citrate supplementation enhances longevity, metabolic health, and memory performance through promoting ketogenesis. Fan SZ, et al. Aging Cell, 2021 Dec. PMID 34719871, Free PMC Article
  2. Drosophila as a diet discovery tool for treating amino acid disorders. Mele S, et al. Trends Endocrinol Metab, 2023 Feb. PMID 36567227
  3. A Systematic Cell-Based Analysis of Localization of Predicted Drosophila Peroxisomal Proteins. Baron MN, et al. Traffic, 2016 May. PMID 26865094
  4. Rosy Beginnings: Studying Peroxisomes in Drosophila. Pridie C, et al. Front Cell Dev Biol, 2020. PMID 32984330, Free PMC Article
  5. Peroxisome Protein Prediction in Drosophila melanogaster. Anderson-Baron M, et al. Subcell Biochem, 2018. PMID 30378026

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables hydroxymethylglutaryl-CoA lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydroxymethylglutaryl-CoA lyase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables oxo-acid-lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-leucine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ketone body biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ketone body biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
3-Hydroxymethyl-3-methylglutaryl-CoA lyase
Names
CG10399-PA
CG10399-PB
Hmgcl-PA
Hmgcl-PB
NP_001285696.1
NP_609089.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    6960377..6961653
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298767.1 → NP_001285696.1  3-Hydroxymethyl-3-methylglutaryl-CoA lyase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285696.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4V3J3, Q9VM58
    Conserved Domains (2) summary
    cd07938
    Location:28 → 300
    DRE_TIM_HMGL; 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain
    pfam00682
    Location:25 → 299
    HMGL-like; HMGL-like

  2. NM_135245.3 → NP_609089.1  3-Hydroxymethyl-3-methylglutaryl-CoA lyase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609089.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4V3J3, Q9VM58
    Related
    FBpp0078979
    Conserved Domains (2) summary
    cd07938
    Location:28 → 300
    DRE_TIM_HMGL; 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain
    pfam00682
    Location:25 → 299
    HMGL-like; HMGL-like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VM58 Q9VM58

Gene LinkOut

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