Dcaf7 DDB1 and CUL4 associated factor 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dcaf7provided by RGD
Official Full Name: DDB1 and CUL4 associated factor 7provided by RGD
Primary source: RGD:1305140
See related: Ensembl:ENSRNOG00000042245 AllianceGenome:RGD:1305140
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Wdr68; RGD1305140
Summary: Predicted to be located in cytosol; nuclear body; and nuclear matrix. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Predicted to be active in nucleus. Orthologous to human DCAF7 (DDB1 and CUL4 associated factor 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 146.1), Brain (RPKM 144.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.1

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (91473900..91496080)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (90974095..90996275)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (94231585..94254046)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Component	Evidence Code	Pubs
part_of Cul4-RING E3 ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nuclear matrix	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: DDB1- and CUL4-associated factor 7

Names: WD repeat domain 68

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107057.3 → NP_001100527.1 DDB1- and CUL4-associated factor 7

See identical proteins and their annotated locations for NP_001100527.1

Status: VALIDATED

Source sequence(s)

BC167045, JAXUCZ010000010

UniProtKB/TrEMBL

A0A8I6AKC6, A6HJZ8, B2RZ68, F7FJY8

Related

ENSRNOP00000061467.2, ENSRNOT00000063858.3

Conserved Domains (2) summary

sd00039
Location:71 → 116

7WD40; WD40 repeat [structural motif]

cl29593
Location:19 → 295

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...