dlx2a distal-less homeobox 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dlx2aprovided by ZNC
Official Full Name: distal-less homeobox 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-212
See related: Ensembl:ENSDARG00000079964 AllianceGenome:ZFIN:ZDB-GENE-980526-212
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: dlx2; dlx-2; zgc:110518
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including neural crest cell development; pharyngeal system development; and skeletal system development. Predicted to be located in nucleus. Is expressed in several structures, including brain; cranial cartilage; neural crest; pectoral fin bud; and pharyngeal arch. Orthologous to human DLX2 (distal-less homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (3397407..3400729, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (3425878..3429200, complement)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that dlx1a/2a and dlx5a/6a expressing progenitors give rise, for the most part, to small populations of cells which constitute only a small proportion of GABAergic cells in the adult brain tissue.
Title: Lineage tracing of dlx1a/2a and dlx5a/6a expressing cells in the developing zebrafish brain.
dlx1a/2a act downstream of ascl1a but upstream of dlx5a/dlx6a and gad1b to activate GABAergic specification
Title: The ascl1a and dlx genes have a regulatory role in the development of GABAergic interneurons in the zebrafish diencephalon.
This study demonistrated that dlex2 expresssion aroud striatal and pallidal territories.
Title: Contributions of developmental studies in the dogfish Scyliorhinus canicula to the brain anatomy of elasmobranchs: insights on the basal ganglia.
embryos injected with dlx1a and dlx2a but not dlx1a MOs exhibit reduced and dysmorphic arch cartilage elements.
Title: Zebrafish dlx2a contributes to hindbrain neural crest survival, is necessary for differentiation of sensory ganglia and functions with dlx1a in maturation of the arch cartilage elements.

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General gene information

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Markers

fc28e03.x1 (e-PCR)
- UniSTS:193413

dlx2 (e-PCR)
- UniSTS:238236

dlx2 (e-PCR)
- UniSTS:204717

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cartilage development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in chordate embryonic development	IEA Inferred from Electronic Annotation more info
involved_in embryo development	IBA Inferred from Biological aspect of Ancestor more info
involved_in embryonic morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic viscerocranium morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic viscerocranium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neural crest cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within peripheral nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pharyngeal system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ribosome biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: homeobox protein Dlx2a

Names: distal-less homeobox gene 2a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131311.2 → NP_571386.2 homeobox protein Dlx2a

Status: VALIDATED

Source sequence(s)

CU469503, DT059718

UniProtKB/Swiss-Prot

P50574

UniProtKB/TrEMBL

A0A8N7UZI8, F6NKE2

Related

ENSDARP00000103004.2, ENSDART00000111386.4

Conserved Domains (2) summary

pfam00046
Location:130 → 183

Homeobox; Homeobox domain

pfam12413
Location:32 → 107

DLL_N; Homeobox protein distal-less-like N terminal