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ppardb peroxisome proliferator-activated receptor delta b [ Danio rerio (zebrafish) ]

Gene ID: 30754, updated on 11-Apr-2024

Summary

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Official Symbol
ppardbprovided by ZNC
Official Full Name
peroxisome proliferator-activated receptor delta bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-000112-47
See related
Ensembl:ENSDARG00000009473 AllianceGenome:ZFIN:ZDB-GENE-000112-47
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
pparb2; fc59g04; fk47c06; wu:fc59g04; wu:fk47c06
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and nuclear receptor activity. Predicted to be involved in several processes, including negative regulation of cholesterol storage; positive regulation of fatty acid metabolic process; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of transcription, DNA-templated. Predicted to be located in nucleus. Is expressed in brain; intestine; liver; and ovary. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PPARD (peroxisome proliferator activated receptor delta). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 8
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (23703380..23725047)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (23682156..23703808)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene complement factor properdin Neighboring gene si:ch73-237c6.1 Neighboring gene makorin, ring finger protein, 4 Neighboring gene FA complementation group E

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Live cell screening platform identifies PPARδ as a regulator of cardiomyocyte proliferation and cardiac repair. Magadum A, et al. Cell Res, 2017 Aug. PMID 28621328, Free PMC Article
  2. Developmental exposures to perfluorooctanesulfonic acid (PFOS) impact embryonic nutrition, pancreatic morphology, and adiposity in the zebrafish, Danio rerio. Sant KE, et al. Environ Pollut, 2021 Apr 15. PMID 33581636, Free PMC Article
  3. Ciglitazone-a human PPARγ agonist-disrupts dorsoventral patterning in zebrafish. Cheng V, et al. PeerJ, 2019. PMID 31741801, Free PMC Article
  4. Melatonin and peripheral circuitries: insights on appetite and metabolism in Danio rerio. Piccinetti CC, et al. Zebrafish, 2013 Sep. PMID 23682835, Free PMC Article
  5. Temporal and spatial patterns of gene expression in skeletal muscles in response to swim training in adult zebrafish (Danio rerio). LeMoine CM, et al. J Comp Physiol B, 2010 Jan. PMID 19693513

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibition of PPARdelta reduced cardiomyocyte proliferation during zebrafish heart regeneration.
    Title: Live cell screening platform identifies PPARδ as a regulator of cardiomyocyte proliferation and cardiac repair.
  2. This study reveals a unique regulatory mechanism, the Rgs2-Ppard-Sox10 signaling cascade, and defines a key molecular regulator, Rgs2, in neural crest development.
    Title: Regulator of G protein signaling 2 (Rgs2) regulates neural crest development through Pparδ-Sox10 cascade.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hormone-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cholesterol storage IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
peroxisome proliferator-activated receptor delta b; peroxisome proliferator-activated receptor delta
Names
FAAR
NR1C2-B
NUC1
PPAR[b](II)
nr1c2b
peroxisome proliferator activated receptor beta 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131468.2 → NP_571543.1  peroxisome proliferator-activated receptor delta b

    See identical proteins and their annotated locations for NP_571543.1

    Status: VALIDATED

    Source sequence(s)
    AI878499, BC162172, BM811918, EH576387
    UniProtKB/TrEMBL
    A9C4A5, F6P085
    Related
    ENSDARP00000110137.1, ENSDART00000128783.3
    Conserved Domains (2) summary
    cd06932
    Location:250 → 516
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:151 → 234
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    23703380..23725047
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009303928.3 → XP_009302203.1  peroxisome proliferator-activated receptor delta isoform X1

    See identical proteins and their annotated locations for XP_009302203.1

    UniProtKB/TrEMBL
    A9C4A5, F6P085
    Related
    ENSDARP00000120571.1, ENSDART00000132584.3
    Conserved Domains (2) summary
    cd06932
    Location:250 → 516
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:151 → 234
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

  2. XM_009303927.3 → XP_009302202.1  peroxisome proliferator-activated receptor delta isoform X1

    See identical proteins and their annotated locations for XP_009302202.1

    UniProtKB/TrEMBL
    A9C4A5, F6P085
    Conserved Domains (2) summary
    cd06932
    Location:250 → 516
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:151 → 234
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

  3. XM_005166987.4 → XP_005167044.1  peroxisome proliferator-activated receptor delta isoform X1

    See identical proteins and their annotated locations for XP_005167044.1

    UniProtKB/TrEMBL
    A9C4A5, F6P085
    Conserved Domains (2) summary
    cd06932
    Location:250 → 516
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:151 → 234
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
Nucleotide Protein Strain
Heading Accession and Version

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