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eIF3i eukaryotic translation initiation factor 3 subunit i [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33710, updated on 4-Apr-2024

Summary

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Official Symbol
eIF3iprovided by FlyBase
Official Full Name
eukaryotic translation initiation factor 3 subunit iprovided by FlyBase
Primary source
FLYBASE:FBgn0015834
Locus tag
Dmel_CG8882
See related
AllianceGenome:FB:FBgn0015834
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8882; Dmel\CG8882; DmTRIP; eIF-3beta; eIF-3i; eIF3-S2; SN2-9; Trip1; TRIP1
Summary
Predicted to enable translation initiation factor activity. Predicted to be involved in cytoplasmic translational initiation. Predicted to be part of eukaryotic translation initiation factor 3 complex, eIF3m. Is expressed in adult head; adult heart; organism; and ovary. Orthologous to human EIF3I (eukaryotic translation initiation factor 3 subunit I). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
25B5-25B5; 2-14 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (4966367..4967775, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (4966367..4967775, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Marcal1 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43824 Neighboring gene uncharacterized protein Neighboring gene Synthesis of cytochrome c oxidase Neighboring gene RNA polymerase I and III subunit C Neighboring gene lethal (2) 05714

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sex lethal and upstream ORFs: a bait-and-trap system for ribosomes. Yao P, et al. Genome Biol, 2011 Jul 25. PMID 21787382, Free PMC Article
  2. eIF4A inactivates TORC1 in response to amino acid starvation. Tsokanos FF, et al. EMBO J, 2016 May 17. PMID 26988032, Free PMC Article
  3. The essential Drosophila ATP-binding cassette domain protein, pixie, binds the 40 S ribosome in an ATP-dependent manner and is required for translation initiation. Andersen DS, et al. J Biol Chem, 2007 May 18. PMID 17392269
  4. Growth inhibition and differences in protein profiles in azadirachtin-treated Drosophila melanogaster larvae. Wang H, et al. Electrophoresis, 2014 Apr. PMID 24458307
  5. Assessment of genome-wide protein function classification for Drosophila melanogaster. Mi H, et al. Genome Res, 2003 Sep. PMID 12952880, Free PMC Article

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
enables translation initiation factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational initiation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 3 complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 3 complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of eukaryotic translation initiation factor 3 complex, eIF3m IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
eukaryotic translation initiation factor 3 subunit i
Names
CG8882-PA
Trip1
eIF3i-PA
suppressor of NA9 2-9

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    4966367..4967775 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078754.4 → NP_523478.1  eukaryotic translation initiation factor 3 subunit i [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523478.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O02195, Q540Y6, Q9VMX5
    Related
    FBpp0078689
    Conserved Domains (3) summary
    COG2319
    Location:9 → 313
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:13 → 50
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:6 → 313
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O02195.1 O02195

Gene LinkOut

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