Akr1c1 aldo-keto reductase family 1, member C1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Akr1c1provided by RGD
Official Full Name: aldo-keto reductase family 1, member C1provided by RGD
Primary source: RGD:1306847
See related: Ensembl:ENSRNOG00000038331 AllianceGenome:RGD:1306847
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Akr1c6; Hsd17b5
Summary: Enables 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity and testosterone 17-beta-dehydrogenase (NADP+) activity. Involved in response to estrogen and response to xenobiotic stimulus. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8; B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; and leukemia. Orthologous to several human genes including AKR1C4 (aldo-keto reductase family 1 member C4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 1618.5) See more
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Genomic context

Location:: 17q12.2

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (70720397..70747285, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (65810474..65837385, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (69441253..69460334, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables aldose reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables aldose reductase (NADPH) activity	ISO Inferred from Sequence Orthology more info
enables androsterone dehydrogenase (B-specific) activity	ISO Inferred from Sequence Orthology more info
enables androsterone dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables bile acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables bile acid binding	ISO Inferred from Sequence Orthology more info
enables carboxylic acid binding	ISO Inferred from Sequence Orthology more info
enables estradiol 17-beta-dehydrogenase [NAD(P)] activity	ISO Inferred from Sequence Orthology more info
enables ketosteroid monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ketosteroid monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	ISO Inferred from Sequence Orthology more info
enables phenanthrene 9,10-monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables testosterone 17-beta-dehydrogenase (NADP+) activity	IDA Inferred from Direct Assay more info	PubMed
enables trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in bile acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cellular response to jasmonic acid stimulus	ISO Inferred from Sequence Orthology more info
involved_in daunorubicin metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in daunorubicin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in digestion	ISO Inferred from Sequence Orthology more info
involved_in doxorubicin metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in doxorubicin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in progesterone metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in progesterone metabolic process	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to estrogen	IDA Inferred from Direct Assay more info	PubMed
involved_in response to organophosphorus	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in retinal metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within steroid metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: aldo-keto reductase family 1, member C1

Names: 20-alpha (3-alpha)-hydroxysteroid dehydrogenase); aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase); aldo-keto reductase family 1, member C6; type 5 17beta-hydroxysteroid dehydrogenase

NP_001028869.1

EC 1.1.1.149

XP_006254250.1

EC 1.1.1.149

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033697.1 → NP_001028869.1 aldo-keto reductase family 1, member C1

See identical proteins and their annotated locations for NP_001028869.1

Status: PROVISIONAL

Source sequence(s)

BC104716

UniProtKB/TrEMBL

Q3MHS3, Q5I0L1

Related

ENSRNOP00000055169.2, ENSRNOT00000058367.4

Conserved Domains (2) summary

COG0656
Location:5 → 305

ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]

COG0667
Location:16 → 297

Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

70720397..70747285 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006254188.5 → XP_006254250.1 aldo-keto reductase family 1, member C1 isoform X1

UniProtKB/TrEMBL

A0A8I6AV33

Related

ENSRNOP00000097530.1

Conserved Domains (2) summary

COG0656
Location:5 → 283

ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]

COG0667
Location:16 → 282

Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]