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gsna gelsolin a [ Danio rerio (zebrafish) ]

Gene ID: 321099, updated on 25-Apr-2024

Summary

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Official Symbol
gsnaprovided by ZNC
Official Full Name
gelsolin aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-9653
See related
Ensembl:ENSDARG00000011459 AllianceGenome:ZFIN:ZDB-GENE-030131-9653
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
gsn; cb107; sb:cb107; u-gelsolin; wu:fi16f06
Summary
Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in several processes, including actin filament severing; actin polymerization or depolymerization; and barbed-end actin filament capping. Predicted to act upstream of or within actin filament capping; actin nucleation; and cell projection organization. Predicted to be located in cell projection and nucleus. Predicted to be active in actin cytoskeleton; cytoplasm; and extracellular space. Is expressed in several structures, including cardiovascular system; digestive system; nervous system; neural tube; and trigeminal placode. Human ortholog(s) of this gene implicated in Finnish type amyloidosis. Orthologous to human GSN (gelsolin). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 21
Exon count:
17
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (17569613..17603199, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (17535689..17566539, complement)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene general transcription factor IIIC, polypeptide 4 Neighboring gene BarH-like homeobox 1b Neighboring gene stomatin Neighboring gene retinoid X receptor, alpha a Neighboring gene dynein, axonemal, intermediate chain 1, paralog 2 Neighboring gene syntaxin 2a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Abundant corneal gelsolin in Zebrafish and the 'four-eyed' fish, Anableps anableps: possible analogy with multifunctional lens crystallins. Kanungo J, et al. Exp Eye Res, 2004 Dec. PMID 15642334, Free PMC Article
  2. Beta-thymosin, a modulator of the actin cytoskeleton is increased in regenerating retinal ganglion cells. Roth LW, et al. Eur J Neurosci, 1999 Oct. PMID 10564357
  3. Duplicated gelsolin family genes in zebrafish: a novel scinderin-like gene (scinla) encodes the major corneal crystallin. Jia S, et al. FASEB J, 2007 Oct. PMID 17548429, Free PMC Article
  4. fgf20 is essential for initiating zebrafish fin regeneration. Whitehead GG, et al. Science, 2005 Dec 23. PMID 16373575
  5. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within actin filament capping IEA
Inferred from Electronic Annotation
more info
  
involved_in actin filament severing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in barbed-end actin filament capping IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell projection assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
gelsolin a; gelsolin
Names
gelsolin (amyloidosis, Finnish type)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012312.2 → NP_001012312.2  gelsolin a

    Status: VALIDATED

    Source sequence(s)
    CN326697, CR762400, EB933070, EH436982, EH457619, EH462972
    UniProtKB/TrEMBL
    A0A0R4IZW1, A0A8N7UY51, F1QNL5, F1QUM3
    Related
    ENSDARP00000026895.6, ENSDART00000020048.8
    Conserved Domains (6) summary
    cd11288
    Location:509 → 597
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:135 → 223
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:7 → 119
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:613 → 711
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:243 → 343
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:387 → 487
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    17569613..17603199 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021468752.1 → XP_021324427.1  gelsolin isoform X1

    UniProtKB/TrEMBL
    A0A8M9P366
    Related
    ENSDARP00000144376.1, ENSDART00000177270.2
    Conserved Domains (6) summary
    cd11288
    Location:518 → 606
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:135 → 223
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:7 → 119
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:622 → 720
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:243 → 343
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:387 → 496
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395085.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    291579..322429 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395347.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    62396..93246 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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