U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Lamb3 laminin subunit beta 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305078, updated on 13-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Lamb3provided by RGD
Official Full Name
laminin subunit beta 3provided by RGD
Primary source
RGD:1562668
See related
Ensembl:ENSRNOG00000006025 AllianceGenome:RGD:1562668
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be an extracellular matrix structural constituent. Predicted to be involved in several processes, including basement membrane assembly; endodermal cell differentiation; and substrate adhesion-dependent cell spreading. Predicted to act upstream of or within brown fat cell differentiation. Predicted to be located in basement membrane. Predicted to be part of laminin-5 complex. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 1A; junctional epidermolysis bullosa; junctional epidermolysis bullosa Herlitz type; junctional epidermolysis bullosa non-Herlitz type; and lung small cell carcinoma. Orthologous to human LAMB3 (laminin subunit beta 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 195.6), Thymus (RPKM 45.7) and 5 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
13q27
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (107362514..107404081)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (104833810..104875405)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (112031614..112073187)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene hydroxysteroid 11-beta dehydrogenase 1 Neighboring gene G0/G1switch 2 Neighboring gene calcium/calmodulin-dependent protein kinase IG Neighboring gene microRNA 205

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A homozygous nonsense mutation in the beta 3 chain gene of laminin 5 (LAMB3) in Herlitz junctional epidermolysis bullosa. Pulkkinen L, et al. Genomics, 1994 Nov 15. PMID 7698759
  2. Epigenetic inactivation of laminin-5-encoding genes in lung cancers. Sathyanarayana UG, et al. Clin Cancer Res, 2003 Jul. PMID 12855645
  3. Laminin alpha 5, a major transcript of normal and malignant rat liver epithelial cells, is differentially expressed in developing and adult liver. Seebacher T, et al. Exp Cell Res, 1997 Nov 25. PMID 9417868
  4. Epitope mapping of function-blocking monoclonal antibody CM6 suggests a "weak" integrin binding site on the laminin-332 LG2 domain. Yamashita H, et al. J Cell Physiol, 2010 Jun. PMID 20301201, Free PMC Article
  5. Differential expression of the LAMB3 and LAMC2 genes between small cell and non-small cell lung carcinomas. Manda R, et al. Biochem Biophys Res Commun, 2000 Aug 28. PMID 10964684

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Binding sites for alpha3beta1 and alpha6beta4 are closely spaced in the Ln-332 LG domains where they regulate alternative cell functions, namely adhesion/migration or hemidesmosome anchoring.
    Title: Epitope mapping of function-blocking monoclonal antibody CM6 suggests a "weak" integrin binding site on the laminin-332 LG2 domain.
  2. In bladder carcinoma laminin-332 can suppress the number of invadopodia that form by interacting with a3b1 integrin and altering the cellular balance of FAK and Src kinase activity.
    Title: Laminin-332-beta1 integrin interactions negatively regulate invadopodia.
  3. a complex of laminin alpha 3, beta3 and gamma3 chains serves as the ligand for alpha 6beta1-integrin at the apical ectoplasmic specialization in adult rat testes
    Title: Laminin alpha 3 forms a complex with beta3 and gamma3 chains that serves as the ligand for alpha 6beta1-integrin at the apical ectoplasmic specialization in adult rat testes.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in basement membrane assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within brown fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endodermal cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in substrate adhesion-dependent cell spreading IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tissue development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in basement membrane ISO
Inferred from Sequence Orthology
more info
  
part_of laminin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of laminin-5 complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
laminin subunit beta-3
Names
laminin chain
laminin, beta 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100841.1 → NP_001094311.1  laminin subunit beta-3 precursor

    See identical proteins and their annotated locations for NP_001094311.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A6JH29, F1LPI5
    Related
    ENSRNOP00000008440.4, ENSRNOT00000008440.7
    Conserved Domains (5) summary
    smart00180
    Location:535 → 572
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    cd00055
    Location:431 → 480
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00053
    Location:380 → 429
    Laminin_EGF; Laminin EGF domain
    cl02488
    Location:909 → 1092
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl02806
    Location:21 → 249
    Laminin_N; Laminin N-terminal (Domain VI)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    107362514..107404081
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008769856.4 → XP_008768078.1  laminin subunit beta-3 isoform X1

    See identical proteins and their annotated locations for XP_008768078.1

    UniProtKB/TrEMBL
    A6JH29, F1LPI5
    Conserved Domains (5) summary
    smart00180
    Location:535 → 572
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    cd00055
    Location:431 → 480
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00053
    Location:380 → 429
    Laminin_EGF; Laminin EGF domain
    cl02488
    Location:909 → 1092
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl02806
    Location:21 → 249
    Laminin_N; Laminin N-terminal (Domain VI)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous