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Socs6 suppressor of cytokine signaling 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 307200, updated on 4-Apr-2024

Summary

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Official Symbol
Socs6provided by RGD
Official Full Name
suppressor of cytokine signaling 6provided by RGD
Primary source
RGD:1304632
See related
Ensembl:ENSRNOG00000038212 AllianceGenome:RGD:1304632
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity. Predicted to be involved in phosphatidylinositol phosphate biosynthetic process. Predicted to act upstream of or within negative regulation of T cell activation; proteasomal protein catabolic process; and regulation of growth. Predicted to be located in immunological synapse. Predicted to be part of phosphatidylinositol 3-kinase complex. Orthologous to human SOCS6 (suppressor of cytokine signaling 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 164.4), Muscle (RPKM 128.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
18q13
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (84386587..84413927, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (82111866..82139193, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (85962729..85981125, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103694260 Neighboring gene uncharacterized LOC102546314 Neighboring gene replication protein A1, pseudogene 1 Neighboring gene ATP synthase peripheral stalk-membrane subunit b, pseudogene 2 Neighboring gene chimerin 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. BC-Box Motif in SOCS6 Induces Differentiation of Epidermal Stem Cells into GABAnergic Neurons. Yoshizumi T, et al. Int J Mol Sci, 2020 Jul 13. PMID 32668737, Free PMC Article
  2. Suppressor of cytokine signalling-6 promotes neurite outgrowth via JAK2/STAT5-mediated signalling pathway, involving negative feedback inhibition. Gupta S, et al. PLoS One, 2011. PMID 22125600, Free PMC Article
  3. miR-155-5p Implicates in the Pathogenesis of Renal Fibrosis via Targeting SOCS1 and SOCS6. Zhang W, et al. Oxid Med Cell Longev, 2020. PMID 32587662, Free PMC Article
  4. SOCS-6 negatively regulates T cell activation through targeting p56lck to proteasomal degradation. Choi YB, et al. J Biol Chem, 2010 Mar 5. PMID 20007709, Free PMC Article
  5. Suppressors of cytokine signaling-1 and -6 associate with and inhibit the insulin receptor. A potential mechanism for cytokine-mediated insulin resistance. Mooney RA, et al. J Biol Chem, 2001 Jul 13. PMID 11342531

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. BC-Box Motif in SOCS6 Induces Differentiation of Epidermal Stem Cells into GABAnergic Neurons.
    Title: BC-Box Motif in SOCS6 Induces Differentiation of Epidermal Stem Cells into GABAnergic Neurons.
  2. miR-155-5p Implicates in the Pathogenesis of Renal Fibrosis via Targeting SOCS1 and SOCS6.
    Title: miR-155-5p Implicates in the Pathogenesis of Renal Fibrosis via Targeting SOCS1 and SOCS6.
  3. Findings define a molecular mechanism for Jak2/Stat5 mediated Suppressor of cytokine signalling-6 (SOCS6) signalling.
    Title: Suppressor of cytokine signalling-6 promotes neurite outgrowth via JAK2/STAT5-mediated signalling pathway, involving negative feedback inhibition.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
NOT acts_upstream_of_or_within intracellular glucose homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of T cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteasomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of growth ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in immunological synapse ISO
Inferred from Sequence Orthology
more info
  
part_of phosphatidylinositol 3-kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
suppressor of cytokine signaling 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271149.3 → NP_001258078.1  suppressor of cytokine signaling 6

    See identical proteins and their annotated locations for NP_001258078.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    D3ZS84
    Related
    ENSRNOP00000054982.4, ENSRNOT00000058179.5
    Conserved Domains (2) summary
    cd10387
    Location:385 → 484
    SH2_SOCS6; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03740
    Location:507 → 547
    SOCS_SOCS6; SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    84386587..84413927 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039096760.2 → XP_038952688.1  suppressor of cytokine signaling 6 isoform X1

    UniProtKB/TrEMBL
    D3ZS84
    Related
    ENSRNOP00000091475.1
    Conserved Domains (2) summary
    cd10387
    Location:385 → 484
    SH2_SOCS6; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03740
    Location:507 → 547
    SOCS_SOCS6; SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...

  2. XM_039096761.2 → XP_038952689.1  suppressor of cytokine signaling 6 isoform X1

    UniProtKB/TrEMBL
    D3ZS84
    Related
    ENSRNOP00000089791.1
    Conserved Domains (2) summary
    cd10387
    Location:385 → 484
    SH2_SOCS6; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03740
    Location:507 → 547
    SOCS_SOCS6; SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...

  3. XM_039096764.2 → XP_038952692.1  suppressor of cytokine signaling 6 isoform X1

    UniProtKB/TrEMBL
    D3ZS84
    Conserved Domains (2) summary
    cd10387
    Location:385 → 484
    SH2_SOCS6; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03740
    Location:507 → 547
    SOCS_SOCS6; SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...

  4. XM_039096763.2 → XP_038952691.1  suppressor of cytokine signaling 6 isoform X1

    UniProtKB/TrEMBL
    D3ZS84
    Conserved Domains (2) summary
    cd10387
    Location:385 → 484
    SH2_SOCS6; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03740
    Location:507 → 547
    SOCS_SOCS6; SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...

  5. XM_039096762.2 → XP_038952690.1  suppressor of cytokine signaling 6 isoform X1

    UniProtKB/TrEMBL
    D3ZS84
    Conserved Domains (2) summary
    cd10387
    Location:385 → 484
    SH2_SOCS6; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03740
    Location:507 → 547
    SOCS_SOCS6; SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...
Nucleotide Protein Strain
Heading Accession and Version

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